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Publication Type J
Authors Ben Hmidene, A., M. Hanaki, K. Murakami, K. Irie, H. Isoda and H. Shigemori
Title Inhibitory Activities of Antioxidant Flavonoids from Tamarix gallica on Amyloid Aggregation Related to Alzheimer's and Type 2 Diabetes Diseases
Source Biological & Pharmaceutical Bulletin
Author Keywords amyloid aggregation glucuronosylated flavonoid Tamarix gallica Alzheimer's disease type 2 diabetes beta aggregation protein constituents
Abstract The prevention of amyloid aggregation is promising for the treatment of age-related diseases such as Alzheimer's (AD) and type 2 diabetes (T2D). Ten antioxidant flavonoids isolated from the medicinal halophyte Tamarix gallica were tested for their amyloid aggregation inhibition potential. Glucuronosylated flavonoids show relatively strong inhibitory activity of Amyloid beta (A beta) and human islet amyloid polypeptide (hIAPP) aggregation compared to their aglycone analogs. Structure-activity relationship of the flavonoids suggests that the catechol moiety is important for amyloid aggregation inhibition, while the methylation of the carboxyl group in the glucuronide moiety and of the hydroxyl group in the aglycone flavonoids decreased it.
Author Address [Ben Hmidene, Asma] Univ Tsukuba, Grad Sch Life & Environm Sci, Tsukuba, Ibaraki 3058572, Japan. [Hanaki, Mizuho; Murakami, Kazuma; Irie, Kazuhiro] Kyoto Univ, Grad Sch Biostudies, Sakyo Ku, Kyoto 6068502, Japan. [Isoda, Hiroko] Univ Tsukuba, Alliance Res North Africa ARENA, Tsukuba, Ibaraki 3058572, Japan. [Isoda, Hiroko; Shigemori, Hideyuki] Univ Tsukuba, Fac Life & Environm Sci, Tsukuba, Ibaraki 3058572, Japan. Shigemori, H (reprint author), Univ Tsukuba, Fac Life & Environm Sci, Tsukuba, Ibaraki 3058572, Japan. shigemori.hideyuk.fn@u.tsukuba.ac.jp
ISSN 0918-6158
ISBN 0918-6158
29-Character Source Abbreviation Biol. Pharm. Bull.
Publication Date Feb
Year Published 2017
Volume 40
Issue 2
Beginning Page 238-241
Unique Article Identifier WOS:000393086200018

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