Loading content, please wait..
loading..
Logo
Version 3.22
or
Authors Bakr, RO; El-Behairy, MF; Elissawy, AM; Elimam, H; Fayed, MAA
Author Full Name Bakr, Riham O.; El-Behairy, Mohammed F.; Elissawy, Ahmed M.; Elimam, Hanan; Fayed, Marwa A. A.
Title New Adenosine Derivatives from Aizoon canariense L.: In Vitro Anticholinesterase, Antimicrobial, and Cytotoxic Evaluation of Its Extracts
Source MOLECULES
Language English
Document Type Article
Author Keywords Aizoon canariense; Aizoaceae; adenosine alkaloids; anticholinesterase; cytotoxicity; antimicrobial
Abstract Aizoaceae is a large succulent family characterized by many psychoactive species. Aizoon canariense L., a wild neglected plant traditionally used in gastrointestinal ailments, has been the subject of a limited number of phytochemical and biological studies. Therefore, herein, we investigated the in vitro cytotoxic, antimicrobial, and anticholinesteraseactivity of the aerial parts of A. canariense L. and analyzed the phytochemical compositions of the lipoidal and alkaloidal fractions. Petroleum ether extract showed the presence of behenic and tricosylic acid, while an in-depth investigation of the alkaloidal fraction revealed the identification of new adenine based alkaloids (1-5), which were isolated and identified for the first time from Aizoon canariense L. Their structures were elucidated based on extensive spectroscopic analyses. The alkaloidal extract showed a powerful cytotoxic effect (IC50 14-28 mu g/mL), with the best effect against colon carcinoma, followed by liver and breast carcinomas. The alkaloidal extract also had a potent effect against Candida albicans and Escherichia coli, with minimum inhibitory concentrations (MIC) values of 312.5 and 625 mu g/mL. The in vitro anticholinesterase activity was potent, with IC50 < 200 ng/mL for the tested extracts compared with 27.29 +/- 0.49 ng/mL for tacrine.
Author Address [Bakr, Riham O.] October Univ Modern Sci & Arts MSA, Dept Pharmacognosy, Fac Pharm, Giza 11787, Egypt; [El-Behairy, Mohammed F.] Univ Sadat City, Dept Organ & Med Chem, Fac Pharm, Sadat 32897, Egypt; [Elissawy, Ahmed M.] Ain Shams Univ, Dept Pharmacognosy, Fac Pharm, Cairo 11566, Egypt; [Elissawy, Ahmed M.] Ain Shams Univ, Ctr Drug Discovery Res & Dev, Cairo, Egypt; [Elimam, Hanan] Univ Sadat City, Dept Biochem, Fac Pharm, Sadat 32897, Egypt; [Fayed, Marwa A. A.] Univ Sadat City, Dept Pharmacognosy, Fac Pharm, Sadat 32897, Egypt
Reprint Address Fayed, MAA (corresponding author), Univ Sadat City, Dept Pharmacognosy, Fac Pharm, Sadat 32897, Egypt.
E-mail Address romar@msa.eun.eg; mohammed.farrag@fop.usc.edu.eg; aelissawy@pharma.asu.edu.eg; Hanan.Elimam@fop.usc.edu.eg; marwa.fayed@fop.usc.edu.eg
ResearcherID Number Fayed, Marwa A.A./G-3960-2017; Elimam, Hanan/H-5858-2017; El-Behairy, Mohammed Farrag/N-9327-2016
ORCID Number Fayed, Marwa A.A./0000-0001-5609-7436; Elimam, Hanan/0000-0003-2585-9957; El-Behairy, Mohammed Farrag/0000-0001-7843-1423
Times Cited 1
Total Times Cited Count (WoS, BCI, and CSCD) 1
Publisher MDPI
Publisher City BASEL
Publisher Address ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
29-Character Source Abbreviation MOLECULES
ISO Source Abbreviation Molecules
Publication Date MAR
Year Published 2021
Volume 26
Issue 5
Article Number 1198
Digital Object Identifier (DOI) 10.3390/molecules26051198
Page Count 14
Web of Science Category Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
Subject Category Biochemistry & Molecular Biology; Chemistry
Document Delivery Number QW1IY
Unique Article Identifier WOS:000628412500001
Plants associated with this reference

LEGAL NOTICES — This website is protected by Copyright © The University of Sussex, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021. The eHALOPH database is protected by Database Right and Copyright © The University of Sussex and other contributors, 2006, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021. This database is based on an earlier work by James Aronson.
THIS WEBSITE AND THIS DATABASE ARE PROVIDED ON AN "AS IS" BASIS, AND YOU USE THEM AND RELY ON THEM AT YOUR OWN RISK.

Contact email: halophytes@sussex.ac.uk
Credits – Tim Flowers, Joaquim Santos, Moritz Jahns, Brian Warburton, Peter Reed