Postdoctoral Research Fellow Ref 3200
School/department: School of Life Sciences
Hours: Full timeor part time hours considered up to a maximum of 1.0 FTE. Requests for flexible working options will be considered (subject to business need).
Contract: fixed term for 2 years.
Salary: starting at £33,797 to £40,322 per annum
Placed on: 10 February 2020
Closing date: 10 March 2020. Applications must be received by midnight of the closing date.
Expected start date: Flexible.
The School of Life Sciences is at the forefront of research in the biological sciences in the UK, coming in the top 10 in the REF 2014.
Applicants are invited to apply for a AMS-funded postdoctoral position to study the hypothesis that nuclear compartmentalization drives the specificity in the DNA repair outcome by identifying factors that are specifically recruited to distinct nuclear environments upon DNA damage by quantitative proteomics. The aim of this project is to induce DNA breaks at specific locations in human and mouse genomes and evaluate how these are sensed and repaired over time and to determine whether DNA repair efficiency and robustness is related to specific 3D genomic locations of DNA lesions. For visualization and mapping of breaks high end microscopy and NGS approaches will be used. Expertise in any of the above will be positively considered but not absolutely requited.
Based in the School of Life Sciences, the Genome Damage and Stability Centre (http://www.sussex.ac.uk/gdsc/index), is an internationally renowned Institute carrying out research on the response of cells to DNA damage, genome instability and its relationship to disease. We provide a stimulating and supportive environment and our expertise covers a range of experimental systems.
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