Selected publications

Article

De Vos, Kurt J and Hafezparast, Majid (2017) Neurobiology of axonal transport defects in motor neuron diseases: opportunities for translational research? Neurobiology of Disease, 105. pp. 283-299. ISSN 0969-9961

Chiang, Shih-Chieh, Meagher, Martin, Kassouf, Nick, Hafezparast, Majid, McKinnon, Peter J, Haywood, Rachel and El-Khamisy, Sherif F (2017) Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical–induced DNA damage. Science Advances, 3 (4). e1602506. ISSN 2375-2548

Scoto, Mariacristina, Rossor, Alexander M, Harms, Matthew B, Cirak, Sebahattin, Calissano, Mattia, Robb, Stephanie, Manzur, Adnan Y, Martínez Arroyo, Amaia, Rodriguez Sanz, Aida, Mansour, Sahar, Fallon, Penny, Hadjikoumi, Irene, Klein, Andrea, Yang, Michele, De Visser, Marianne, Overweg-Plandsoen, W C G Truus, Baas, Frank, Taylor, J Paul, Benatar, Michael, Connolly, Anne M, Al-Lozi, Muhammad T, Nixon, John, de Goede, Christian G E L, Foley, A Reghan, Mcwilliam, Catherine, Pitt, Matthew, Sewry, Caroline, Phadke, Rahul, Hafezparast, Majid, Chong, W K Kling, Mercuri, Eugenio, Baloh, Robert H, Reilly, Mary M and Muntoni, Francesco (2015) Novel mutations expand the clinical spectrum of DYNC1H1-associated spinal muscular atrophy. Neurology, 84 (7). pp. 668-679. ISSN 1526-632X

Carroll, Jean, Page, Tristan K W, Chiang, Shih-Chieh, Kalmar, Bernadett, Bode, David, Greensmith, Linda, Mckinnon, Peter J, Thorpe, Julian R, Hafezparast, Majid and El-Khamisy, Sherif F (2015) Expression of a pathogenic mutation of SOD1 sensitizes aprataxin-deficient cells and mice to oxidative stress and triggers hallmarks of premature ageing. Human Molecular Genetics, 24 (3). pp. 828-40. ISSN 1460-2083

Garrett, Caroline A, Barri, Muruj, Kuta, Anna, Soura, Violetta, Deng, Wenhan, Fisher, Elizabeth M C, Schiavo, Giampietro and Hafezparast, Majid (2014) DYNC1H1 mutation alters transport kinetics and ERK1/2-cFos signalling in a mouse model of distal spinal muscular atrophy. Brain, 137 (7). pp. 1883-1893. ISSN 1460-2156

Rulten, Stuart L, Rotheray, Amy, Green, Ryan L, Grundy, Gabrielle J, Moore, Duncan A Q, Gómez-Herreros, Fernando, Hafezparast, Majid and Caldecott, Keith W (2014) PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage. Nucleic Acids Research, 42 (1). pp. 307-314. ISSN 1362-4962

Schiavo, Giampietro, Greensmith, Linda, Hafezparast, Majid and Fisher, Elizabeth M C (2013) Cytoplasmic dynein heavy chain: the servant of many masters. Trends in neurosciences, 36 (11). pp. 641-651. ISSN 1878-108X

Oates, Emily C, Rossor, Alexander M, Hafezparast, Majid, Gonzalez, Michael, Speziani, Fiorella, Macarthur, Daniel G, Lek, Monkol, Cottenie, Ellen, Scoto, Mariacristina, Foley, A Reghan, Hurles, Matthew, Houlden, Henty, Greensmith, Linda, Auer-Grumbach, Michaela, Pieber, Thomas R, Strom, Tim M, Schule, Rebecca, Herrmann, David N, Sowden, Janet E, Ascadi, Gyula, Menezes, MP, Clarke, Nigel F, Zuchner, Stephan, Muntoni, Francesco, North, Kathryn N and Reilly, Mary M (2013) Mutations in BICD2 cause dominant congenital spinal muscular atrophy and hereditary spastic paraplegia. American Journal of Human Genetics, 92 (6). pp. 965-973. ISSN 0002-9297

