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Publication Type J
Authors Bahramsoltani, R., M. H. Farzaei, A. Iranpanah, M. Hajimahmoudi, Z. Pourjabar, M. Daglia, C. Santarcangelo, K. Rashidi, S. M. Nabavi and R. Rahimi
Title Phytochemical and toxicological evaluation of Tamarix stricta Boiss
Source Drug and Chemical Toxicology
Author Keywords Tamarix tamarisk halophyte phytochemical polyphenol flavonoid wound-healing activities antioxidant l. tamaricaceae phenolics health leaves plants acid
Abstract The genus Tamarix includes several plant species well-known for their medicinal properties since ancient times. Tamarix stricta Boiss is a plant native to Iran which has not been previously investigated regarding its phytochemical and biological properties. This study assessed phytochemical and toxicological aspects of T. stricta. The plant was collected from Kerman province of Iran and after authentication by botanist, it was extracted with 70% ethanol. Total phenolic compounds, total flavonoids, and antioxidant properties were measured using spectrophometric methods. Quercetin content of the extract was measured after complete acid hydrolysis with high-performance liquid chromatography. The phytochemical profile of the extract was provided using liquid chromatography-mass spectrometry method. Acute toxicity study with a single intragastric dose of 5000 mg/kg of the extract and sub-chronic toxicity using 50, 100, and 250 mg/kg of the extract was assessed in Wistar rats. Phytochemical analysis showed that polyphenols constitute the major components of the extract. Also, the extract contained 1.552 +/- 0.35 mg/g of quercetin. Biochemical, hematological, and histological evaluations showed no sign of toxicity in animals. Our experiment showed that T. stricta is a rich source of polyphenols and can be a safe medicinal plant. Further pharmacological evaluations are recommended to assess the therapeutic properties of this plant.
Author Address [Bahramsoltani, Roodabeh; Rahimi, Roja] Univ Tehran Med Sci, Sch Persian Med, Dept Tradit Pharm, Tehran 1417653761, Iran. [Bahramsoltani, Roodabeh; Rahimi, Roja] USERN, PhytoPharmacol Interest Grp PPIG, Tehran, Iran. [Farzaei, Mohammad Hosein; Iranpanah, Amin] Kermanshah Univ Med Sci, Pharmaceut Sci Res Ctr, Hlth Inst, Kermanshah, Iran. [Farzaei, Mohammad Hosein] Kermanshah Univ Med Sci, Med Biol Res Ctr, Kermanshah, Iran. [Iranpanah, Amin] Kermanshah Univ Med Sci, Student Res Comm, Kermanshah, Iran. [Hajimahmoudi, Mannan; Pourjabar, Zeinab] Univ Tehran Med Sci, Fac Pharm, Drug & Food Control Dept, Tehran, Iran. [Daglia, Maria; Santarcangelo, Cristina] Univ Naples Federico II, Dept Pharm, Naples, Italy. [Rashidi, Khodabakhsh] Kermanshah Univ Med Sci, Res Ctr Oils & Fats, Kermanshah, Iran. [Nabavi, Seyed Mohammad] Baghyatollah Univ Med Sci, Appl Biotechnol Res Ctr, Tehran, Iran. [Daglia, Maria] Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang, Jiangsu, Peoples R China. Rahimi, R (reprint author), Univ Tehran Med Sci, Sch Persian Med, Dept Tradit Pharm, Tehran 1417653761, Iran.; Rahimi, R (reprint author), USERN, PhytoPharmacol Interest Grp PPIG, Tehran, Iran. rojarahimi@gmail.com
ISSN 0148-0545
ISBN 0148-0545
29-Character Source Abbreviation Drug Chem. Toxicol.
Digital Object Identifier (DOI) 10.1080/01480545.2019.1680687
Unique Article Identifier WOS:000491968800001

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