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Authors Patel, MK; Tanna, B; Mishra, A; Jha, B
Author Full Name Patel, Manish Kumar; Tanna, Bhakti; Mishra, Avinash; Jha, Bhavanath
Title Physicochemical characterization, antioxidant and anti-proliferative activities of a polysaccharide extracted from psyllium (P. ovata) leaves
Source INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Language English
Document Type Article
Author Keywords Anticancer; Antioxidant; Bioactivity; Isabgol; Polysaccharide
Keywords Plus EXTRACELLULAR POLYMERIC SUBSTANCES; MICROALGAE DUNALIELLA-SALINA; STRUCTURAL-CHARACTERIZATION; BIOLOGICAL-ACTIVITIES; SALICORNIA-BRACHIATA; SCAVENGING ACTIVITY; ANTICANCER ACTIVITY; L. LEAVES; PLANTAGO; GUM
Abstract Psyllium leaves polysaccharides were physicochemically characterized and evaluated for antioxidant, free-radical scavenging and anticancer activities. The polysaccharide comprised of arabinose, rhamnose, xylose, galactose, and glucose. FTIR and NMR study exhibited the presence of key functional groups whereas morphological study revealed that crude polysaccharides are aggregates of irregular shape, non-porous, and smooth surface, while the purified products are porous and fibrous in nature. Extracted polysaccharides were thermally stable and exhibited the characteristic diffraction curve with a higher viscosity and size distribution. Biochemical analyses demonstrated the higher antioxidant and scavenging activities. In vitro anticancer assay showed the maximum inhibitory effect about 33% on Huh7 and about 30% on HeLa cell lines. The study confirmed the presence of high antioxidant and free-radical scavenging activities with a potential anticancer activity. The polysaccharide could be developed as a potential natural antioxidant and anticancer agents after comprehensive studies on experimental animal models. (C) 2018 Elsevier B.V. All rights reserved.
Author Address [Patel, Manish Kumar; Tanna, Bhakti; Mishra, Avinash; Jha, Bhavanath] Cent Salt & Marine Chem Res Inst, CSIR, Biotechnol & Phycol Div, GB Marg, Bhavnagar 364002, Gujarat, India; [Tanna, Bhakti; Mishra, Avinash; Jha, Bhavanath] Anusandhan Bhavan, Acad Sci & Innovat Res, CSIR, Rafi Marg, New Delhi 110001, India; [Patel, Manish Kumar] Natl Inst Plant Genome Res, Aruna Asaf Ali Marg, New Delhi 110067, India
Reprint Address Mishra, A; Jha, B (corresponding author), Cent Salt & Marine Chem Res Inst, CSIR, Biotechnol & Phycol Div, GB Marg, Bhavnagar 364002, Gujarat, India.
E-mail Address avinash@csmcri.res.in; jha.bhavanath@gmail.com
ResearcherID Number Mishra, Avinash/AAG-2961-2019; Mishra, Avinash/C-3210-2009
ORCID Number Mishra, Avinash/0000-0003-0342-010X; Mishra, Avinash/0000-0003-0342-010X; TANNA, BHAKTI/0000-0003-3958-9791
Funding Agency and Grant Number CSIR-CSMCRICouncil of Scientific & Industrial Research (CSIR) - India [PRIS-151/2017]
Funding Text CSIR-CSMCRI Communication No.: PRIS-151/2017. Analytical and Environmental Science Division and Centralized Instrument Facility of the institute is duly acknowledged for helping in running samples for the analytical analysis.
Times Cited 19
Total Times Cited Count (WoS, BCI, and CSCD) 19
Publisher ELSEVIER SCIENCE BV
Publisher City AMSTERDAM
Publisher Address PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
ISSN 0141-8130
29-Character Source Abbreviation INT J BIOL MACROMOL
ISO Source Abbreviation Int. J. Biol. Macromol.
Publication Date OCT 15
Year Published 2018
Volume 118
Part Number A
Beginning Page 976
Ending Page 987
Digital Object Identifier (DOI) 10.1016/j.ijbiomac.2018.06.139
Page Count 12
Web of Science Category Biochemistry & Molecular Biology; Chemistry, Applied; Polymer Science
Subject Category Biochemistry & Molecular Biology; Chemistry; Polymer Science
Document Delivery Number GU3IQ
Unique Article Identifier WOS:000445170200109
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