Research Fellow in Replication Stress and Cancer Ref 2796
School/department: School of Life Sciences / Genome Damage and Stability Centre
Hours: Full time or part time hours considered up to a maximum of 1.0 FTE. Requests for flexible working options will be considered (subject to business need)
Contract: Fixed term for 3 years initially
Salary: Starting at £33,797 and rising to £40,322 per annum, pro rata (if applicable)
Placed on: 26 November 2019
Closing date: 03 January 2020. Applications must be received by midnight of the closing date.
Expected interview date: W/C 13 January 2020
Expected start date: ASAP
The School of Life Sciences is at the forefront of research in the biological sciences in the UK, coming in the top 10 in the REF 2014.
Based in the School of Life Sciences, the Genome Damage and Stability Centre (http://www.sussex.ac.uk/gdsc/index), is an internationally renowned Institute carrying out research on the response of cells to DNA damage, genome instability and its relationship to disease. We provide a stimulating and supportive environment and our expertise covers a range of experimental systems. An overview of research interests of the Rass lab can be found at https://www.sussex.ac.uk/lifesci/rasslab/.
A postdoctoral fellowship, funded by The Academy of Medical Sciences, is available immediately to study effector-level inhibition of the DNA replication stress response as a strategy to selectively kill cancer cells by stress-overload.
Replication stress is a hallmark of cancer that can drive tumourigenesis, but also represents a potential Achilles’ heel of the disease. The available project uses a breast cancer model to investigate the molecular mechanisms of the cellular replication stress response, and how inhibiting its effector proteins may be exploited to eliminate cancer cells.
Candidates should have a strong background in genome stability with evidence of independence and productivity (first authorship publication). This post is funded for 3 years initially. Applicants must have experience in human cell culture and CRISPR-Cas9-mediated genome editing. Experience in the molecular and cytological analysis of DNA damage and repair and/or replication is a plus.
Applications should be accompanied by a full CV, a statement of research interests and aspirations (up to a total of 4 pages), and the names of two academic referees. Informal enquiries are welcome and should be sent to Prof. Ulrich Rass at U.W.Rass@sussex.ac.uk.
The School is committed to equality and valuing diversity, and currently holds an Athena SWAN Silver Award. Applications are particularly welcomed from women and black and minority ethnic candidates, who are under-represented in academic posts in Science, Technology, Engineering, Medicine and Mathematics (STEMM) at Sussex. The School of Life Sciences welcomes applications to academic posts from candidates who wish to work part-time or as job-sharers.
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