Postdoctoral Research Fellow – DNA Replication stress and links to cancer Ref 0684

School/department: School of Life Sciences
Hours: Full time position - part time/job share hours considered. Requests for flexible working options will also be considered (subject to business need). 
Contract: Fixed term for 2 years initially 
Reference: 0684 
Salary: Starting at £33,199 and rising to £39,609 per annum, pro rata
Placed on: 29 January 2019 
Closing date: 28 February 2019. Applications must be received by midnight of the closing date 
Expected start date: As soon as possible


Job description

A postdoctoral fellowship is available immediately to study the cellular responses to DNA replication stress.

Replication stress is a hallmark of cancer and drives chromosome instability. The available project uses a recently developed breast cancer progression model to investigate the molecular mechanisms of DNA replication fork recovery, replication completion and chromosome stability, and how inhibiting effectors of these processes may be exploited to kill cancer cells by stress-overload.

Candidates should have a strong background in genome stability with evidence of independence and productivity (first authorship publication). This post is funded for 2 years initially.

Applicants must have experience in human cell culture, CRISPR-Cas9-mediated genome editing, and molecular and cytological analyses of DNA repair and/or replication.

The successful candidate will join the Genome Damage and Stability Centre (http://www.sussex.ac.uk/gdsc/), an internationally renowned institute within the School of Life Sciences, carrying out research on cellular responses to DNA damage and their impact on genome instability and disease.

We provide a stimulating and supportive research environment and our expertise covers a wide range of experimental systems. An overview of research interests of the Rass lab can be found at https://www.sussex.ac.uk/lifesci/rasslab/.

The School of Life Sciences is at the forefront of research in the biological sciences in the UK, coming in the top 10 in the REF 2014.

The School is committed to equality and valuing diversity, and currently holds an Athena SWAN Silver Award.

Applications are particularly welcomed from women and black and minority ethnic candidates, who are under-represented in academic posts in Science, Technology, Engineering, Medicine and Mathematics (STEMM) at Sussex.

The School of Life Sciences welcomes applications to academic posts from candidates who wish to work part-time or as job-sharers.

The University offers various schemes to provide real benefits to parents, these can be found at Family Friendly Policies

Download job description and person specification Ref 0684 [PDF 132.90KB]


How to apply

Download our academic post application form [DOC 301.50KB] and personal details and equal opportunities form [DOC 162.50KB] and fill in all sections.

Application forms should be accompanied by a full CV, a statement of research interests and aspirations (up to a total of 4 pages), and the names of two academic referees. Informal enquiries are welcome and should be sent to Prof. Ulrich Rass at U.W.Rass@sussex.ac.uk.

Email your completed application, and personal details and equal opportunities form, to lifescirecruitment@sussex.ac.uk 

You should attach your application form and all documents to the email (don't use a web-based upload/weblink service) and use the format job reference number / job title / your name in the subject line.

You can also send your application by post to Human Resources Division, Sussex House, University of Sussex, Falmer, Brighton, BN1 9RH.

Download our terms and conditions summary for Research Faculty Terms and Conditions [DOC 36.00KB]


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