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Publication Type J
Authors Ben Hsouna, A., S. Dhibi, W. Dhifi, R. Ben Saad, F. Brini, N. Hfaidh, J. Almeida and W. Mnif
Title Lobularia maritima leave extract, a nutraceutical agent with antioxidant activity, protects against CCl4-induced liver injury in mice
Source Drug and Chemical Toxicology
Author Keywords Lobularia maritima phenolic compounds carbon tetrachloride hepatoprotective oxidative stress histopathological analysis carbon-tetrachloride oxidative stress hepatoprotective activity lipid-peroxidation phenolic-acids essential oil damage hepatotoxicity flavonoids mechanism
Abstract Lobularia maritima (Alyssum maritimum, Brassicaceae), commonly known as sweet alyssum, is an annual ornamental halophyte widely spread along the Tunisian seashore. Lobularia maritima leaf ethanol extract was tested in an experimental model of hepatotoxicity induced by carbon tetrachloride (CCl4). L. maritima extract was found to possess in vitro antioxidant activity by scavenging the DPPH radical (IC50= 45 mu g/mL), reducing/chelating iron ions and inhibiting liver lipid peroxidation induced by FeSO4. The levels of total phenolics and flavonoids were 175 +/- 2.66 mg GAE/g, and 35 +/- 2.88 mg QE/g respectively. Moreover, HPLC analysis revealed six compounds, namely gallic, salicylic, ellagic and ferulic acids as well as catechin and quercetin. A mice model of acute liver injury was successfully established after a single intraperitoneal injection of CCl4, as evidenced by histological analysis, Masson trichrome and Sirius red staining. Compared with the CCl4 intoxicated group, the L. maritima treatment resulted to reduce the liver serum marker enzymes, lipid peroxidation and increased the activities of antioxidant enzymes with further amelioration in the oxidative stress. The present findings discover the therapeutic potentials of L. maritima empowered with promising natural leads for the treatment of oxidative stress associated health disorders by attenuating free radicals, inhibiting lipid peroxidation, and upregulating the tissue-specific antioxidant enzymes.
Author Address [Ben Hsouna, Anis] Fac Sci Gafsa, Dept Life Sci, Gafsa, Tunisia. [Ben Hsouna, Anis; Ben Saad, Rania; Brini, Faical] Ctr Biotechnol Sfax, Biotechnol & Plant Improvement Lab, Sfax, Tunisia. [Dhibi, Sabah; Hfaidh, Najla] Univ Gafsa, Fac Sci, Lab Anim Ecophysiol, Gafsa, Tunisia. [Dhifi, Wissal] Univ Manouba, Lab Physiopathol Alimentat & Biomol, BiotechPole Sidi Thabet, PAB,LR17ES03,Higher Inst Biotechnol Sidi Thabet, Ariana, Tunisia. [Guedes da Silva Almeida, Jackson Roberto] Fed Univ Vale Sao Francisco, Ctr Studies & Res Med Plants, Petrolina, Brazil. [Mnif, Wissem] Univ Bisha, Fac Sci & Arts Balgarn, Dept Chem, Bisha, Saudi Arabia. [Mnif, Wissem] Univ Manouba, Lab Biotechnol & Valorisat BiogeoRessources, BVBGR, LR11ES31,Higher Inst Biotechnol Sidi Thabet,Biote, Ariana 2020, Tunisia. Mnif, W (reprint author), Univ Manouba, Lab Biotechnol & Valorisat BiogeoRessources, BVBGR, LR11ES31,Higher Inst Biotechnol Sidi Thabet,Biote, Ariana 2020, Tunisia. w_mnif@yahoo.fr
ISSN 0148-0545
ISBN 0148-0545
29-Character Source Abbreviation Drug Chem. Toxicol.
Digital Object Identifier (DOI) 10.1080/01480545.2020.1742730
Unique Article Identifier WOS:000523704500001

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