Loading content, please wait..
loading..
Logo
Version 3.22
or
Authors Al-Omar, MS; Eldeeb, HM; Mobark, MA; Mohammed, HA
Author Full Name Al-Omar, Mohsen S.; Eldeeb, Hussain M.; Mobark, Mugahid A.; Mohammed, Hamdoon A.
Title Antimicrobial activity and histopathological safety evidence of Ochradenus baccatus Delile: A medicinally important plant growing in Saudi Arabia
Source PHARMACOGNOSY RESEARCH
Language English
Document Type Article
Author Keywords Antimicrobial activity; histopathology; kidney function; lipid profile; liver function; Ochradenus baccatus
Keywords Plus ESSENTIAL OIL; EXTRACTS; CONSTITUENTS
Abstract Background: The growing climatic condition affects plant constituents and biological activities. Ochradenus baccatus (Taily Weed) from Resedaceae family is a perennial shrub that is widely used in folk medicine in the Middle East. Aim: From the viewpoint that O. baccatus is regularly used in folk medicine, this study was designed to evaluate the antimicrobial activity and investigate the effect of O. baccatus on the biochemical and histopathological parameters of liver and kidney in experimental animals. Methods: The O. baccatus extracts were obtained by hot continuous extraction method. Agar diffusion and minimal inhibitory concentration assays were used for the antimicrobial activity. O. baccatus total extracts at doses of 100 mg/kg and 50 mg/kg were given to the first and second groups of rates, respectively, whereas the third and fourth groups received the vehicle olive oil and saline, respectively. The liver and kidney functions, as well as lipid profile and glucose levels, were measured by spectrophotometric technique on obtained blood samples. The liver and kidney tissues were evaluated for histopathological effect. Results: Ethanol and ethyl acetate extracts have similarly and potentially inhibited the bacterial micro-organisms, whereas Candida albicans was inhibited by n-hexane extract. O. baccatus total extract showed no significant effects on the kidney and liver functions (P > 0.05). However, it significantly reduced triglyceride level (P = 0.04). The histopathological investigation of liver and kidney tissues revealed no significant differences compared to control animals. Conclusion: The medicinally important plant, O. baccatus, growing in Saudi Arabia showed no significant toxic effects on the livers and kidneys. Moreover, it demonstrated a potential antimicrobial activity besides a significant reduction in serum triglycerides in rats. These findings are in consistent with other reported results suggesting no environmental effects on the safety of this plant.
Author Address [Al-Omar, Mohsen S.; Mohammed, Hamdoon A.] Qassim Univ, Coll Pharm, Dept Med Chem & Pharmacognosy, Buraydah 51452, Saudi Arabia; [Eldeeb, Hussain M.] Qassim Univ, Coll Pharm, Dept Pharmacol, Buraydah 51452, Saudi Arabia; [Mobark, Mugahid A.] Qassim Univ, Coll Pharm, Dept Pharm Practice, Buraydah 51452, Saudi Arabia; [Al-Omar, Mohsen S.] JUST, Coll Pharm, Dept Med Chem & Pharmacognosy, Amman, Jordan; [Eldeeb, Hussain M.] Al Azhar Univ, Dept Med Biochem, Fac Med, Assiut, Egypt; [Mohammed, Hamdoon A.] Al Azhar Univ, Fac Pharm, Dept Pharmacognosy, Cairo 11371, Egypt; [Mobark, Mugahid A.] Univ Kordofan, Dept Pathol, Fac Med, Al Ubayyid, Sudan
Reprint Address Mohammed, HA (corresponding author), Qassim Univ, Coll Pharm, Dept Med Chem & Pharmacognosy, Buraydah 51452, Saudi Arabia.
E-mail Address ham.mohammed@qu.edu.sa
Publisher WOLTERS KLUWER MEDKNOW PUBLICATIONS
Publisher City MUMBAI
Publisher Address WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S NO 1498A-2 VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
ISSN 0974-8490
29-Character Source Abbreviation PHARMACOGN RES
ISO Source Abbreviation Pharmacogn. Res.
Publication Date APR-JUN
Year Published 2020
Volume 12
Issue 2
Beginning Page 131
Ending Page 136
Digital Object Identifier (DOI) 10.4103/pr.pr_103_19
Page Count 6
Web of Science Category Pharmacology & Pharmacy
Subject Category Pharmacology & Pharmacy
Document Delivery Number LT0YL
Unique Article Identifier WOS:000536802200007
Plants associated with this reference

LEGAL NOTICES — This website is protected by Copyright © The University of Sussex, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022. The eHALOPH database is protected by Database Right and Copyright © The University of Sussex and other contributors, 2006, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022. This database is based on an earlier work by James Aronson.
THIS WEBSITE AND THIS DATABASE ARE PROVIDED ON AN "AS IS" BASIS, AND YOU USE THEM AND RELY ON THEM AT YOUR OWN RISK.

Contact email: halophytes@sussex.ac.uk
Credits – Tim Flowers, Joaquim Santos, Moritz Jahns, Brian Warburton, Peter Reed