Crossley, Laurie, Garrett, Caroline A, Hafezparast, Majid and Madzvamuse, Anotida (2012) From the cell membrane to the nucleus: unearthing transport mechanisms for Dynein. Bulletin of Mathematical Biology, 74 (9). pp. 2032-2061. ISSN 1522-9602

Rosse, Carine, Boeckeler, Katrina, Linch, Mark, Radtke, Simone, Frith, David, Barnouin, Karin, Morsi, Ali Sayed, Hafezparast, Majid, Howell, Michael and Parker, Peter J (2012) Binding of dynein intermediate chain 2 to paxillin controls focal adhesion dynamics and migration. Journal of Cell Science, 125 (16). pp. 3733-3738. ISSN 0021-9533

Acevedo-Arozena, Abraham, Kalmar, Bernadett, Essa, Shafa, Ricketts, Thomas, Joyce, Peter, Kent, Rosie, Rowe, Claire, Parker, Andy, Gray, Anna, Hafezparast, Majid, Thorpe, Julian R, Greensmith, Linda and Fisher, Elizabeth M C (2011) A comprehensive assessment of the SOD1G93A low-copy transgenic mouse, which models human amyotrophic lateral sclerosis. Disease Models and Mechanisms, 4 (5). pp. 686-700. ISSN 1754-8403

Banks, Gareth T, Haas, Matilda A, Line, Samantha, Shepherd, Hazel L, AlQatari, Mona, Stewart, Sammy, Rishal, Ida, Philpott, Amelia, Hafezparast, Majid and et al, (2011) Behavioral and other phenotypes in a cytoplasmic Dynein light intermediate chain 1 mutant mouse. Journal of Neuroscience, 31 (14). pp. 5483-5494. ISSN 0270-6474

Eschbach, Judith, Fergani, Anissa, Oudart, Hugues, Robin, Jean-Patrice, Rene, Frédérique, de Aguilar, Jose-Luis Gonzalez, Larment, Yves, Zoll, Joffrey, Hafezparast, Majid, Schwalenstocker, Birgit, Loeffler, Jean-Philippe, Ludolph, Albert C and Dupuis, Luc (2011) Mutations in cytoplasmic dynein lead to a Huntington's disease-like defect in energy metabolism of brown and white adipose tissues. BBA - Molecular Basis of Disease, 1812 (1). pp. 59-69. ISSN 0925-4439

Deng, Wenhan, Garrett, Caroline, Dombert, Benjamin, Soura, Violetta, Banks, Gareth, Fisher, Elizabeth M C, van der Brug, Marcel P and Hafezparast, Majid (2010) Neurodegenerative mutation in cytoplasmic dynein alters its organization and dynein-dynactin and dynein-kinesin interactions. Journal of Biological Chemistry, 285 (51). pp. 39922-39934. ISSN 0021-9258

Kuta, Anna, Deng, Wenhan, Morsi el Kadi, Ali, Banks, Gareth T, Hafezparast, Majid, Pfister, K Kevin and Fisher, Elizabeth M C (2010) Mouse cytoplasmic dynein intermediate chains: identification of new isoforms, alternative splicing and tissue distribution of transcripts. PLoS ONE, 5 (7). ISSN 1932-6203

Morsi el Kadi, Ali, Bros-Facer, Virginie, Deng, Wenhan, Philpott, Amelia, Stoddart, Eleanor, Banks, Gareth, Jackson, Graham S, Fisher, Elizabeth M C, Duchen, Michael R, Greensmith, Linda, Moore, Anthony L and Hafezparast, Majid (2010) The Legs at odd angles (Loa) mutation in cytoplasmic dynein ameliorates mitochondrial function in SOD1G93A mouse model for motor neuron disease. Journal of Biological Chemistry, 285 (24). pp. 18627-18639. ISSN 1083-351X

