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Publication Type J
Authors Loizzo, M. R., K. Rashed, A. Said, M. Bonesi, F. Menichini and R. Tundis
Title Antiproliferative and antioxidant properties of Alhagi maurorum Boiss (Leguminosae) aerial parts
Source Industrial Crops and Products
Abstract This work is aimed to investigate the antiproliferative and antioxidant activities of Alhagi maurorum, a legume used as natural sweetener. Diethyl ether (DE) and petroleum ether (PE) extracts were analyzed for their chemical composition by GC-MS analysis. Both extract were further investigated for their potential cytotoxicity against a panel of human cancer cell lines by sulforhodamine B (SRB) assay. DE extract, characterized by fatty acids and coumarins as main constituents, showed the strongest activity against C32 melanoma cell line with an IC50 value of 2.7 mu g/ml. For antioxidant investigation different in vitro systems, namely 2,2-diphenylpicrylhydrazyl (DPPH), 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS*(+)), mu-carotene bleaching test, ferric reducing ability power assay (FRAP) and Fe-chelating activity assay were employed. DE extract showed the highest radical scavenging activity against ABTS radical with an IC50 value of 4.7 mu g/ml. This extract was also able to reduce the metal transition ion iron with a FRAP value of 69.6 mu M Fe(II)/g that is comparable to the positive control butylated hydroxytoluene (BHT) (63.2 mu M Fe(II)/g). These biological properties may be of interest from a functional point of view and to propose an alternative use of this edible legume. (C) 2014 Elsevier B.V. All rights reserved.
ISSN 0926-6690
ISBN 0926-6690
Publication Date Feb
Year Published 2014
Volume 53
Beginning Page 289-295
Digital Object Identifier (DOI) 10.1016/j.indcrop.2013.12.049
Unique Article Identifier WOS:000338612500037
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