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Authors Thoppil, RJ; Harlev, E; Mandal, A; Nevo, E; Bishayee, A
Author Full Name Thoppil, Roslin J.; Harlev, Eli; Mandal, Animesh; Nevo, Eviatar; Bishayee, Anupam
Title Antitumor activities of extracts from selected desert plants against HepG2 human hepatocellular carcinoma cells
Source PHARMACEUTICAL BIOLOGY
Language English
Document Type Article
Author Keywords Achillea fragrantissima; antiproliferative effect; HCC; Ochradenus baccatus; Origanum dayi; Phlomis platystegia; Varthemia iphionoides
Keywords Plus ACHILLEA-FRAGRANTISSIMA; VARTHEMIA-IPHIONOIDES; NATURAL-PRODUCTS; ESSENTIAL OIL; ANTIOXIDANT; FLAVONOIDS; MEDICINE; JORDAN
Abstract Context: Phytochemicals are produced by desert plants to protect themselves against stressful environments. They have been shown to be useful in preventing and fighting adverse pathophysiological conditions and complex diseases, including cancer. Although many desert plants have been investigated for their antitumor properties, a large number of them still remain to be explored for possible therapeutic applications in oncologic diseases. Objective: To screen the antitumor effects of selected desert plants, namely Achillea fragrantissima (Forssk.) Sch. Bip. (Compositae), Ochradenus baccatus Delile (Resedaceae), Origanum dayi Post (Lamiaceae), Phlomis platystegia Post (Lamiaceae) and Varthemia iphionoides Boiss (Compositae), against an in vitro tumor model utilizing HepG2 human hepatocellular carcinoma cells. Materials and methods: The aqueous extracts of aerial parts of the aforementioned plants were prepared and used for the in vitro experiments. The HepG2 cells were exposed to varying concentrations (0-4 mg/mL) of each plant extract for 24 or 48 h and the cytotoxicity was measured by the MU assay. Results: Following 24 h exposure, O. dayi extract exhibited a substantial antiproliferative effect in HepG2 cells (IC50=1.0 mg/mL) followed by O. baccatus (IC50=1.5 mg/mL). All plant extracts displayed cytotoxicity following 48 h exposure. Nevertheless, a substantial effect was observed with O. dayi (IC50=0.35 mg/mL) or O. baccatus (IC50=0.83 mg/mL). Conclusion: The aqueous extracts from aerial parts of O. dayi and O. baccatus possess antitumor effects against human liver cancer cells. These desert plants represent valuable resources for the development of potential anticancer agents.
Author Address [Thoppil, Roslin J.; Mandal, Animesh] Northeast Ohio Med Univ, Coll Pharm, Dept Pharmaceut Sci, Canc Therapeut & Chemoprevent Grp, Rootstown, OH USA; [Harlev, Eli; Nevo, Eviatar] Univ Haifa, Inst Evolut, IL-31999 Haifa, Israel; [Harlev, Eli; Nevo, Eviatar] Univ Haifa, Int Grad Ctr Evolut, IL-31999 Haifa, Israel; [Bishayee, Anupam] Amer Univ Hlth Sci, Sch Pharm, Dept Pharmaceut Sci, Signal Hill, CA 90755 USA
Reprint Address Bishayee, A (corresponding author), Amer Univ Hlth Sci, Sch Pharm, Dept Pharmaceut Sci, 1600 East Hill St, Signal Hill, CA 90755 USA.
E-mail Address abishayee@auhs.edu
Times Cited 15
Total Times Cited Count (WoS, BCI, and CSCD) 16
Publisher TAYLOR & FRANCIS LTD
Publisher City ABINGDON
Publisher Address 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
ISSN 1388-0209
29-Character Source Abbreviation PHARM BIOL
ISO Source Abbreviation Pharm. Biol.
Publication Date MAY
Year Published 2013
Volume 51
Issue 5
Beginning Page 668
Ending Page 674
Digital Object Identifier (DOI) 10.3109/13880209.2012.749922
Page Count 7
Web of Science Category Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
Subject Category Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
Document Delivery Number 136WL
Unique Article Identifier WOS:000318394000021
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