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Publication Type J
Authors Chen, L., W. L. Wang, T. F. Song, X. Xie, X. W. Ye, Y. Liang, H. C. Huang, S. L. Yan, X. Y. Lian and Z. Z. Zhang
Title Anti-colorectal cancer effects of tripolinolate A from Tripolium vulgare
Source Chinese Journal of Natural Medicines
Author Keywords Tripolinolate A Colorectal cancer cells Apoptosis Cell cycle Anti-colorectal tumor effects acid 3,4-dihydroxyphenethyl ester cucumber holothuria-moebii sulfated saponins phenethyl ester anticancer plasma agents
Abstract Tripolinolate A (TLA) is recently identified as a new compound from a halophyte plant Tripolium vulgare and has been shown to have significant in vitro activity against the proliferation of colorectal cancer and glioma cells. This study was designed to further investigate the effects of TLA on the proliferation of human normal cells, and the apoptosis and cell cycle in colorectal cancer cells, and the growth of tumors in the colorectal cancer-bearing animals. The data obtained from this study demonstrated that: 1) TLA had much less cytotoxicity in the human normal cells than the colorectal cancer cells; 2) TLA remarkably induced apoptosis in the human colorectal cancer cells and blocked cell cycle at G(2)/M phase, and 3) TLA had significant anti-colorectal cancer activity in the tumor-bearing animals.
Author Address [Chen, Lu; Wang, Wen-Ling; Song, Teng-Fei; Ye, Xue-Wei; Liang, Ying; Huang, Hao-Cai; Yan, Shi-Lun; Zhang, Zhi-Zhen] Zhejiang Univ, Ocean Coll, Zhoushan Campus, Zhoushan 316021, Peoples R China. [Xie, Xin; Lian, Xiao-Yuan] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China. Zhang, ZZ (reprint author), Zhejiang Univ, Ocean Coll, Zhoushan Campus, Zhoushan 316021, Peoples R China.; Lian, XY (reprint author), Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China. xylian@zju.edu.cn; zzhang88@zju.edu.cn
ISSN 2095-6975
ISBN 2095-6975
29-Character Source Abbreviation Chin. J. Nat. Med.
Publication Date Aug
Year Published 2017
Volume 15
Issue 8
Beginning Page 576-583
Digital Object Identifier (DOI) 10.3724/sp.j.1009.2017.00576
Unique Article Identifier WOS:000412794100002

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