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Publication Type J
Authors Lellau, T. F. and G. Liebezeit
Title Cytotoxic and antitumor activities of ethanolic extracts of salt marsh plants from the Lower Saxonian Wadden Sea, Southern North Sea
Source Pharmaceutical Biology
Author Keywords salt marsh plants biological screening cytotoxic activity antitumor activity Artemia assay Daphnia assay potato disc assay ANTI-TUMOR ACTIVITY DAPHNIA-MAGNA DISK BIOASSAY CANCER TOXICITY METABOLITES PLASMID CELLS DNA
Abstract Twenty-eight plant species belonging to fifteen families were subjected to a screening for cytotoxic and antitumor activities with three test organisms in six bioassays. Freshly hatched larvae and four week old adults of Artemia salina LEACH are used for the detection of acute toxic activity after 6 h and chronic toxicity after 24h. Adult Daphnia magna STRAUS were used to establish toxic activities of the extract after 48h. Finally the potato disc assay with Agrobacterium tumefaciens was used to detect antitumor compounds. Of the screened plants, Limonium vulgare MILL., Artemisia maritima L. and Salicornia europaea L. showed significant cytotoxic activity against Artemia salina LEACH and Daphnia magna STRAUS. Extracts of these plants also showed anti-neoplastic activities in the potato disk assay. The extracts of Ononis spinosa L., Trifolium fragiferum L. and Trifolium repens L. showed tumor growth inhibiting activities.
Author Address Forschungszentrum Terramare, D-26382 Wilhelmshaven, Germany. Univ Oldenburg, FB Chem, D-2900 Oldenburg, Germany. Liebezeit, G (reprint author), Forschungszentrum Terramare, Schleusenstr 1, D-26382 Wilhelmshaven, Germany.
ISSN 1388-0209
ISBN 1388-0209
Publication Date Jun
Year Published 2003
Volume 41
Issue 4
Beginning Page 293-300
Digital Object Identifier (DOI) 10.1076/phbi.41.4.293.15668
Unique Article Identifier WOS:000184898600017
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