Selected publications

Article

Sansook, Supojjanee, Ocasio, Cory A, Day, Iain J, Tizzard, Graham J, Coles, Simon, Fedorov, Oleg, Bennett, James, Elkins, Jon and Spencer, John (2017) Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety. Organic and Biomolecular Chemistry (40). ISSN 1477-0520

Khan, Raysa, Felix, Robert, Kemmitt, Paul D, Coles, Simon J, Tizzard, Graham J and Spencer, John (2017) N1-arylation of 1,4-benzodiazepine-2-ones with diaryliodonium salts. Synlett. ISSN 0936-5214

Boonseng, Sarote, Roffe, Gavin W, Targema, Msugh, Spencer, John and Cox, Hazel (2017) Rationalization of the mechanism of in situ Pd(0) formation for cross-coupling reactions from novel unsymmetrical pincer palladacycles using DFT calculations. Journal of Organometallic Chemistry, 845. pp. 71-81. ISSN 0022-328X

Lineham, Ella, Spencer, John and Morley, Simon (2017) Dual abrogation of Mnk and mTOR; a novel therapeutic approach for the treatment of aggressive cancers. Future Medicinal Chemistry, 9 (13). ISSN 1756-8919

Ocasio, Tony, Sansook, Supojjanee, Jones, Alice Rhiannon, Roberts, Justin, Scott, Thomas, Tsoureas, Nikolaos, Coxhead, Peter, Guille, Matthew, Tizzard, Graham J, Coles, Simon J, Hochegger, Helfrid, Bradner, James E and Spencer, John (2017) Pojamide: An HDAC3-selective ferrocene analogue with remarkably enhanced redox-triggered ferrocenium activity in cells. Organometallics, 36 (17). pp. 3276-3283. ISSN 0276-7333

Khan, Raysa, Marsh, Graham, Felix, Robert, Kemmitt, Paul D, Baud, Matthias G J, Ciulli, Alessio and Spencer, John (2017) Gram scale laboratory synthesis of TC AC 28, a high affinity BET bromodomain ligand. ACS Omega, 2 (8). pp. 4328-4332. ISSN 2470-1343

Khan, Raysa, Boonseng, Sarote, Kemmitt, Paul, Felix, Robert, Coles, Simon J, Tizzard, Graham J, Williams, Gareth, Simmonds, Olivia, Harvey, Jessica-Lily, Atack, John, Cox, Hazel and Spencer, John (2017) Combining Sanford arylations on benzodiazepines with the nuisance effect. Advanced Synthesis and Catalysis, 359 (18). pp. 3261-3269. ISSN 1615-4150

Licona, Cynthia, Spaety, Marie-Elodie, Capuozzo, Antonella, Ali, Moussa, Santamaria, Rita, Armant, Olivier, Delalande, Francois, Van Dorsselaer, Alain, Cianferani, Sarah, Spencer, John, Pfeffer, Michel, Mellitzer, Georg and Gaiddon, Christian (2017) A ruthenium anticancer compound interacts with histones and impacts differently on epigenetic and death pathways compared to cisplatin. Oncotarget, 8 (2). pp. 2568-2584. ISSN 1949-2553

Ansell, Melvyn B, Navarro, Oscar and Spencer, John (2017) Transition metal catalyzed element–element′ additions to alkynes. Coordination Chemistry Reviews, 336. pp. 54-77. ISSN 0010-8545

Tuo, Wei, Leleu-Chavain, Natascha, Spencer, John, Sansook, Supojjanee, Millet, Regis and Chavatte, Philippe (2017) Therapeutic potential of fatty acid amide hydrolase, monoacylglycerol lipase, and N-acylethanolamine acid amidase inhibitors. Journal of Medicinal Chemistry, 60 (1). pp. 4-46. ISSN 0022-2623

Ansell, Melvyn B, Kostakis, George E, Braunschweig, Holger, Navarro Fernandez, Oscar and Spencer, John (2016) Synthesis of functionalized hydrazines: facile homogeneous (n-heterocyclic carbene)-palladium(0)-catalyzed diboration and silaboration of azobenzenes. Advanced Synthesis and Catalysis, 358 (23). pp. 3765-3769. ISSN 1615-4150

