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Authors Erum, A; Bashir, S; Saghir, S
Author Full Name Erum, Alia; Bashir, Sajid; Saghir, Shazia
Title Modified and unmodified arabinoxylans from Plantago ovata husk: Novel excipients with antimicrobial potential
Source BANGLADESH JOURNAL OF PHARMACOLOGY
Language English
Document Type Article
Keywords Plus CARBOXYMETHYLATION
Abstract Arabinoxylan is a polysaccharide of Plantago ovata, an indigenous plant of Pakistan and several European countries. In the present investigation arabinoxylan isolated from P. ovata husk was chemically modified i.e., carboxymethylated and was converted into its sodium salt. Physicochemical characterization of modified arabinoxylans was done. The antimicrobial assay of arabinoxylan and modified arabinoxylans was done by Kirby-Bauer disk diffusion method against Gram negative and Gram positive bacterial strains. Physicochemical properties of modified arabinoxylans were different from arabinoxylan yet were satisfactory for their use as pharmaceutical excipients. Arabinoxylan showed strong antimicrobial activity against Gram positive strains. However, it showed no antimicrobial activity against Gram negative strains. Carboxymethyl arabinoxylan showed maximum activity against S. epidermidis. It also showed activity against S. aureus and P. aeruginosa. Arabinoxylan Na showed concentration-dependent antimicrobial activity. This study provides the first report on the antibacterial properties of arabinoxylan and its modified forms.
Author Address [Erum, Alia; Bashir, Sajid] Univ Sargodha, Fac Pharm, Sargodha, Pakistan; [Saghir, Shazia] Govt Jinnah Degree Coll Women, Dept Chem, Lahore, Pakistan
Reprint Address Erum, A (corresponding author), Univ Sargodha, Fac Pharm, Sargodha, Pakistan.
E-mail Address erum@hotmail.com
ResearcherID Number Erum, Alia/K-8435-2019; Bashir, Sajid/J-4266-2019
Times Cited 6
Total Times Cited Count (WoS, BCI, and CSCD) 6
Publisher BANGLADESH PHARMACOLOGICAL SOC
Publisher City SHAHBAH
Publisher Address BANGABANDHU SHEIKH MUJIB MED UNIV, DEPT PHARMACOL, SHAHBAH, DHAKA 1000, BANGLADESH
ISSN 1991-007X
29-Character Source Abbreviation BANGL J PHARMACOL
ISO Source Abbreviation Bangladesh J. Pharmacol.
Year Published 2015
Volume 10
Issue 4
Beginning Page 765
Ending Page 769
Digital Object Identifier (DOI) 10.3329/bjp.v10i4.23788
Page Count 5
Web of Science Category Pharmacology & Pharmacy
Subject Category Pharmacology & Pharmacy
Document Delivery Number CY8KK
Unique Article Identifier WOS:000366657100006
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