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Publication Type J
Authors An, R. B., D. H. Sohn, G. S. Jeong and Y. C. Kim
Title In Vitro hepatoprotective compounds from Suaeda glauca
Source Archives of Pharmacal Research
Author Keywords Suaeda glaucahepatoprotectivemethyl 3,5-di-O-caffeoyl quinate3,5-di-O-cafeoyl quinic acidtacrineHep G2 cellschenopodiaceaetacrine-induced cytotoxicityhep g2 cellsconstituentsdisease
Abstract Bioassay-guided fractionation of the MeOH extract of Suaeda glauca yielded four phenolic compounds, methyl 3,5-di-O-caffeoyl quinate (1) and 3,5-di-O-caffeoyl quinic acid (2), isorhamnetin 3-O-beta-D-galactoside (3), and quercetin 3-O-beta-D-galactoside (4). Compounds 1 and 2 were hepatoprotective against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells with the EC(50) values of 72.7 +/- 6.2 and 117.2 +/- 10.5 mu M, respectively. Silybin as a positive control showed an EC(50) value of 82.4 +/- 4.1 mu M.
Author Address [Sohn, Dong-Hwan; Jeong, Gil-Saeng; Kim, Youn-Chul] Wonkwang Univ, Coll Pharm, Iksan 570749, Jeonbuk, South Korea. [An, Ren-Bo] Yanbian Univ, Coll Pharm, Yanji 133000, Jilin, Peoples R China.Kim, YC (reprint author), Wonkwang Univ, Coll Pharm, 344-2 Shinyong Dong, Iksan 570749, Jeonbuk, South Korea.yckim@wku.ac.kr
ISSN 0253-6269
ISBN 0253-6269
Publication Date May
Year Published 2008
Volume 31
Issue 5
Beginning Page 594
Ending Page 597
Digital Object Identifier (DOI) 10.1007/s12272-001-1198-1
Unique Article Identifier WOS:000255874800007
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