Research Fellow Ref 9792

School/department: Genome Damage and Stability Centre, School of Life Sciences  
Hours: full time, core hours 10am-4pm. Requests for flexible working options will be considered (subject to business need).
Contract: fixed term until 13 March 2025
Reference: 9792
Salary: starting at £35,333 to £42,155 per annum
Placed on:  20 September 2022.
Closing date: 07 October 2022. Applications must be received by midnight of the closing date.
Expected Interview date: TBC
Expected start date: 01 December 2022


Job description

The School of Life Sciences at the University of Sussex is at the forefront of research in the UK. In the recent Research Excellence Framework assessment (REF 2021), 100% of our Impact cases in Biological Sciences and Chemistry were rated as world-leading or internationally excellent. The School has received substantial recent University investment and is embarking on an exciting and extensive, muti-million pound refurbishment and improvement project.

Based in the School of Life Sciences, the Genome Damage and Stability Centre  (http://www.sussex.ac.uk/gdsc/), is an internationally renowned Institute carrying out research on the response of cells to DNA damage, genome instability and its relationship to disease. We provide a stimulating and supportive environment and our expertise covers a range of experimental systems.

We wish to appoint a postdoctoral fellow, funded by a Catalyst Award from  Breast Cancer Now, starting Dec 1st 2022 to analyse a new signalling pathway that synergises with Cdk4/6 and could be exploited therapeutically in triple negative breast cancer cells.

Cdk4/6 inhibitors such as Pfizer’s Palbociclib have been successfully employed to treat ER positive breast cancer. However, the most aggressive types of breast cancer do not respond well to Palbociclib and even cancer types that do respond often develop resistance to the treatment. This necessitates new combinatorial strategies to treat this pathway more effectively. This project will investigate a novel pathway that acts in parallel to Cdk4/6 in early G1 phase to uncover basic mechanisms and design therapeutic strategies for triple negative breast cancer patients.

Candidates must have experience in human cell culture, CRISPR-Cas9-mediated genome editing and be familiar with basic data science approaches (Python, Matlab) and the analysis of high throughput imaging data. They should have a strong background in cell cycle control with evidence of independence and productivity (first authorship publication). This post is funded for 3 years.

The School of Life Sciences is committed to increasing the diversity of its staff and providing an inclusive working environment. The School currently holds an Athena SWAN Silver Award, has developed a Race Equity Action Plan and hosts an active Equality, Diversity and Inclusion working group.

Applications are particularly welcomed from Black and minority ethnic candidates, and women, trans and non-binary candidates, who are under-represented in the School of Life Sciences.

Applications to posts from candidates who wish to work part-time or as job-sharers are welcome.

The University offers various schemes to provide real benefits to parents, these can be found at Family Friendly Policies

The University is committed to equality and valuing diversity, and applications are particularly welcomed from women and black and minority ethnic candidates, who are under-represented in academic posts in Science, Technology, Engineering, Medicine and Mathematics (STEMM) at Sussex.

Please note that this position may be subject to ATAS clearance if you require visa sponsorship.

The University of Sussex values the diversity of its staff and students and we welcome applicants from all backgrounds.

You can find out more about our values and our EDI Strategy,  Inclusive Sussex, on our webpages.

Download job description and person specification Ref 9792 [PDF 195.83KB]

The University requires that work undertaken for the University is performed from the UK. 

Visa Sponsorship Queries:

This role has been assigned an eligible SOC code and meets the salary requirements for Skilled Worker Sponsorship if full time. Please consult our Skilled Worker Visa information page  for further information about Visa Sponsorship.


How to apply

Download our academic application form [DOC 199.50KB] and Personal Details and Equal Opportunities Form [DOC 119.50KB] and fill in all sections.

Email your completed application, and personal details and equal opportunities form, to lifescirecruitment@sussex.ac.uk

You should attach your application form and all documents to the email in PDF format (we are unable to accept applications as google.docs or .pages) and use the format job reference number / job title / your name in the subject line.

Applications should be accompanied by a full CV, a statement of research interests and aspirations (up to a total of 4 pages), and the names of two academic referees. Informal enquiries are welcome and should be sent to Dr. Helfrid Hochegger at hh65@sussex.ac.uk before applying

You can also send your application by post to Human Resources Division, Sussex House, University of Sussex, Falmer, Brighton, BN1 9RH.


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