Life Sciences

Neuronal Plasticity and Gene Regulation

Module code: C1121
Level 6
15 credits in spring teaching
Teaching method: Lecture
Assessment modes: Coursework, Unseen examination

This module will consider how cellular and molecular mechanisms interact in the regulation of neuronal plasticity, the ability of the nervous system to adapt its structural-functional organisation to new situations emerging from changes in intrinsic and extrinsic inputs. During the module particular emphasis will be placed on mechanisms underlying the acquisition, processing and storage of information by the nervous system. You will also discuss recently discovered phenomena such as epigenetic regulation and natural antisense transcripts (NATs) in the context of their importance for the regulation of neural functions.

Pre-requisite

Biochemistry students taking this module will not be able to select the formal pre-requisite, however the core module, Principles of Neuroscience, will be fine in place of NTT for these students

Module learning outcomes

  • Demonstrate a knowledge and systematic understanding of the role of molecular and macromolecular structures in synaptic plasticity and memory
  • Appreciate the role of epigenetic mechanisms (DNA methylation, histone modifications, non-coding RNAs) in normal and pathological conditions in the brain
  • Demonstrate the ability to review and critically evaluate current research on the role of molecular mechanisms in specific types of neuronal plasticity