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Publication Type J
Authors Janbaz, K. H., N. Aslam, I. Imran and Q. Jabeen
Title EVALUATION OF ANTI-INFLAMMATORY, ANALGESIC AND ANTIPYRETIC ACTIVITIES OF SALSOLA IMBRICATA FORSSK IN RATS
Source Journal of Animal and Plant Sciences-Japs
Language English
Author Keywords Chenopodiaceae carrageenan formalin test NaCl writhing test yeast induced pyrexia pain fever inflammation models Agriculture Life Sciences & Biomedicine - Other Topics Veterinary Sciences
Abstract Salsola imbricata has folkloric repute in the treatment of painful and inflammatory conditions. Therefore, present study was undertaken to assess the anti-inflammatory, analgesic and antipyretic activities of aqueous-ethanol crude extract of S. imbricata (Si.Cr) using models of carrageenan-induced paw edema, 4% NaCl-mediated abdominal writhing, formalininduced paw licking and brewer's yeast-mediated pyrexia in rats. The Si.Cr (100, 300 and 500 mg/kg, p.o.) significantly (p<0.001) inhibited carrageenan-induced paw edema in rats as compared to the saline treated control group. It inhibited writhes induced by intraperitoneal injection of 4% NaCl (p<0.001) as compared to the control group. In the first phase of formalin-induced paw licking test, Si.Cr (100 and 300 mg/kg) did not cause significant inhibition of nociception in rats, but at the dose of 500 mg/kg, it produced significant (p<0.05) reduction in time of licking paw by rats. Oral administration of Si.Cr (100, 300 and 500 mg/kg) reduced time of licking paw during the second phase of the formalin test. In addition, Si.Cr exhibited significant (p<0.001) antipyretic activity in brewer's yeast-induced pyrexia in rats. This study, showing the presence of anti-inflammatory, analgesic and antipyretic activities in Si.Cr, supports uses of the plant in folk medicine.
Author Address [Janbaz, K. H.; Aslam, N.; Imran, I.] Bahauddin Zakariya Univ, Dept Pharmacol, Fac Pharm, Multan, Pakistan. [Jabeen, Q.] Islamia Univ Bahawalpur, Fac Pharm & Alternat Med, Dept Pharm, Bahawalpur, Pakistan. Aslam, N (corresponding author), Bahauddin Zakariya Univ, Dept Pharmacol, Fac Pharm, Multan, Pakistan. naveedbwppk@yahoo.com
ISSN 1018-7081
ISBN 1018-7081
29-Character Source Abbreviation J. Anim. Plant Sci.-JAPS
Publication Date Jun
Year Published 2021
Volume 31
Issue 3
Beginning Page 862-867
Digital Object Identifier (DOI) 10.36899/japs.2021.3.0276
Unique Article Identifier WOS:000697050800024

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