Research Fellow in the genomic engineering to discover drive genes in Breast Cancer Ref 0475
School/department: School of Life Sciences
Hours: full time or part time hours considered up to a maximum of 1.0 FTE. Requests for flexible working options will be considered (subject to business need)
Contract: fixed term 1.5 years
Salary: starting at £32,548 and rising to £38,833 per annum
Placed on: 26 November 2018
Closing date: 2 January 2019. Applications must be received by midnight of the closing date.
Expected start date: January 2019
The School of Life Sciences is at the forefront of research in the biological sciences in the UK, coming in the top 10 in the REF 2014.
We wish to appoint a Research Fellow in Breast Cancer genomic engineering.
The RNA-guided Clustered Regularly Interspaced Short Palindrome Repeats linked with the nuclease CAS9 (CRISPR/CAS9), can modify the genomes to pre-defined regions offering the possibility to introduce loss-of-function mutations through introduction of indels or deletions. When these modifications are applied to important genetic elements they will ultimately inform about specific gene regulation and function.
Genome scale CRISPR-based approaches can modify cancer genomes to multiple sites and have been successfully used to discover new cancer gene drivers.
The post-holder will be entitled to perform CRISPR/CAS9 genome scale approaches to delineate crucial coding and noncoding RNAs that drive breast cancers. The work will be carried out by using selected breast cancer cell lines and patient derived organoids.
It is required that the applicant is familiar with CRISPR Cas9, RNA molecular biology techniques including RNA immunoprecipitation, Co-IP, ChIP, and lentiviral transduction.
The post-holder will work closely with Dr Leandro Castellano at University of Sussex.
For informal enquiries, please contact Dr Leandro Castellano by email (L.Castellano@sussex.ac.uk)
How to apply
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