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Publication Type J
Authors Kim, H. S., J. A. Kim, F. Karadeniz, B. N. Ahn and C. S. Kong
Title Radical Scavenging and Anti-Inflammatory Effects of the Halophyte Spergularia marina Griseb
Source Zeitschrift Fur Naturforschung Section C-a Journal of Biosciences
Author Keywords Antioxidant Anti-Inflammatory Free Radical Scavenger Spergularia marina Griseb ANTIMICROBIAL ACTIVITIES NATURAL ANTIOXIDANTS SALICORNIA-HERBACEA OXIDATIVE STRESS PLANT-EXTRACTS PURPUREA RATS DERIVATIVES MACROPHAGE DISEASE
Abstract As a part of ongoing research to develop antioxidant and anti-inflammatory nutraceuticals, an ethanolic extract of Spergularia marina Griseb. was tested for its ability to scavenge radicals and suppress inflammation. The extract was able to scavenge 1,1-dipheny1-2-picrylhydrazyl (DPPH), hydroxyl, and superoxide radicals, respectively, in cell-free environments as well as intracellular radicals in H2O2-stimulated mouse macrophages. Inflammation in mouse macrophages induced by lipopolysaccharides was suppressed by S. marina according to the measurement of nitric oxide generation and expression of inflammatory cytokines, i.e. tumour necrosis factor-alpha (TNF alpha), interleukin (IL)-1 beta, and IL-6. The anti-inflammatory effect of S. marina was substantiated by the finding that the expression of the inflammatory modulators, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), was significantly decreased. The chemical composition of S. marina was evaluated by FT-IR analysis of the extract indicating the presence of polyphenols and flavonoids. In conclusion, S. marina is suggested as a novel source for antioxidant and anti-inflammatory agents.
Author Address [Kim, Han Seong; Ahn, Byul-Nim] Pusan Natl Univ, Dept Organ Mat Sci & Engn, Busan, South Korea. [Kim, Jung-Ae; Kong, Chang-Suk] Silla Univ, Coll Med & Life Sci, Dept Food & Nutr, Busan 617736, South Korea. [Kim, Jung-Ae; Karadeniz, Fatih] Silla Univ, Marine Biotechnol Ctr Pharmaceut & Foods, Busan 617736, South Korea. Kong, CS (reprint author), Silla Univ, Coll Med & Life Sci, Dept Food & Nutr, Busan 617736, South Korea. cskong@silla.ac.kr
ISSN 0939-5075
ISBN 0939-5075
29-Character Source Abbreviation Z.Naturforsch.(C)
Publication Date Nov-Dec
Year Published 2014
Volume 69
Issue 11-12
Beginning Page 425-433
Digital Object Identifier (DOI) 10.5560/znc.2014-0098
Unique Article Identifier WOS:000352672200001
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