Ateh, D D, Hussain, I K, Mustafa, A H, Price, K M, Gulati, R, Nickols, C D, Bird, M M, Greensmith, L, Hafezparast, M, Fisher, E M C, Baker, C S and Martin, J E (2008) Dynein-dynactin complex subunits are differentially localized in brain and spinal cord, with selective involvement in pathological features of neurodegenerative disease. Neuropathology and Applied Neurobiology, 34 (1). pp. 88-94. ISSN 0305-1846

El-Kadi, Ali Morsi, Soura, Violetta and Hafezparast, Majid (2007) Defective axonal transport in motor neuron disease. Journal of Neuroscience Research, 85 (12). pp. 2557-2566. ISSN 0360-4012

Myers, Kennth R, Lo, Kevin W-H, Lye, R John, Kogoy, John M, Soura, Violetta, Hafezparast, Majid and Pfister, K Kevin (2007) Intermediate chain subunit as a probe for cytoplasmic dynein function: biochemical analyses and live cell imaging in PC12 cells. Journal of Neuroscience Research, 85 (12). pp. 2640-2647. ISSN 0360-4012

Bowen, Samantha, Ateh, Davidson D, Deinhardt, Katrin, Bird, Margeret M, Price, Karen M, Baker, Cathy S, Robson, Joanna C, Swash, Michael, Shamsuddin, Wassim, Kawar, Shalini, El-Tawil, Tariq, Roos, Jesper, Hoyle, Andrew, Nickols, Carole D, Knowles, Charles H, Pullen, Anthony H, Luthert, Phillip J, Weller, Roy O, Hafezparast, Majid, Franklin, Robin J M, Revesz, Tamas, King, Rosalind H M, Berninghausen, Otto, Fisher, Elizabeth M C, Schiavo, Giampietro and Martin, Joanne E (2007) The phagocytic capacity of neurones. European Journal of Neuroscience, 25 (10). pp. 2947-55. ISSN 0953-816X

Ateh, D D, Hussain, I, Mustafa, A, Price, K M, Nickols, C D, Bird, M M, Greensmith, L, Schiavo, G, Hafezparast, M, Fisher, E M C, Baker, C S and Martin, J E (2006) Normal subcellular distribution of dynein-dynactin complex subunits and disturbances in neurodegenerative disease. Neuropathology and Applied Neurobiology, 32 (2). pp. 234-235. ISSN 0305-1846

Ateh, D, Hussain, I, Mustafa, A, Price, K M, Nickols, C D, Bird, M M, Greensmith, L, Schiavo, G, Hafezparast, M, Fisher, E M C, Baker, C S and Martin, J E (2006) Subcellular functional specificity of dynein-dynactin complex subunits - normal distribution and disturbances in neurodegenerative disease. Journal of Pathology, 208 (S1). 23A-23A. ISSN 0022-3417

Achilli, Francesca, Boyle, Shelagh, Kieran, Dairin, Chia, Ruth, Hafezparast, Majid, Martin, Joanne E, Schiavo, Giampietro, Greensmith, Linda, Bickmore, Wendy and Fisher, Elizabeth M C (2005) The SOD1 transgene in the G93A mouse model of amyotrophic lateral sclerosis lies on distal mouse chromosome 12. Amyotrophic Lateral Sclerosis, 6 (2). pp. 111-114. ISSN 1748-2968

Kieran, Dairin, Hafezparast, Majid, Bohnert, Stephanie, Dick, James R T, Martin, Joanne, Schiavo, Giampietro, Fisher, Elizabeth M C and Greensmith, Linda (2005) A mutation in dynein rescues axonal transport defects and extends the lifespan of ALS mice. Journal of Cell Biology, 169 (4). pp. 561-7. ISSN 0021-9525

