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Authors Lopez, D; Cherigo, L; de Sedas, A; Spadafora, C; Martinez-Luis, S
Author Full Name Lopez, Dioxelis; Cherigo, Lilia; de Sedas, Alejandro; Spadafora, Carmenza; Martinez-Luis, Sergio
Title Evaluation of antiparasitic, anticancer, antimicrobial and hypoglycemic properties of organic extracts from Panamanian mangrove plants
Source ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
Language English
Document Type Article
Author Keywords Mangrove plants; Anticancer activity; Antibacterial activity; Antiparasitic activity; Alpha-glucosidase inhibition
Keywords Plus ALPHA-GLUCOSIDASE; INHIBITORY-ACTIVITIES; RHIZOPHORA-MANGLE; NATURAL-PRODUCTS; ANTIOXIDANT; FUNGI
Abstract Objective: To investigate 33 organic extracts of mangrove plants for: antiparasitic, anticancer, and antibacterial activities, as well as their ability to inhibit the activity of the alpha -glucosidase enzyme. Methods: Leaves from all different plant mangrove species located in five mangrove zones of the Pacific coast of Panama were collected according to standard procedures. Qualitative phytochemical analysis of the organic extracts was performed by thin layer chromatography. The antiparasitic activity against Plasmodium falciparum, Trypanosoma cruzi and Leishmania donovani, toxicity against Artemia salina, anticancer activity in MCF-7 cell line, and antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa of all organic extract were investigated according protocols stablished in our institution. Finally, the ability to inhibit the enzymatic activity of alpha -glucosidase was evaluated by monitoring the hydrolysis of p-nitrophenyl alpha -D-glucopyranoside. Results: Thirty-three different samples belonging to nine different species of vascular plants with seeds of true mangroves were collected. Triterpenoids, phenolics, and tannins were the main groups of compounds found in the sampled mangroves. Saponins, quinones, and coumarins were found in less than 50% of the samples. Laguncularia racemosa showed moderate activity against Plasmodium falciparum. None of the extracts presented anticancer activity. Rhizophora mangle exhibited potent activity against Staphylococcus aureus and Bacillus subtilis [(90.41 +/- 7.33)% and (96.02 +/- 6.14)% of inhibition]; Avicennia germinans and Conocarpus erectus had activity against Escherichia coli [(71.17 +/- 6.15)% and (60.60 +/- 5.13)% of inhibition, respectively]. About 60% of the mangroves showed alpha -glucosidase inhibitory activity. In particular, extracts from Laguncularia racemosa, Pelliciera rhizophorae, Conocarpus erectus, Mora oleifera, and Tabebuia palustris species showed. - glucosidase inhibitory potential, with IC50 values of (29.45 +/- 0.29), (20.60 +/- 0.70), (730.06 +/- 3.74), (25.59 +/- 0.37), and (853.39 +/- 5.30) mu g/mL, respectively. Conclusions: Panamanian mangroves are mainly a promising potential source of hypoglycemic compounds, specifically alpha - glucosidase inhibitors. These results highlight the therapeutic virtues of extracts from American mangrove plants.
Author Address [Lopez, Dioxelis; de Sedas, Alejandro; Martinez-Luis, Sergio] Ctr Biodiversidad & Descubrimiento Drogas, Inst Invest Cient, Edificio 219,Apartado 0843-01103, Panama City, Panama; [Lopez, Dioxelis; de Sedas, Alejandro; Spadafora, Carmenza; Martinez-Luis, Sergio] INDICASAT AIP, Serv Alta Tecnol, Edificio 219,Apartado 0843-01103, Panama City, Panama; [Lopez, Dioxelis; de Sedas, Alejandro] Acharya Nagarjuna Univ, Dept Biotechnol, Nagarjuna Nagar 522510, Guntur, India; [Cherigo, Lilia] Univ Panama, Fac Ciencias Exactas & Tecnol, Dept Quim Organ, POB 3366, Panama City, Panama; [Spadafora, Carmenza] Ctr Biol Celular & Mol Enfermedades, Inst Invest Cient, Edificio 219,Apartado 0843-01103, Panama City, Panama
Reprint Address Martinez-Luis, S (reprint author), Ctr Biodiversidad & Descubrimiento Drogas, Inst Invest Cient, Edificio 219,Apartado 0843-01103, Panama City, Panama.; Martinez-Luis, S (reprint author), INDICASAT AIP, Serv Alta Tecnol, Edificio 219,Apartado 0843-01103, Panama City, Panama.
E-mail Address dlopez@indicasat.org.pa; smartinez@indicasat.org.pa
Funding Agency and Grant Number National Secretariat for Science and Technology of Panama (SENACYT) [FID14-063]; National Secretariat of Science, Technology and Innovation (SENACYT) [270-2011-154]; National Research System of SENACYT [SNI1472016, SNI1452016]
Funding Text We would like to thank the government of Panama (Ministerio de Ambiente) for granting permission to make the collections of mangrove samples. This work was partially supported by the National Secretariat for Science and Technology of Panama (SENACYT) [grant number FID14-063]. Dioxelis Lopez was supported by funds from the National Secretariat of Science, Technology and Innovation (SENACYT) doctoral [grant number 270-2011-154]. Lilia Cherigo and Sergio Martinez-Luis were supported by funds from the National Research System of SENACYT [SNI1472016 and SNI1452016, respectively]. Finally, to Alberto E. Morales (Department of Anthropology at the University of California, Irvine) for the spelling and grammar revision.
Times Cited 8
Total Times Cited Count (WoS, BCI, and CSCD) 8
Publisher WOLTERS KLUWER MEDKNOW PUBLICATIONS
Publisher City MUMBAI
Publisher Address WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S NO 1498A-2 VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
ISSN 1995-7645
29-Character Source Abbreviation ASIAN PAC J TROP MED
ISO Source Abbreviation Asian Pac. J. Trop. Med.
Publication Date JAN
Year Published 2018
Volume 11
Issue 1
Beginning Page 32
Ending Page 39
Digital Object Identifier (DOI) 10.4103/1995-7645.223531
Page Count 8
Web of Science Category Public, Environmental & Occupational Health; Tropical Medicine
Subject Category Public, Environmental & Occupational Health; Tropical Medicine
Document Delivery Number FW7MH
Unique Article Identifier WOS:000425507300005
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