Research Fellow in Cancer Cell Signalling Ref 6092
School/department: School of Life Sciences
Hours: Full time or part time up to a maximum of 1FTE
Contract: Fixed term for 1 year (with an option to extend it for another year)
Salary: starting at £33,797 to 40,322 (Grade 7 point 3)
Placed on: 3 June 2021
Closing date: 31 August 2021 Applications must be received by midnight of the closing date.
Expected start date: 1 October 2021
Project: ‘Elucidating the molecular signalling pathways of LMTK3 in cancer’
A post-doctoral position is available in the laboratory of Georgios Giamas to elucidate the involvement of LMTK3 in cancer progression.
The oncogenic role of Lemur tyrosine kinase 3 (LMTK3) has been well established the last years, as supported by mechanistic and translational data in different tumour types and settings.
Recently, we solved the crystal structure of the LMTK3 kinase domain, determined its consensus motif and revealed that LMTK3 is a heat shock protein 90 (HSP90) client protein, requiring HSP90 for folding and stability.
Moreover, we identified a novel, potent LMTK3 small-molecule inhibitor with a good selectivity profile exhibiting potent anticancer activity in a wide panel of human cancer cell lines (NCI-60 panel), and in in vivo breast cancer mouse models .
Since LMTK3 has been proposed as a potential new therapeutic target in breast cancer and considering its involvement in additional tumours, there is urgent pressing need to further decipher the signalling pathways that LMTK3 is implicated in as well as the regulation of LMTK3 by different proteins.
Amongst the goals of this project are to:
- identify novel upstream regulators of LMTK3,
- identify novel phosphorylation substrates of LMTK3,
- perform (co)/crystallography studies of LMTK3 alone and in combination with different drugs.
For these aims, a variety of biochemical, structural and molecular/cellular biology techniques will be employed and therefore extensive expertise in these fields is required. The predominant cancer types that will be used as models for this study will be breast and brain tumours (in particular glioblastomas).
We are an active research group and provide a stimulating and supportive research environment combining a variety of in vitro and in vivo models / tools. An overview of research within the Giamas lab can be found at: http://www.sussex.ac.uk/lifesci/giamaslab/
The School of Life Sciences is at the forefront of research in the biological sciences in the UK, coming in the top 10 in the REF 2014.
Please contact Prof Georgios Giamas E-mail: firstname.lastname@example.org; (Tel: +44 1273 873163) for informal enquiries.
The University is committed to equality and valuing diversity, and applications are particularly welcomed from women and black and minority ethnic candidates, who are under-represented in academic posts in Science, Technology, Engineering, Medicine and Mathematics (STEMM) at Sussex.
Visa Sponsorship Queries:
If you require visa sponsorship from the University of Sussex to undertake this role, you can find further information on our Visa page or contact HRCompliance@sussex.ac.uk to discuss your personal circumstances and whether you meet the criteria
Please note that this position may be subject to ATAS clearance if you require visa sponsorship.
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