Hafezparast, Majid, Brandner, Sebastian, Linehan, Jackie, Martin, Joanne E, Collinge, John and Fisher, Elizabeth M C (2004) Prion disease incubation time is not affected in mice heterozygous for a dynein mutation. Biochemical and Biophysical Research Communications, 326 (1). pp. 18-22. ISSN 0006-291X

Hafezparast, Majid, Ahmad-Annuar, Azlina, Hummerich, Holger, Shah, Paresh, Ford, Melisa, Baker, Cathy, Bowen, Sam, Martin, Joanne E and Fisher, Elizabeth M C (2003) Paradigms for the identification of new genes in motor neuron degeneration. Amyotrophic Lateral Sclerosis, 4 (4). pp. 249-57. ISSN 1748-2968

Ahmad-Annuar, Azlina, Shah, Paresh, Hafezparast, Majid, Hummerich, Holger, Witherden, Abi S, Morrison, Karen E, Shaw, Pamela J, Kirby, Janine, Warner, Thomas T, Crosby, Andrew, Proukakis, Christos, Wilkinson, Philip, Orrell, Richard W, Bradley, Lloyd, Martin, Joanne E and Fisher, Elizabeth M C (2003) No association with common Caucasian genotypes in exons 8, 13 and 14 of the human cytoplasmic dynein heavy chain gene (DNCHC1) and familial motor neuron disorders. Amyotrophic Lateral Sclerosis, 4 (3). pp. 150-157. ISSN 1748-2968

Hafezparast, Majid, Klocke, Rainer, Ruhrberg, Christiana, Marquardt, Andreas, Ahmad-Annuar, Azlina, Bowen, Samantha, Lalli, Giovanna, Witherden, Abi S, Hummerich, Holger, Nicholson, Sharon, Morgan, P Jeffrey, Oozageer, Ravi, Priestley, John V, Averill, Sharon, King, Von R, Ball, Simon, Peters, Jo, Toda, Takashi, Yamamoto, Ayumu, Hiraoka, Yasushi, Augustin, Martin, Korthaus, Dirk, Wattler, Sigrid, Wabnitz, Philipp, Dickneite, Carmen, Lampel, Stefan, Boehme, Florian, Peraus, Gisela, Popp, Andreas, Rudelius, Martina, Schlegel, Juergen, Fuchs, Helmut, de Angelis, Martin Hrabe, Schiavo, Giampietro, Shima, David T, Russ, Andreas P, Stumm, Gabriele, Martin, Joanne E and Fisher, Elizabeth M C (2003) Mutations in Dynein Link Motor Neuron Degeneration to Defects in Retrograde Transport. Science, 300 (5620). pp. 808-812. ISSN 0036-8075

Hafezparast, Majid, Ahmad-Annuar, Azlina, Wood, Nicholas W, Tabrizi, Sarah J and Fisher, Elizabeth M C (2002) Mouse models for neurological disease. Lancet Neurology, 1 (4). pp. 215-224. ISSN 1474-4422

Hafezparast, Majid, Ball, Simon, Nicholson, Sharon J, Witherden, Abi, Arac, Demet, Broadway, Neil, Saggerson, David, Cooper, Edwin, Naase, Mahmoud, Gokhale, Stephen, Quant, Patti, Lascelles, Carol, Nickols, Carole, Baker, Cathy S, Peters, Josephine, Martin, Joanne E and Fisher, Elizabeth M C (2002) A new mouse mutant, skijumper. Mammalian Genome, 13 (7). pp. 359-364. ISSN 0938-8990

Hafezparast, Majid (2002) Fusion protein delays Wallerian degeneration. Trends in Molecular Medicine, 8 (3). pp. 106-107. ISSN 1471-4914

