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Publication Type J
Authors Chen, J., J. H. Teng, L. Ma, H. Y. Tong, B. R. Ren, L. S. Wang and W. L. Li
Title Flavonoids Isolated From the Flowers of Limonium bicolor and their In vitro Antitumor Evaluation
Source Pharmacognosy Magazine
Author Keywords Limonium bicolor flavonoids antitumor activity triterpenoids
Abstract Background: Limonium bicolor, a halophytic species, can grow in saline or saline-alkali soil, is well known as a traditional Chinese medicine. Recently it attracted much attention for its treatment for cancer. Objective: The present study was performed to evaluate this species from the phytochemical standpoint and the possible relationship between the antitumor activity and its natural products. Materials and methods: The chemical constituents from the flowers of L. bicolor were investigated through bioassay-guided fractionation and isolation. All the individual compounds were characterized by spectroscopic analysis and their potential antitumor activity was tested against three different human tumor cell lines by MTT assays. Results: The EtOAc extract was proven as the most potent fraction and further fractionation led to the isolation of 15 natural flavonoids, which were characterized as luteolin (1), acacetin (2), quercetin (3), isorhamnetin (4), kaempferol (5), eriodictyol (6), kaempferol-3-O-alpha-L-rhamnoside (7), kaempferol-3-O-beta-D-glucoside (8), quercetin-3-O-a-L-rhamnoside (9), quercetin-3-O-alpha-D-glucoside (10), quercetin-3-O-beta-D-galactoside (11), myricetin-3-O-alpha-L-rhamnoside (12), kaempferol-3-O-(6"-O-galloyl)-beta-Dglucoside (13), hesperidin (14) and rutin (15). The biotesting results demonstrated that both compounds 1 and 3 showed good cytotoxicity against human colon cancer cells (LOVO). Compound 5 exhibited relative greater growth inhibition against both human breast cancer cells (MCF-7) and osteosarcoma cell lines (U2-OS) at the concentration of 100 mu g/ mL. Conclusion: On the basis of these findings, the flavonoids were deduced to be potentially responsible for the antitumor activity of L. bicolor. The preliminary structure-activity relationship analysis suggests that the 3-O-glycosylation moiety in natural flavonoids was not essential for the antiproliferative activity on LOVO and U2-OS cells.
Author Address [Chen, Jian; Teng, Jiehui; Ma, Li; Tong, Haiying; Ren, Bingru; Wang, Linshan; Li, Weilin] Jiangsu Prov & Chinese Acad Sci, Inst Bot, Nanjing, Jiangsu, Peoples R China. [Chen, Jian; Tong, Haiying; Ren, Bingru] Jiangsu Prov Platform Conservat & Utilizat Agr Ge, Nanjing, Jiangsu, Peoples R China. Li, WL (reprint author), Jiangsu Prov & Chinese Acad Sci, Inst Bot, Nanjing, Jiangsu, Peoples R China. lwlcnbg@mail.cnbg.net
ISSN 0973-1296
ISBN 0973-1296
29-Character Source Abbreviation Pharmacogn. Mag.
Publication Date Apr-Jun
Year Published 2017
Volume 13
Issue 50
Beginning Page 222-225
Digital Object Identifier (DOI) 10.4103/0973-1296.204566
Unique Article Identifier WOS:000406871700004

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