Research Fellow - Exploring Novel Roles of Greatwall Kinase in Healthy and Cancer Cells Ref 7966
School/department: Genome Damage and Stability Centre, School of Life Sciences
Hours: Full time and part time considered up to a maximum of 1FTE
Requests for flexible working options will be considered (subject to business need).
Full time, core hours 10am-4pm.
Contract: fixed term until 31 May 2025
Reference: 7966
Salary: starting at £34,304 to £40,927 per annum, pro rata if part time
Placed on: 28 March 2022
Closing date: 3 May 2022 . Applications must be received by midnight of the closing date.
Expected interview date: to be confirmed
Expected start date: 1 June 2022
Job description
The School of Life Sciences is at the forefront of research in the biological sciences in the UK, coming in the top 10 in the REF 2014.
Based in the School of Life Sciences, the Genome Damage and Stability Centre (http://www.sussex.ac.uk/gdsc/), is an internationally renowned Institute carrying out research on the response of cells to DNA damage, genome instability and its relationship to disease. We provide a stimulating and supportive environment and our expertise covers a range of experimental systems.
- A postdoctoral fellowship, funded by a Program Award from CRUK, is available starting June 1st 2022 to investigate mechanisms of mitotic entry control in cancer cells.
- The mitotic entry network ensures that cells switch between interphase and mitosis in a timely and coordinated manner by activating Cdk1 at the right time and place. This control system constitutes a classical cell cycle switch that is tightly regulated and integrates signals from DNA replication, repair, cell growth and metabolism. We have recently made progress in understanding how kinase activation and phosphatase inactivation are coordinated and how Cyclin A and B contribute to this transition (Rata et al. 2018, Current Biology; Lemmens et al. 2018 Mol. Cell; Hegarat et al. 2020 EMBOJ, Stiff et al. Cell Reports, 2020).
- The aim of this project will be to expand this line of research and investigate the role of various components of this switch system with a focus on how cancer cells have adapted mitotic entry control to cope with elevated levels of replication stress.
- This project will be supported by available small molecule inhibitors, genetically engineered cell lines and will employ an interdisciplinary approach involving cell biology, high-throughput and high-resolution microscopy of fixed and live cells, genetic, proteomic and bioinformatic analysis.
Please contact Helfrid Hochegger, hh65@sussex.ac.uk for informal enquiries.
The University is committed to equality and valuing diversity, and applications are particularly welcomed from women and black and minority ethnic candidates, who are under-represented in academic posts in Science, Technology, Engineering, Medicine and Mathematics (STEMM) at Sussex.
Please note that this position may be subject to ATAS clearance if you require visa sponsorship.
The University of Sussex values the diversity of its staff and students and we welcome applicants from all backgrounds.
You can find out more about our values and our EDI Strategy, Inclusive Sussex, on our webpages.
Download job description and person specification Ref 7966 [PDF 203.87KB]
The University requires that work undertaken for the University is performed from the UK.
Visa Sponsorship Queries:
This role has been assigned an eligible SOC code however to meet the minimum salary requirement this is dependent on the salary you are offered and/or whether you are eligible for tradeable points. If you require visa sponsorship from the University of Sussex to undertake this role please consult our Skilled Worker Visa information page for further information. If you want further advice on sponsorship eligibility please contact HRCompliance@sussex.ac.uk
How to apply
Download our academic application form [DOC 199.50KB] and Personal Details and Equal Opportunities Form [DOC 119.50KB] and fill in all sections.
Email your completed application, and personal details and equal opportunities form, to lifescirecruitment@sussex.ac.uk
You should attach your application form and all documents to the email in PDF format (we are unable to accept applications as google.docs or .pages) and use the format job reference number / job title / your name in the subject line.
You can also send your application by post to Human Resources Division, Sussex House, University of Sussex, Falmer, Brighton, BN1 9RH.