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Publication Type J
Authors Rajamurugan, R; Suyavaran, A; Selvaganabathy, N; Ramamurthy, CH; Reddy, GP; Sujatha, V; Thirunavukkarasu, C
Author Full Name Rajamurugan, R.; Suyavaran, A.; Selvaganabathy, N.; Ramamurthy, C. H.; Reddy, G. Pramodh; Sujatha, V.; Thirunavukkarasu, C.
Title Brassica nigra plays a remedy role in hepatic and renal damage
Source PHARMACEUTICAL BIOLOGY
Language English
Document Type Article
Author Keywords Antioxidant; D-galactosamine; lipid peroxidation; oxidative stress; phytochemistry
Keywords Plus SESQUITERPENE LACTONES; CATHEPSIN-D; LIVER; RATS; GALACTOSAMINE; ANTIOXIDANT; FAILURE; ASSAY
Abstract Context: Black mustard [Brassica nigra (L.) Koch] of the Brassicaceae (Cruciferae) family is commonly used as a spice and a cheap source of antimicrobial agents for bacterial infections. Objectives: The present investigation was to demonstrate the protective effect of the methanol extract of B. nigra leaves against D-galactosamine (D-GalN)-induced hepatic and nephrotoxicity in Wistar rats. Methods: Activity of the methanol extract of B. nigra at doses of 200 and 400 mg/kg b.wt. against D-GalN (500 mg/kg b.wt.) induced toxicity, with silymarin used as the standard. Histological damage, activities of serum marker enzyme, hematological changes, metabolites such as bilirubin, urea, uric acid, and creatinine levels, tissue thiobarbutric acid reactive substance, enzymic and non-enzymic antioxidants and inflammatory marker enzymes such as myeloperoxidase, cathepsin D, and acid phosphatase were assessed. Results: The D-GalN-induced toxicity was evident from a significant increase (p < 0.001) in the serum and tissue inflammatory markers in toxic rats, when compared with the control (saline alone treated animals). The B. nigra pretreated groups (200 and 400 mg/kg b.wt.) showed significant (p < 0.001) reduction in the D-GalN-induced toxicity as obvious from biochemical parameters. Histopathological observations confirm the protective effect of B. nigra leaf extract by reduction in hepatic and renal tissue damage. Experimentals extract showed a similar effect as the standard. Conclusions: The crude methanol extract of B. nigra leaf lacks inherent toxicity and exhibits hepatic and nephroprotective effects against D-GalN-induced toxicity in Wistar rats.
Author Address [Suyavaran, A.; Selvaganabathy, N.; Ramamurthy, C. H.; Thirunavukkarasu, C.] Pondicherry Univ, Dept Biochem & Mol Biol, Pondicherry, India; [Rajamurugan, R.] MGR Coll, PG & Res Dept Biochem, Hosur, India; [Rajamurugan, R.; Thirunavukkarasu, C.] Periyar Univ, Dept Biochem, Salem, India; [Reddy, G. Pramodh] Siddah Cent Res Inst, Madras, Tamil Nadu, India; [Sujatha, V.] Periyar Univ, Dept Chem, Salem, India
Reprint Address Thirunavukkarasu, C (reprint author), Pondicherry Univ, Dept Biochem & Mol Biol, Pondicherry, India.
E-mail Address tchinnasamy@hotmail.com
ORCID Number Thirunavukkarasu, Chinnasamy/0000-0002-2339-997X
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Cited Reference Count 41
Times Cited 3
Total Times Cited Count (WoS, BCI, and CSCD) 3
Publisher INFORMA HEALTHCARE
Publisher City LONDON
Publisher Address TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
ISSN 1388-0209
29-Character Source Abbreviation PHARM BIOL
ISO Source Abbreviation Pharm. Biol.
Publication Date DEC
Year Published 2012
Volume 50
Issue 12
Beginning Page 1488
Ending Page 1497
Digital Object Identifier (DOI) 10.3109/13880209.2012.685129
Page Count 10
Web of Science Category Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
Subject Category Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
Document Delivery Number 041RH
Unique Article Identifier WOS:000311418400003
Plants associated with this reference

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