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Authors Hussain, SM; Khan, A; Khan, AU; Qazi, NG; Ali, F
Author Full Name Hussain, Sayed Muzahir; Khan, Aslam; Khan, Arif-ullah; Qazi, Neelum Gul; Ali, Fawad
Title Pharmacological basis for medicinal use of Ziziphyus nummularia (Rhamnaceae) leaves in gastrointestinal disorders
Source TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
Language English
Document Type Article
Author Keywords Ziziphus nummularia; Anti-diarrheal; Anti-secretory; Anti-spasmodic; Anti-ulcer
Keywords Plus SMOOTH-MUSCLE; CALCIUM; ANTIDIARRHEAL; ANTIBACTERIAL; ANTIFUNGAL; ANTAGONIST; SECRETION; MECHANISM; MOTILITY; MODELS
Abstract Purpose: To explore the pharmacological basis for the folkloric use of Ziziphus nummularia for treating diarrhea and gastrointestinal spasm. Methods: Ziziphus nummularia crude extract (Zn.Cr) was investigated for antidiarrheal activity (50, 100 and 300 mg/kg) in terms of reduction diarrhea droppings as well as for antisecretory activity (300 and 1000 mg/kg) in castor-oil induced model in mice. The effect of the extract on potassium chloride (KCl, 80 mM)-induced contractions in isolated rabbit jejunum tissues were was also examined. Furthermore, the antiulcer properties of the extract was assessed in an ethanol-induced gastrointestinal ulcer model. Results: Zn.Cr (50 - 1000 mg/kg) exhibited protective effect against castor oil-induced diarrhea (p < 0.05, p < 0.01 vs saline group) and intestinal fluid accumulation (p < 0.001 vs. castor oil group) in mice. In isolated rabbit jejunum model, Zn.Cr concentration-dependently (0.01, 0.1, 0.3, 0.5, 1 and 3 mg/mL) caused relaxation of spontaneous and KCl-induced contractions, similar to verapamil. Calcium antagonistic effect was indicated, as pretreatment of intestinal tissues with Zn.Cr (0.3, 0.5 and 1.0 mg/mL) produced a rightward shift in Ca2+ concentration-response curves, with suppression of maximum contraction. In ethanol-induced gastric ulceration assay, Zn.Cr (300 and 1000 mg/kg) caused 52.5 and 93.6 % inhibition, respectively (p < 0.001 vs. saline group). Conclusion: These results reveal that Ziziphus nummularia possesses anti-diarrheal, anti-secretory, anti-spasmodic and anti-ulcer actions, mediated possibly through voltage-gated Ca2+channel blockade.
Author Address [Hussain, Sayed Muzahir; Khan, Arif-ullah; Qazi, Neelum Gul; Ali, Fawad] Riphah Int Univ, Riphah Inst Pharmaceut Sci, Dept Pharmacol, Islamabad, Pakistan; [Khan, Aslam] King Saud Bin Abdulaziz Univ Hlth Sci, Coll Sci & Hlth Profess, Basic Sci Dept, Jeddah, Saudi Arabia; [Ali, Fawad] Kohat Univ Sci & Technol, Dept Pharm, Kohat, Pakistan
Reprint Address Khan, A (corresponding author), King Saud Bin Abdulaziz Univ Hlth Sci, Coll Sci & Hlth Profess, Basic Sci Dept, Jeddah, Saudi Arabia.
E-mail Address khanasl@ksau-hs.edu.sa
ResearcherID Number Khan, Aslam/E-9393-2010
ORCID Number Khan, Aslam/0000-0003-3490-799X
Funding Agency and Grant Number Riphah Academy of Research and Education (RARE), Islamic International Medical College Trust, Riphah International University
Funding Text The authors are thankful to Riphah Academy of Research and Education (RARE), Islamic International Medical College Trust, Riphah International University for partial financial support of the study.
Times Cited 1
Total Times Cited Count (WoS, BCI, and CSCD) 1
Publisher PHARMACOTHERAPY GROUP
Publisher City BENIN CITY
Publisher Address UNIV BENIN, FACULTY PHARMACY, BENIN CITY, 00000, NIGERIA
ISSN 1596-5996
29-Character Source Abbreviation TROP J PHARM RES
ISO Source Abbreviation Trop. J. Pharm. Res.
Publication Date OCT
Year Published 2017
Volume 16
Issue 10
Beginning Page 2379
Ending Page 2385
Digital Object Identifier (DOI) 10.4314/tjpr.v16i10.10
Page Count 7
Web of Science Category Pharmacology & Pharmacy
Subject Category Pharmacology & Pharmacy
Document Delivery Number FQ6AN
Unique Article Identifier WOS:000418444800010
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