Loading content, please wait..
loading..
Logo
Version 3.22
or
Publication Type J
Authors Al-Omar, M. S., M. S. M. Sajid, N. S. Alnasyan, B. S. Almansour, R. M. Alruthaya, R. A. Khan, S. A. A. Mohammed, A. M. Al-Damigh and H. A. Mohammed
Title THE HALOPHYTIC PLANT, SUAEDA VERMICULATA FORSSK EXTRACTS REDUCE THE INFLAMED PAW EDEMA AND EXERT POTENTIAL ANTIMICROBIAL ACTIVITY
Source Pakistan Journal of Botany
Author Keywords Antimicrobial Anti-inflammatory beta sitosterol Halophytes Suaeda vermiculata oxidative stress salt tolerance inflammation antioxidant resistance
Abstract Background: Suaeda vermiculata is a halophytic plant widely distributed in central Saudi Arabia and traditionally used as a remedy for hepatitis, jaundice and viral infections. Objectives: The study aimed to inspect the phytochemical constituents and evaluate the antimicrobial activity of S. vermiculata different extracts against broad-spectrum microbial strains collected from human blood and urine samples. Anti-inflammatory activity of S. vermiculata is also investigated for the first time in this study. Methodology: Phytochemical constituents of S. vermiculata extracts were investigated by chemical tests and by using thin layer chromatography (TLC). Agar diffusion and minimal inhibitory concentration (MIC) methods were used to estimate the antimicrobial activity of S. vermiculata extracts. Anti-inflammatory effect of plant extracts was evaluated by Formalin-induced edema in rats' paw. Results: Phytochemical screening revealed the presence of tannins, flavonoids, alkaloids, saponins and sterols in the plant extracts. Tannins and flavonoids were strongly detected in ethanol and ethyl acetate while steroids were abundant in chloroform and n-hexane extracts. Among all extracts, the ethanol extract of S. vermiculata showed the best inhibition zone diameter (IZD) and MIC values against Candida albicans and Klebsiella pneumoniae with 12mm IZD (MIC 8.75mg/ml) and 13mm IZD (MIC 35mg/ml), respectively. Also, ethanol extract inhibits the growth of E. coli and Proteus vulgaris at MIC equal to 17.5mg/ml. All S. vermiculata extracts showed anti-inflammatory effect when they were compared with untreated vehicle group. Whereas, the anti-inflammatory activity observed for ethanol and ethyl acetate extracts were higher than diclofenac standard during all the intervals of the study. Conclusion: Ethanol extract of S. vermiculata showed potential antimicrobial activity with a remarkable anti-inflammatory effect which might be accounted for the phenolic and flavonoid constituents of the plant.
Author Address [Al-Omar, Mohsen S.; Almansour, Basma S.; Khan, Riaz A.; Mohammed, Hamdoon A.] Qassim Univ, Coll Pharm, Dept Med Chem & Pharmacognosy, Buraydah 51452, Saudi Arabia. [Al-Omar, Mohsen S.] Jordan Univ Sci & Technol, Coll Pharm, Dept Med Chem & Pharmacognosy, Irbid 22110, Jordan. [Sajid, Mohammed S. M.; Mohammed, Salman A. A.] Qassim Univ, Coll Pharm, Dept Pharmacol & Toxicol, Buraydah 51452, Saudi Arabia. [Alnasyan, Nada S.; Al-Damigh, Albaraa M.] Qassim Univ, Coll Pharm, Buraydah 51452, Saudi Arabia. [Alruthaya, Rana M.] Qassim Univ, Coll Appl Med Sci, Dept Med Microbiol, Buraydah 51452, Saudi Arabia. [Mohammed, Hamdoon A.] Al Azhar Univ, Fac Pharm, Dept Pharmacognosy, Cairo 11371, Egypt. Mohammed, HA (corresponding author), Qassim Univ, Coll Pharm, Dept Med Chem & Pharmacognosy, Buraydah 51452, Saudi Arabia.; Mohammed, HA (corresponding author), Al Azhar Univ, Fac Pharm, Dept Pharmacognosy, Cairo 11371, Egypt. ham.mohammed@qu.edu.sa
ISSN 0556-3321
ISBN 0556-3321
29-Character Source Abbreviation Pak. J. Bot.
Publication Date Feb
Year Published 2021
Volume 53
Issue 1
Beginning Page 351-356
Digital Object Identifier (DOI) 10.30848/pjb2021-1(9)
Unique Article Identifier WOS:000653078000021

LEGAL NOTICES — This website is protected by Copyright © The University of Sussex, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021. The eHALOPH database is protected by Database Right and Copyright © The University of Sussex and other contributors, 2006, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021. This database is based on an earlier work by James Aronson.
THIS WEBSITE AND THIS DATABASE ARE PROVIDED ON AN "AS IS" BASIS, AND YOU USE THEM AND RELY ON THEM AT YOUR OWN RISK.

Contact email: halophytes@sussex.ac.uk
Credits – Tim Flowers, Joaquim Santos, Moritz Jahns, Brian Warburton, Peter Reed