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Authors Men, RZ; Li, N; Xing, YC; Tang, YZ; Tan, CY; Meng, FT; Zhang, J; Ni, H; Jia, XG
Author Full Name Men, Ruizhi; Li, Ning; Xing, Yachao; Tang, Yingzhan; Tan, Chengyu; Meng, Fantong; Zhang, Juan; Ni, Hui; Jia, Xiaoguang
Title Chemical constituents and ACE inhibitory activity of desert plant Suaeda physophora Pall.
Source ACTA PHARMACEUTICA SINICA B
Language English
Document Type Article
Author Keywords Desert plan; Suaeda physophoa Pall.; Chemical constituents; ACE inhibitory activity
Abstract Suaeda physophora Pall. is a kind of desert plant mostly growing in saline habitats in Xinjiang Uygur Autonomous Region. In order to have a better utilization of halophytes, a screening for ACE inhibitors from halophytes growing in Xinjiang was carried out. The result showed that the 707 Et0H extract and n-BuOH extract of S. physophora Pall possessed significant ACE inhibitory activities. So we focused on its biochemical constituents firstly. One new quinazoline alkaloid, namely Suaedine (1), along with six known compounds (2-7) was isolated from the aerial parts of S. physophora Pall. The structure of the new quinazoline alkaloid was established by one- and two-dimensional nuclear magnetic resonance, optical rotation and mass spectrometry analysis. The fiavonoid compounds (2-1) and phenolic compound (5) exhibited significant ACE activities. It was the first time to focus on the chemical constituents and bioactivities of this plant. (C) 2013 Institute of Materia Medical, Chinese Academy of Medical Sciences and Chinese Pharmaceutical Association. Production and hosting by Elsevier B.V. All rights reserved.
Author Address [Men, Ruizhi; Li, Ning; Xing, Yachao; Tang, Yingzhan] Shenyang Pharmaceut Univ, Sch Tradit Chinese Med, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China; [Tan, Chengyu; Meng, Fantong] Dalian Ocean Univ, Marine Environm Engn Coll, Dalian 116023, Peoples R China; [Zhang, Juan; Ni, Hui; Jia, Xiaoguang] Xinjiang Inst Chinese Mat Med & Eihnodrug, Urumqi 830002, Peoples R China
Reprint Address Li, N (corresponding author), Shenyang Pharmaceut Univ, Sch Tradit Chinese Med, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China.
E-mail Address liningsypharm@163.com
ORCID Number Li, Ning/0000-0002-6518-2541
Funding Agency and Grant Number National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81001371]; Science and Technology Foundation of Dalian city [2011J21DW012]
Funding Text This work was supported by the National Natural Science Foundation of China (81001371), and the Science and Technology Foundation of Dalian city (2011J21DW012).
Times Cited 5
Total Times Cited Count (WoS, BCI, and CSCD) 5
Publisher INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
Publisher City BEIJING
Publisher Address C/O EDITORIAL BOARD OF ACTA PHARMACEUTICA SINICA, 1 XIANNONGTAN ST, BEIJING, 100050, PEOPLES R CHINA
ISSN 2211-3835
29-Character Source Abbreviation ACTA PHARM SIN B
ISO Source Abbreviation Acta Pharm. Sin. B
Publication Date SEP
Year Published 2013
Volume 3
Issue 5
Beginning Page 328
Ending Page 332
Digital Object Identifier (DOI) 10.1016/j.apsb.2013.07.003
Page Count 5
Web of Science Category Pharmacology & Pharmacy
Subject Category Pharmacology & Pharmacy
Document Delivery Number VB1FF
Unique Article Identifier WOS:000413451700005
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