Introduction to Metabolism and Pharmacology
Module code: C7135
15 credits in spring semester
Teaching method: Seminar, Lecture
Assessment modes: Coursework, Unseen examination
This module aims to introduce you to the general principles of metabolism and pharmacology. The initial lectures cover ATP, substrate-level phosphorylation, Chemiosmosis and oxidative phosphorylation, glycolysis, and the the Krebs cycle. This is complemented by lectures covering glycogen, nucleotide and lipid metabolism, introducing metabolic flux with exercise as an example. Anti-metabolites, anti-cancer drugs and G protein agonist and antagonists will be discussed as examples of therapeutic intervention. The pharmacology aspects of the module will cover how drugs act at receptors, ion channels and specific enzymes, their molecular targets and the underlying cellular mechanisms of action. It will cover methods and measurement in pharmacology and the absorption and distribution of drugs, their elimination and pharmacokinetics.
Module learning outcomes
- Demonstrate an understanding the major pathways of glucose metabolism and the general principles of metabolism including: metabolic regulation and energy coupling; energy coupling involving adenosine triphosphate (ATP); phosphate group transfer; substrate level phosphorylation (in glycolysis) and oxidative phosphorylation.
- Demonstrate an understanding of: the Chemiosmotic theory; glycogen metabolism and its regulation; lipid metabolism and its regulation, including acute and long term exercise.
- Demonstrate an understanding of nucleotide metabolism and anti-cancer drugs.
- Demonstrate an understanding of: the general principles by which drugs act and measurement methods used in pharmacology; Phase 1 and Phase 2 drug metabolism and pharmacokinetics; the cellular mechanisms of drug action with reference to specific classes of drugs in routine use.