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| Publication Type | J |
| Authors | Rodrigues, M. J., K. N. Gangadhar, C. Vizetto-Duarte, S. G. Wubshet, N. T. Nyberg, L. Barreira, J. Varela and L. Custodio |
| Title | Maritime Halophyte Species from Southern Portugal as Sources of Bioactive Molecules |
| Source | Marine Drugs |
| Author Keywords | antioxidant anti-inflammatory cytotoxicity halophytes juncunol Juncus acutus edulis methanol extract antioxidant activity juncus-acutus arthrocnemum-macrostachyum antimicrobial activities staphylococcus-aureus plants stress growth cells |
| Abstract | Extracts of five halophytes from southern Portugal (Arthrocnemum macrostachyum, Mesembryanthemum edule, Juncus acutus, Plantago coronopus and Halimione portulacoides), were studied for antioxidant, anti-inflammatory and in vitro antitumor properties. The most active extracts towards the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical were the methanol extracts of M. edule (IC50 = 0.1 mg/mL) and J. acutus (IC50 = 0.4 mg/mL), and the ether extracts of J. acutus (IC50 = 0.2 mg/mL) and A. macrostachyum (IC50 = 0.3 mg/mL). The highest radical scavenging activity (RSA) against the 2,2-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical was obtained in the ether extract of J. acutus (IC50 = 0.4 mg/mL) and H. portulacoides (IC50 = 0.9 mg/mL). The maximum total phenolic content (TPC) was found in the methanol extract of M. edule (147 mg gallic acid equivalents (GAE)/g) and in the ether extract of J. acutus (94 mg GAE/g). Significant decreases in nitric oxide (NO) production were observed after incubation of macrophages with lipopolysaccharide (LPS) and the chloroform extract of H. portulacoides (IC50 = 109 mu g/mL) and the hexane extract of P. coronopus (IC50 = 98.0 mu g/mL). High in vitro cytotoxic activity and selectivity was obtained with the ether extract of J. acutus. Juncunol was identified as the active compound and for the first time was shown to display selective in vitro cytotoxicity towards various human cancer cells. |
| Author Address | [Rodrigues, Maria Joao; Gangadhar, Katkam N.; Vizetto-Duarte, Catarina; Barreira, Luisa; Varela, Joao; Custodio, Luisa] Univ Algarve, Fac Sci & Technol, Ctr Marine Sci, P-8005139 Faro, Portugal. [Gangadhar, Katkam N.] Univ Nova Lisboa, Inst Tecnol Quim & Biol, P-2780157 Oeiras, Portugal. [Wubshet, Sileshi G.; Nyberg, Nils T.] Univ Copenhagen, Fac Hlth & Med Sci, Dept Drug Design & Pharmacol, DK-2100 Copenhagen, Denmark. Custodio, L (reprint author), Univ Algarve, Fac Sci & Technol, Ctr Marine Sci, Ed 7,Campus Gambelas, P-8005139 Faro, Portugal. mary_p@sapo.pt; gangadharkatkam@gmail.com; catarina.vizetto@gmail.com; sgw@sund.ku.dk; nn@sund.ku.dk; lbarreir@ualg.pt; jvarela@ualg.pt; lcustodio@ualg.pt |
| ISSN | 1660-3397 |
| ISBN | 1660-3397 |
| 29-Character Source Abbreviation | Mar. Drugs |
| Publication Date | Apr |
| Year Published | 2014 |
| Volume | 12 |
| Issue | 4 |
| Beginning Page | 2228-2244 |
| Digital Object Identifier (DOI) | 10.3390/md12042228 |
| Unique Article Identifier | WOS:000335759500030 |
| Plants associated with this reference |