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Publication Type J
Authors Bakhouche, I., T. Aliat, T. Boubellouta, L. Gali, A. Sen and Y. Bellik
Title Phenolic contents and in vitro antioxidant, anti-tyrosinase, and anti-inflammatory effects of leaves and roots extracts of the halophyte Limonium delicatulum
Source South African Journal of Botany
Language English
Author Keywords Limonium delicatulum Polyphenols Antioxidant activity Anti-tyrosinase activity Anti-inflammatory effect oxidative stress dietary polyphenols human health flavonoids mechanism plants inhibitors Plant Sciences
Abstract Limonium delicatulum is a halophyte growing in extreme conditions and therefore constituted a possible source of bioactive compounds. In the present study, total phenolic, flavonoids, and condensed tannins were quantified. DPPH, ABTS, Galvinoxyl radical (GOR), CUPRAC, reducing power, O-phenanthroline, silver nanoparticle, and beta-carotene bleaching assays were used to evaluate the antioxidant capacity. The inhibitory effect on tyrosinase activity and denaturation of BSA were also investigated. The results showed that extraction solvent, as well as plant organ, significantly influenced the contents of phenolic compounds. Methanolic roots extract contained the highest phenolic content with a value of 772.52 +/- 5.12 mu g GAE/mg consisting mainly of condensed tannins (678.87 +/- 0.11 mu g EC/mg of extract), while methanolic leaves extract recorded the highest content of flavonoids (212.77 +/- 1.19 mu g QE/mg extract). Methanolic extracts with high phenolic contents exerted the strongest antioxidant activity compared to the aqueous extracts. Moreover, methanolic roots extract exhibited high tyrosinase inhibition ability with an IC50 of 9.87 +/- 0.15 mu g/ml better than that of methanolic leaves extract and kojic acid (24.77 +/- 0.5 and 25.23 +/- 0.21 mu g/ml, respectively), The studied extracts also inhibited the denaturation of BSA in dose-dependent manner. Methanol extracts presented higher inhibition percentages than aqueous extracts and similar to that obtained with diclofenac sodium. L. delicatulum can be considered as a promising source of therapeutic bioactive compounds. (C) 2021 SAAB. Published by Elsevier B.V. All rights reserved.
Author Address [Bakhouche, Imene; Boubellouta, Tahar] Mohamed El Bachir El Ibrahimi Univ, Lab Characterizat & Valorizat Nat Resources, Bordj Bou Arreridj 3400, Algeria. [Bakhouche, Imene; Aliat, Toufik; Boubellouta, Tahar; Bellik, Yuva] Mohamed El Bachir El Ibrahimi Univ, Fac Life & Nat Sci, Bordj Bou Arreridj 34000, Algeria. [Gali, Lynda] Res Ctr Biotechnol, Ali Mendjli Nouvelle Ville UV 03,BP E73, Constantine, Algeria. [Sen, Ayse] Istanbul Univ, Fac Sci, Dept Biol, TR-34134 Istanbul, Turkey. Bellik, Y (corresponding author), Mohamed El Bachir El Ibrahimi Univ, Fac Life & Nat Sci, Bordj Bou Arreridj 34000, Algeria. y.bellik@univ-bba.dz
ISSN 0254-6299
ISBN 0254-6299
29-Character Source Abbreviation S. Afr. J. Bot.
Publication Date Jul
Year Published 2021
Volume 139
Beginning Page 42-49
Digital Object Identifier (DOI) 10.1016/j.sajb.2021.01.030
Unique Article Identifier WOS:000662214400007

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