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| Authors | Patel, MK; Tanna, B; Mishra, A; Jha, B |
| Author Full Name | Patel, Manish Kumar; Tanna, Bhakti; Mishra, Avinash; Jha, Bhavanath |
| Title | Physicochemical characterization, antioxidant and anti-proliferative activities of a polysaccharide extracted from psyllium (P. ovata) leaves |
| Source | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES |
| Language | English |
| Document Type | Article |
| Author Keywords | Anticancer; Antioxidant; Bioactivity; Isabgol; Polysaccharide |
| Keywords Plus | EXTRACELLULAR POLYMERIC SUBSTANCES; MICROALGAE DUNALIELLA-SALINA; STRUCTURAL-CHARACTERIZATION; BIOLOGICAL-ACTIVITIES; SALICORNIA-BRACHIATA; SCAVENGING ACTIVITY; ANTICANCER ACTIVITY; L. LEAVES; PLANTAGO; GUM |
| Abstract | Psyllium leaves polysaccharides were physicochemically characterized and evaluated for antioxidant, free-radical scavenging and anticancer activities. The polysaccharide comprised of arabinose, rhamnose, xylose, galactose, and glucose. FTIR and NMR study exhibited the presence of key functional groups whereas morphological study revealed that crude polysaccharides are aggregates of irregular shape, non-porous, and smooth surface, while the purified products are porous and fibrous in nature. Extracted polysaccharides were thermally stable and exhibited the characteristic diffraction curve with a higher viscosity and size distribution. Biochemical analyses demonstrated the higher antioxidant and scavenging activities. In vitro anticancer assay showed the maximum inhibitory effect about 33% on Huh7 and about 30% on HeLa cell lines. The study confirmed the presence of high antioxidant and free-radical scavenging activities with a potential anticancer activity. The polysaccharide could be developed as a potential natural antioxidant and anticancer agents after comprehensive studies on experimental animal models. (C) 2018 Elsevier B.V. All rights reserved. |
| Author Address | [Patel, Manish Kumar; Tanna, Bhakti; Mishra, Avinash; Jha, Bhavanath] Cent Salt & Marine Chem Res Inst, CSIR, Biotechnol & Phycol Div, GB Marg, Bhavnagar 364002, Gujarat, India; [Tanna, Bhakti; Mishra, Avinash; Jha, Bhavanath] Anusandhan Bhavan, Acad Sci & Innovat Res, CSIR, Rafi Marg, New Delhi 110001, India; [Patel, Manish Kumar] Natl Inst Plant Genome Res, Aruna Asaf Ali Marg, New Delhi 110067, India |
| Reprint Address | Mishra, A; Jha, B (corresponding author), Cent Salt & Marine Chem Res Inst, CSIR, Biotechnol & Phycol Div, GB Marg, Bhavnagar 364002, Gujarat, India. |
| E-mail Address | avinash@csmcri.res.in; jha.bhavanath@gmail.com |
| ResearcherID Number | Mishra, Avinash/AAG-2961-2019; Mishra, Avinash/C-3210-2009 |
| ORCID Number | Mishra, Avinash/0000-0003-0342-010X; Mishra, Avinash/0000-0003-0342-010X; TANNA, BHAKTI/0000-0003-3958-9791 |
| Funding Agency and Grant Number | CSIR-CSMCRICouncil of Scientific & Industrial Research (CSIR) - India [PRIS-151/2017] |
| Funding Text | CSIR-CSMCRI Communication No.: PRIS-151/2017. Analytical and Environmental Science Division and Centralized Instrument Facility of the institute is duly acknowledged for helping in running samples for the analytical analysis. |
| Times Cited | 19 |
| Total Times Cited Count (WoS, BCI, and CSCD) | 19 |
| Publisher | ELSEVIER SCIENCE BV |
| Publisher City | AMSTERDAM |
| Publisher Address | PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS |
| ISSN | 0141-8130 |
| 29-Character Source Abbreviation | INT J BIOL MACROMOL |
| ISO Source Abbreviation | Int. J. Biol. Macromol. |
| Publication Date | OCT 15 |
| Year Published | 2018 |
| Volume | 118 |
| Part Number | A |
| Beginning Page | 976 |
| Ending Page | 987 |
| Digital Object Identifier (DOI) | 10.1016/j.ijbiomac.2018.06.139 |
| Page Count | 12 |
| Web of Science Category | Biochemistry & Molecular Biology; Chemistry, Applied; Polymer Science |
| Subject Category | Biochemistry & Molecular Biology; Chemistry; Polymer Science |
| Document Delivery Number | GU3IQ |
| Unique Article Identifier | WOS:000445170200109 |
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