Loading content, please wait..
loading..
Logo
Version 3.21
or
Authors SAUTER, G; BEUERS, U; PAUMGARTNER, G
Author Full Name SAUTER, G; BEUERS, U; PAUMGARTNER, G
Title EFFECT OF DIETARY FIBER ON SERUM BILE-ACIDS IN PATIENTS WITH CHRONIC CHOLESTATIC LIVER-DISEASE UNDER URSODEOXYCHOLIC ACID THERAPY
Source DIGESTION
Language English
Document Type Article
Author Keywords BILE SALT METABOLISM; CHRONIC CHOLESTATIC LIVER DISEASE; DIETARY FIBERS; URSODEOXYCHOLIC ACID
Keywords Plus PRIMARY BILIARY-CIRRHOSIS; JUVENILE ULCERATIVE-COLITIS; CONTROLLED TRIAL; PLANTAGO-OVATA; CHOLESTEROL; HEPATOCYTES; EXCRETION; SALTS
Abstract During ursodeoxycholic acid therapy for chronic cholestatic liver disease, the serum levels of lithocholic acid increase about twofold. Lithocholic acid has been shown to be hepatotoxic in some animal species. Administration of psyllium hydrophilic mucilloid (PHM), a dietary fiber, has been reported to increase the bile acid mass excreted by the feces. We, therefore, studied the effect of PHM (3 x 3.25 g/day) on serum bile acids including lithocholic acid in 12 patients with primary sclerosing cholangitis (n = 7) and primary biliary cirrhosis (n = 5) receiving ursodeoxycholic acid therapy. After 2 and 6 weeks of treatment with PHM, the serum levels of ursodeoxycholic acid increased by 52.4 +/- 72.8% (p < 0.05) and 40.5 +/- 69.6% (NS), respectively. The absolute serum levels of lithocholic acid were not significantly changed. This led to a decrease of the relative amount of lithocholic acid as referred to total bile acids and to ursodeoxycholic acid in serum by 27.4 +/- 34.5% (p < 0.05) and 25.5 +/- 32.8% (p < 0.05), respectively, after 6 weeks of PHM treatment.
Reprint Address SAUTER, G (corresponding author), UNIV MUNICH,KLINIKUM GROSSHADERN,DEPT MED 2,MARCHIONINISTR 15,D-81377 MUNICH,GERMANY.
Times Cited 4
Total Times Cited Count (WoS, BCI, and CSCD) 4
Publisher KARGER
Publisher City BASEL
Publisher Address ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
ISSN 0012-2823
29-Character Source Abbreviation DIGESTION
ISO Source Abbreviation Digestion
Publication Date NOV-DEC
Year Published 1995
Volume 56
Issue 6
Beginning Page 523
Ending Page 527
Digital Object Identifier (DOI) 10.1159/000201286
Page Count 5
Web of Science Category Gastroenterology & Hepatology
Subject Category Gastroenterology & Hepatology
Document Delivery Number TC302
Unique Article Identifier WOS:A1995TC30200012
Plants associated with this reference

LEGAL NOTICES — This website is protected by Copyright © The University of Sussex, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021. The eHALOPH database is protected by Database Right and Copyright © The University of Sussex and other contributors, 2006, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021. This database is based on an earlier work by James Aronson.
THIS WEBSITE AND THIS DATABASE ARE PROVIDED ON AN "AS IS" BASIS, AND YOU USE THEM AND RELY ON THEM AT YOUR OWN RISK.

Contact email: halophytes@sussex.ac.uk
Credits – Tim Flowers, Joaquim Santos, Moritz Jahns, Brian Warburton, Peter Reed