Witherden, Abi S, Hafezparast, Majid, Nicholson, Sharon J, Ahmad-Annuar, Azlina, Bermingham, Nessan, Arac, Demet, Rankin, Joanna, Iravani, Marjan, Ball, Simon, Peters, Jo, Martin, Joanne E, Huntley, Derek, Hummerich, Holger, Sergot, Marek and Fisher, Elizabeth M C (2002) An integrated genetic, radiation hybrid, physical and transcription map of a region of distal mouse chromosome 12, including an imprinted locus and the `Legs at odd angles¿ (Loa) mutation. Gene, 283 (1-2). pp. 71-82. ISSN 0378-1119

Hafezparast, Majid (2001) NF1 mice: smaller brains but no tumours. Trends in Molecular Medicine, 7 (7). p. 285. ISSN 1471-4914

Rogers, Derek C, Peters, Jo, Martin, Joanne E, Ball, Simon, Nicholson, Sharon J, Witherden, Abi S, Hafezparast, Majid, Latcham, Judy, Robinson, Tracey L, Quilter, Charlotte A and Fisher, Elizabeth M C (2001) SHIRPA, a protocol for behavioral assessment: validation for longitudinal study of neurological dysfunction in mice. Neuroscience Letters, 306 (1-2). pp. 89-92. ISSN 0304-3940

Banks, Gareth T, Haas, Matilda A, Line, Samantha, Shepherd, Hazel L, Al Qatari, Mona, Stewart, Sammy, Rishal, Ida, Philpott, Amelia, Kalmar, Bernadett, Kuta, Anna, Groves, Michael, Parkinson, Nicholas, Acevedo-Arozena, Abraham, Brandner, Sebastian, Banerman, David, Greensmith, Linda, Hafezparast, Majid, Koltzenburg, Martin, Deacon, Robert, Fainzilber, Mike and Fisher, Elizabeth M C (2001) Behavioral and Other Phenotypes in a Cytoplasmic Dynein Light Intermediate Chain 1 Mutant Mouse. Journal of Neuroscience, 31 (14). pp. 5483-5494. ISSN 0270-6474

Nicholson, S J, Witherden, A S, Hafezparast, M, Martin, J E and Fisher, E M (2000) Mice, the motor system, and human motor neuron pathology. Mammalian Genome, 11 (12). pp. 1041-1052. ISSN 09388990

Hafezparast, Majid (2000) Caspases and neurodegenerative diseases. Molecular Medicine Today, 6 (9). p. 338. ISSN 1357-4310

Beck, J A, Lloyd, S, Hafezparast, M, Lennon-Piece, M, Eppig, J T, Festing, M F and Fisher, E M (2000) Genealogies of mouse inbred strains. Nature Genetics, 24 (1). pp. 23-25. ISSN 1061-4036

Hafezparast, Majid, Witherden, Abi, Nicholson, Sharon, Bermingham, Nessan, Mackin, James, ten Asbroek, Anneloor, Ball, Simon, Peters, Josephine, Baas, Frank, Martin, Joanne E and Fisher, Elizabeth M C (1999) The kinesin light chain gene: its mapping and exclusion in mouse and human forms of inherited motor neuron degeneration. Neuroscience Letters, 273 (1). pp. 49-52. ISSN 0304-3940

Conference or Workshop Item

Philpott, A, Bros, V, Flenniken, A, Schiavo, G, Fisher, E, Greensmith, L and Hafezparast, M (2009) Cellular and molecular characterization of abnormal rear leg (Arl) - a new mouse strain with a point mutation in cytoplasmic dynein. In: 19th Gentics-Society-Mammalian-Genetics-and-Development Workshop, Univ Coll London, Inst Child Hlth, London, ENGLAND.

Soura, V, Morsi el Kadi, A, Kuta, A, Garrett, C, Deng, W, Fisher, E M C, Schiavo, G and Hafezparast, M (2009) The Legs at odd angles (Loa) mutation in cytoplasmic dynein impairs TrkB-BDNF endocytic transport in motor neurons. In: Gordon Research Conference on Neurotrophic Factors, Salve Regina University, Newport, RI.