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Publication Type J
Authors Mohammed, S. A. A., H. M. Eldeeb, H. A. Mohammed, M. S. Al-Omar, S. A. Almahmoud, M. Z. El-Readi, E. A. Ragab, G. M. Sulaiman, M. S. A. Aly and R. A. Khan
Title Roles of Suaeda vermiculata Aqueous-Ethanolic Extract, Its Subsequent Fractions, and the Isolated Compounds in Hepatoprotection against Paracetamol-Induced Toxicity a s Compared to Silymarin
Source Oxidative Medicine and Cellular Longevity
Language English
Author Keywords acetaminophen-induced hepatotoxicity induced liver-injury oxidative stress lipid-peroxidation fatty liver tnf-alpha acid antioxidant medicine protection Cell Biology
Abstract Suaeda vermiculata, a halophyte consumed by livestock, is also used by Bedouins to manage liver disorders. The aqueous-ethanolic extract of S. vermiculata, its subsequent fractions, and pure compounds, i.e., pheophytin-A (1), isorhamnetin-3-O-rutinoside (2), and quercetin (3), were evaluated for their hepatoprotective efficacy. The male mice were daily fed with either silymarin, plant aq.-ethanolic extract, fractions, pure isolated compounds, or carboxyl methylcellulose (CMC) for 7 days (n = 6/group, p.o.). On the day 7th of the administrations, all, except the intact animal groups, were induced with hepatotoxicity using paracetamol (PCM, 300 mg/kg). The anesthetized animals were euthanized after 24 h; blood and liver tissues were collected and analysed. The serum aspartate transaminase (AST) and alanine transaminase (ALT) levels decreased significantly for all the S. vermiculata aq.-ethanolic extract, fraction, and compound-treated groups when equated with the PCM group (p < 0.0001). The antioxidant, superoxide dismutase (SOD), increased significantly (p < 0.05) for the silymarin-, n-hexane-, and quercetin-fed groups. Similarly, the catalase (CAT) enzyme level significantly increased for all the groups, except for the compound 2-treated group as compared to the CMC group. Also, the glutathione reductase (GR) levels were significantly increased for the n-butanol treated group than for the PCM group. The oxidative stress biomarkers, lipid peroxide (LP) and nitric oxide (NO), the inflammatory markers, IL-6 and TNF-alpha, and the kidney's functional biomarker parameters remained unchanged and did not differ significantly for the treated groups in comparison to the PCM-induced toxicity bearing animals. All the treated groups demonstrated significant decreases in cholesterol levels as compared to the PCM group, indicating hepatoprotective and antioxidant effects. The quercetin-treated group demonstrated significant improvement in triglyceride level. The S. vermiculata aq.-ethanolic extract, fractions, and the isolated compounds demonstrated their hepatoprotective and antioxidant effects, confirming the claimed traditional use of the herb as a liver protectant.
Author Address [Mohammed, Salman A. A.; Eldeeb, Hussein M.] Qassim Univ, Coll Pharm, Dept Pharmacol & Toxicol, Qasim 51452, Saudi Arabia. [Eldeeb, Hussein M.] Al Azhar Univ, Fac Med, Dept Biochem, Assiut 71524, Egypt. [Mohammed, Hamdoon A.; Al-Omar, Mohsen S.; Almahmoud, Suliman A.; Khan, Riaz A.] Qassim Univ, Coll Pharm, Dept Med Chem & Pharmacognosy, Qasim 51452, Saudi Arabia. [Mohammed, Hamdoon A.; Ragab, Ehab A.] Al Azhar Univ, Fac Pharm, Dept Pharmacognosy, Cairo 11371, Egypt. [Al-Omar, Mohsen S.] JUST, Dept Med Chem & Pharmacognosy, Fac Pharm, Irbid 22110, Jordan. [El-Readi, Mahmoud Z.] Umm Al Qura Univ, Fac Med, Dept Clin Biochem, Mecca 21955, Saudi Arabia. [El-Readi, Mahmoud Z.] Al Azhar Univ, Fac Pharm, Dept Biochem, Assiut 71524, Egypt. [Sulaiman, Ghassan M.] Univ Technol Baghdad, Dept Appl Sci, Div Biotechnol, Baghdad 10066, Iraq. [Aly, Mohamed S. A.] Hosp Police Acad, Cairo 11765, Egypt. Mohammed, HA; Khan, RA (corresponding author), Qassim Univ, Coll Pharm, Dept Med Chem & Pharmacognosy, Qasim 51452, Saudi Arabia.; Mohammed, HA (corresponding author), Al Azhar Univ, Fac Pharm, Dept Pharmacognosy, Cairo 11371, Egypt. ham.mohammed@qu.edu.sa; ri.khan@qu.edu.sa
ISSN 1942-0900
ISBN 1942-0900
29-Character Source Abbreviation Oxidative Med. Cell. Longev.
Publication Date Sep
Year Published 2021
Volume 2021
Beginning Page 10
Digital Object Identifier (DOI) 10.1155/2021/6174897
Unique Article Identifier WOS:000700358400001
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