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Publication Type J
Authors Castaneda-Loaiza, V., C. Placines, M. J. Rodrigues, C. G. Pereira, G. Zengin, N. R. Neng, J. M. F. Nogueira and L. Custodio
Title In vitro enzyme inhibitory and anti-oxidant properties, cytotoxicity and chemical composition of the halophyte Malcolmia littorea (L.) R.Br. (Brassicaceae)
Source Natural Product Research
Author Keywords Phytochemicals tyrosinase inhibitors cholinesterase inhibitors salt tolerant plants
Abstract This work reports for the first time the in vitro anti-oxidant (towards DPPH, ABTS, copper and iron), enzymatic inhibitory (on AChE, BuChE, alpha-glucosidase, alpha-amylase and tyrosinase), cytotoxicity (towards HepG2 and HEK 293 cells), and metabolomics (by HPLC-MS) of extracts from organs of Malcolmia littorea (L.) R.Br. Extracts were constituted mainly by phenolic acids and flavonoids, and main compounds were salicylic acid and luteolin-7-O-glucoside. Samples showed reduced radical scavenging and metal chelating capacity, and only the methanol extracts reduced iron. The root's ethanol and methanol extracts, and the aerial organ's ethanol extract exhibited the highest AChE inhibition. The root's ethanol extract displayed dual anti-cholinesterase activity. Samples showed a low capacity to inhibit alpha-amylase, but a high alpha-glucosidase inhibition was obtained with the root's and flower's ethanol extracts, and flower's methanol extract. Overall, samples displayed a high inhibition against tyrosinase, reduced HepG2 cellular viability and were less toxic towards HEK 293 cells.
Author Address [Castaneda-Loaiza, Viana; Placines, Chloe; Rodrigues, Maria Joao; Pereira, Catarina G.; Custodio, Luisa] Univ Algarve, Fac Sci & Technol, Ctr Marine Sci, Faro, Portugal. [Zengin, Gokhan] Selcuk Univ, Sci Fac, Dept Biol, Konya, Turkey. [Neng, Nuno R.; Nogueira, Jose M. F.] Univ Lisbon, Dept Chem & Biochem, Fac Sci, Ctr Chem & Biochem, Lisbon, Portugal. Custodio, L (reprint author), Univ Algarve, Fac Sci & Technol, Ctr Marine Sci, Faro, Portugal. lcustodio@ualg.pt
ISSN 1478-6419
ISBN 1478-6419
29-Character Source Abbreviation Nat. Prod. Res.
Digital Object Identifier (DOI) 10.1080/14786419.2020.1719484
Unique Article Identifier WOS:000512555100001

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