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Publication Type J
Authors Kim, HJ; Jeong, HJ; Hong, JW; Ju, ES; Kong, CS; Seo, YW
Author Full Name Kim, Hojun; Jeong, Huijeong; Hong, Joo Wan; Ju, Eunshin; Kong, Chang-Suk; Seo, Youngwan
Title Evaluation of Flavonoids from Zostera asiatica as Antioxidants and Nitric Oxide Inhibitors
Source BIOTECHNOLOGY AND BIOPROCESS ENGINEERING
Language English
Document Type Article
Author Keywords antioxidant; flavonoid; luteolin 3 '-sulfate; scavenging effect; Zostera asiatica
Keywords Plus OXIDATIVE STRESS; PHENOLIC-ACIDS; MARINA L; EELGRASS; DISEASE; LEAVES; EXTRACT
Abstract Zostera asiatica is one of the five members of the genus Zostera that can be found in Korea. Studies have reported the phytochemical properties and bioactivities of Zostera species. Current study focused on the antioxidant effects of Z. asiatica as a part of ongoing research for bioactive substances from marine resources. Results indicated that a crude extract of Z. asiatica not only scavenged on peroxynitrite in vitro and on intracellular reactive oxygen species (ROS) but also inhibited production of nitric oxide (NO). The crude extract was subjected to solvent fractionation for bioactivity-based separation using aforementioned three bioassay systems. From the active n-butanol fraction, two flavonoids were isolated and characterized as luteolin (1) and luteolin-3'-sulfate (2). Both flavonoids showed significant antioxidant effects. In conclusion, Z. asiatica was demonstrated to possess antioxidant effect partly attributed to isolated flavonoids, the first such effect reported from Z. asiatica, to the best of our knowledge.
Author Address [Kim, Hojun; Hong, Joo Wan; Ju, Eunshin; Seo, Youngwan] Korea Maritime & Ocean Univ, Coll Ocean Sci & Technol, Div Marine Biosci, Busan 49112, South Korea; [Jeong, Huijeong; Seo, Youngwan] Korea Maritime & Ocean Univ, Ocean Sci & Technol Sch, Dept Convergence Study Ocean Sci & Technol, Busan 49112, South Korea; [Kong, Chang-Suk] Silla Univ, Dept Food & Nutr, Coll Med & Life Sci, Busan 46958, South Korea; [Kong, Chang-Suk] Silla Univ, Marine Biotechnol Ctr Pharmaceut & Foods, Busan 46958, South Korea
Reprint Address Seo, YW (reprint author), Korea Maritime & Ocean Univ, Coll Ocean Sci & Technol, Div Marine Biosci, Busan 49112, South Korea.
E-mail Address ywseo@kmou.ac.kr
Funding Agency and Grant Number Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [2012R1A1A2002851]
Funding Text Mass spectral data were kindly provided by Korea Basic Science Institute. This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (No. 2012R1A1A2002851).
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Cited Reference Count 30
Publisher KOREAN SOC BIOTECHNOLOGY & BIOENGINEERING
Publisher City SEOUL
Publisher Address KOREAN SCIENCE TECHNOLOGY CENTER, #704 YEOGSAM-DONG, KANGNAM-KU, SEOUL 135-703, SOUTH KOREA
ISSN 1226-8372
29-Character Source Abbreviation BIOTECHNOL BIOPROC E
ISO Source Abbreviation Biotechnol. Bioprocess Eng.
Publication Date NOV
Year Published 2016
Volume 21
Issue 6
Beginning Page 823
Ending Page 829
Digital Object Identifier (DOI) 10.1007/s12257-016-0567-9
Page Count 7
Web of Science Category Biotechnology & Applied Microbiology
Subject Category Biotechnology & Applied Microbiology
Document Delivery Number EI2WJ
Unique Article Identifier WOS:000392348800016
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