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Authors Farzadinia, P; Mohebbi, G; Bargahi, A; Akbarzadeh, S; Nabipour, I; Abdi, M; Hasanpour, Z; Alipour, Z; Daneshi, A
Author Full Name Farzadinia, Parviz; Mohebbi, Gholamhossein; Bargahi, Afshar; Akbarzadeh, Samad; Nabipour, Iraj; Abdi, Mohammadreza; Hasanpour, Zeynab; Alipour, Zahra; Daneshi, Adel
Title Healing effects of Pergularia tomentosa L., a native medicinal plant in Bushehr province, Iran on burn, in animal model
Source PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
Language English
Document Type Article
Author Keywords Pergularia tomentosa L.; burn injury; therapeutic effect
Keywords Plus ANTIBACTERIAL; EPIDEMIOLOGY; MECHANISM; EXTRACTS; LEAVES; SILVER; SKIN
Abstract Burn injury is one of the most destructive events in the world. The Pergularia tomentosa L. is a medicinal plant that traditionally, applies for treatment of burning, in Bushehr province, Iran. Various bioactive compounds such as steroid glycosides, tannins, various vitamins, saponins, cardenolides and anthraquinones were identified into extract of the plant, which can be effective in burn wound healing. Twenty-one rats weighting every one 200 +/- 5 grams were divided equally into three groups. The second-degree burning induced on all groups. One of groups did not receive any treatment (The control group) and was treated locally with saline and eucerin. The Second group received the P tomentosa L. as a topical ointment, and the third group received locally, a thin layer of silver sulfadiazine ointment 3% after washing the wound with saline. Afterward treatment period, the microscopic slides from histological sections were prepared. At that point, amounts of the fibroblast cells, blood vessels, wound area, necrotic tissues, and diameter of epidermis rate of wound healing were determined. Also the exterior status of wound in different days was considered. Results obtained from current study have revealed that the extract of P. tomentosa L. can significantly, cause qualitative and quantitative acceleration in healing of second degree burn wounds, due to their bioactive and vasoactive properties. In conclusion the P. tomentosa L. can is used as an overborne medicine with lower cost and side effect than the similar chemical medicines. Although, the further studies are needed on these plants, due to their some toxic effects.
Author Address [Farzadinia, Parviz] Bushehr Univ Med Sci, Dept Anat, Sch Med, Bushehr, Iran; [Mohebbi, Gholamhossein; Bargahi, Afshar; Nabipour, Iraj; Abdi, Mohammadreza; Hasanpour, Zeynab; Alipour, Zahra; Daneshi, Adel] Bushehr Univ Med Sci, Dept Marine Toxinol, Persian Gulf Marine Biotechnol Res Ctr, Bushehr, Iran; [Mohebbi, Gholamhossein] Bushehr Univ Med Sci, Food & Drug Dept, Bushehr, Iran; [Akbarzadeh, Samad] Bushehr Univ Med Sci, Dept Biochem, Sch Med, Bushehr, Iran
Reprint Address Daneshi, A (corresponding author), Bushehr Univ Med Sci, Dept Marine Toxinol, Persian Gulf Marine Biotechnol Res Ctr, Bushehr, Iran.
E-mail Address adel_daneshi1@yahoo.com
Publisher UNIV KARACHI
Publisher City KARACHI
Publisher Address UNIV CAMPUS, FAC PHARMACY, KARACHI, 75270, PAKISTAN
ISSN 1011-601X
29-Character Source Abbreviation PAK J PHARM SCI
ISO Source Abbreviation Pak. J. Pharm. Sci.
Publication Date JAN
Year Published 2019
Volume 32
Issue 1
Beginning Page 21
Ending Page 28
Page Count 8
Web of Science Category Pharmacology & Pharmacy
Subject Category Pharmacology & Pharmacy
Document Delivery Number HO3TX
Unique Article Identifier WOS:000460846900004
Plants associated with this reference

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