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| Authors | SAUTER, G; BEUERS, U; PAUMGARTNER, G |
| Author Full Name | SAUTER, G; BEUERS, U; PAUMGARTNER, G |
| Title | EFFECT OF DIETARY FIBER ON SERUM BILE-ACIDS IN PATIENTS WITH CHRONIC CHOLESTATIC LIVER-DISEASE UNDER URSODEOXYCHOLIC ACID THERAPY |
| Source | DIGESTION |
| Language | English |
| Document Type | Article |
| Author Keywords | BILE SALT METABOLISM; CHRONIC CHOLESTATIC LIVER DISEASE; DIETARY FIBERS; URSODEOXYCHOLIC ACID |
| Keywords Plus | PRIMARY BILIARY-CIRRHOSIS; JUVENILE ULCERATIVE-COLITIS; CONTROLLED TRIAL; PLANTAGO-OVATA; CHOLESTEROL; HEPATOCYTES; EXCRETION; SALTS |
| Abstract | During ursodeoxycholic acid therapy for chronic cholestatic liver disease, the serum levels of lithocholic acid increase about twofold. Lithocholic acid has been shown to be hepatotoxic in some animal species. Administration of psyllium hydrophilic mucilloid (PHM), a dietary fiber, has been reported to increase the bile acid mass excreted by the feces. We, therefore, studied the effect of PHM (3 x 3.25 g/day) on serum bile acids including lithocholic acid in 12 patients with primary sclerosing cholangitis (n = 7) and primary biliary cirrhosis (n = 5) receiving ursodeoxycholic acid therapy. After 2 and 6 weeks of treatment with PHM, the serum levels of ursodeoxycholic acid increased by 52.4 +/- 72.8% (p < 0.05) and 40.5 +/- 69.6% (NS), respectively. The absolute serum levels of lithocholic acid were not significantly changed. This led to a decrease of the relative amount of lithocholic acid as referred to total bile acids and to ursodeoxycholic acid in serum by 27.4 +/- 34.5% (p < 0.05) and 25.5 +/- 32.8% (p < 0.05), respectively, after 6 weeks of PHM treatment. |
| Reprint Address | SAUTER, G (corresponding author), UNIV MUNICH,KLINIKUM GROSSHADERN,DEPT MED 2,MARCHIONINISTR 15,D-81377 MUNICH,GERMANY. |
| Times Cited | 4 |
| Total Times Cited Count (WoS, BCI, and CSCD) | 4 |
| Publisher | KARGER |
| Publisher City | BASEL |
| Publisher Address | ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND |
| ISSN | 0012-2823 |
| 29-Character Source Abbreviation | DIGESTION |
| ISO Source Abbreviation | Digestion |
| Publication Date | NOV-DEC |
| Year Published | 1995 |
| Volume | 56 |
| Issue | 6 |
| Beginning Page | 523 |
| Ending Page | 527 |
| Digital Object Identifier (DOI) | 10.1159/000201286 |
| Page Count | 5 |
| Web of Science Category | Gastroenterology & Hepatology |
| Subject Category | Gastroenterology & Hepatology |
| Document Delivery Number | TC302 |
| Unique Article Identifier | WOS:A1995TC30200012 |
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