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Publication Type J
Authors Ragasa, CY; Espineli, DL; Shen, CC
Author Full Name Ragasa, Consolacion Y.; Espineli, Dinah L.; Shen, Chien-Chang
Title A new triterpene from Barringtonia asiatica
Source NATURAL PRODUCT RESEARCH
Language English
Document Type Article
Author Keywords Barringtonia asiatica; Lecythidaceae; (3 beta,11 alpha)-11-hydroxyolean-12-en-3-yl palmitate; germanicol; 22-O-tigloylcamelliagenin A; verimol k
Keywords Plus SAPONINS; SEEDS
Abstract The freeze-dried bark of Barringtonia asiatica afforded a new triterpene: (3 beta,11 alpha)-11-hydroxyolean-12-en-3-yl palmitate (1). The bark also yielded mixtures of (3 beta)-olean-12-en-3-yl palmitate (2a), (3 beta)-urs-12-en-3-yl palmitate (2b) and (3 beta)-olean-18-en-3-yl palmitate (2c) in a 2 : 1 : 4 ratio; beta-amyrin (3a), alpha-amyrin (3b) and germanicol (3c) in a 3 : 1 : 4 ratio; 22-O-tigloylcamelliagenin A (4a) and betulinic acid (4b) in a 2 : 1 ratio; olean-12-en-3 beta,16 beta,22 alpha-triol (5), beta-sitosterol, spinasterol, squalene and trilinolein. The roots yielded 2a-c and 3a-c as well as trilinolein, spinasterol and squalene, while the flowers afforded verimol k (6), linoleic acid, spinasterol, squalene, phytyl fatty acid ester and trilinolein. Compounds 1-4 and 6 were tested for antimicrobial property against seven microorganisms. All compounds tested exhibited slight activity against Candida albicans and were found inactive against Escherichia coli, Bacillus subtilis, Trichophyton mentagrophytes and Aspergillus niger. Except for the mixture of 4a and 4b that proved to be inactive, all the compounds were slightly active against the bacterium Staphylococcus aureus, while 3a-c were slightly active against Pseudomonas aeruginosa.
Author Address [Ragasa, Consolacion Y.; Espineli, Dinah L.] De La Salle Univ, Dept Chem, Manila 1004, Philippines; [Ragasa, Consolacion Y.; Espineli, Dinah L.] De La Salle Univ, Ctr Nat Sci & Ecol Res, Manila 1004, Philippines; [Shen, Chien-Chang] Natl Res Inst Chinese Med, Taipei 112, Taiwan
Reprint Address Ragasa, CY (reprint author), De La Salle Univ, Dept Chem, 2401 Taft Ave, Manila 1004, Philippines.
E-mail Address consolacion.ragasa@dlsu.edu.ph
ORCID Number Ragasa, Consolacion/0000-0002-6687-6940
Funding Agency and Grant Number Science Foundation of De La Salle University
Funding Text A research grant from the Science Foundation of De La Salle University is gratefully acknowledged. The antimicrobial tests were conducted at the University of the Philippines - Natural Sciences Research Institute.
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Cited Reference Count 19
Times Cited 5
Total Times Cited Count (WoS, BCI, and CSCD) 6
Publisher TAYLOR & FRANCIS LTD
Publisher City ABINGDON
Publisher Address 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
ISSN 1478-6419
29-Character Source Abbreviation NAT PROD RES
ISO Source Abbreviation Nat. Prod. Res.
Year Published 2012
Volume 26
Issue 20
Beginning Page 1869
Ending Page 1875
Digital Object Identifier (DOI) 10.1080/14786419.2011.619187
Page Count 7
Web of Science Category Chemistry, Applied; Chemistry, Medicinal
Subject Category Chemistry; Pharmacology & Pharmacy
Document Delivery Number 010VS
Unique Article Identifier WOS:000309123200003
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