Ocasio, Cory A, Rajasekaran, Mohan B, Walker, Sarah, Le Grand, Darren, Spencer, John, Pearl, Frances M G, Ward, Simon E, Savic, Velibor, Pearl, Laurence H, Hochegger, Helfrid and Oliver, Antony W (2016) A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct. Oncotarget, 7 (44). 71182 -71197. ISSN 1949-2553

Boonseng, Sarote, Roffe, Gavin W, Jones, Rhiannon N, Tizzard, Graham J, Coles, Simon J, Spencer, John and Cox, Hazel (2016) The trans influence in unsymmetrical pincer palladacycles: an experimental and computational study. Inorganics, 4 (25). pp. 1-14. ISSN 2304-6740

Librizzi, Mariangela, Spencer, John and Luparello, Claudio (2016) Biological effect of a hybrid anticancer agent based on kinase and histone deacetylase inhibitors on triple-negative (MDA-MB231) breast cancer cells. International Journal of Molecular Sciences, 17 (8). p. 1235. ISSN 1422-0067

Close, Adam J, Kemmitt, Paul, Roe, S Mark and Spencer, John (2016) Regioselective routes to orthogonally-substituted aromatic MIDA boronates. Organic and Biomolecular Chemistry, 14 (28). pp. 6751-6756. ISSN 1477-0520

Close, Adam J, Jones, Rhiannon N, Ocasio, Cory A, Kemmitt, Paul, Roe, S Mark and Spencer, John (2016) Elaboration of tetra-orthogonally-substituted aromatic scaffolds towards novel EGFR-kinase inhibitors. Organic and Biomolecular Chemistry, 14. pp. 8246-8252. ISSN 1477-0520

Bauer, Matthias R, Jones, Rhiannon N, Baud, Matthias G J, Wilcken, Rainer, Boeckler, Frank M, Fersht, Alan, Joerger, Andreas C and Spencer, John (2016) Harnessing fluorine-sulfur contacts and multipolar interactions for the design of p53 mutant Y220C rescue drugs. ACS Chemical Biology, 11 (8). pp. 2265-2274. ISSN 1554-8929

Roffe, Gavin, Tizzard, Graham J, Coles, Simon J, Cox, Hazel and Spencer, John (2016) Synthesis of unsymmetrical NCN′ and PCN pincer palladacycles and their catalytic evaluation compared with a related SCN pincer palladacycle. Organic Chemistry Frontiers, 3 (8). pp. 957-965. ISSN 2052-4110

Tuschl, Karin, Meyer, Esther, Valdivia, Leonardo E, Zhao, Ningning, Dadswell, Chris, Abdul-Sada, Alaa, Hung, Christina Y, Simpson, Michael A, Chong, W K, Jacques, Thomas S, Woltjer, Randy L, Eaton, Simon, Gregory, Allison, Sanford, Lynn, Kara, Eleanna, Houlden, Henry, Cuno, Stephan M, Prokisch, Holger, Valletta, Lorella, Tiranti, Valeria, Younis, Rasha, Maher, Eamonn R, Spencer, John, Straatman-Iwanowska, Ania, Gissen, Paul, Selim, Laila A M, Pintos-Morell, Guillem, Coroleu-Lletget, Wifredo, Mohammad, Shekeeb S, Yoganathan, Sangeetha, Dale, Russell C, Thomas, Maya, Rihel, Jason, Bodamer, Olaf A, Enns, Caroline A, Hayflick, Susan J, Clayton, Peter T, Mills, Philippa B, Kurian, Manju A and Wilson, Stephen W (2016) Mutations in SLC39A14 disrupt manganese homeostasis and cause childhood-onset parkinsonism–dystonia. Nature Communications, 7. p. 11601. ISSN 2041-1723

Spencer, John (2016) [Review] Stefan Bräse (2015) Privileged scaffolds in medicinal chemistry: design, synthesis, evaluation. ChemMedChem, 11 (10). p. 1107. ISSN 1860-7179

Roffe, Gavin W, Boonseng, Sarote, Baltus, Christine B, Coles, Simon J, Day, Iain, Jones, Rhiannon N, Press, Neil J, Ruiz, Mario, Tizzard, Graham J, Cox, Hazel and Spencer, John (2016) A synthetic, catalytic and theoretical investigation of an unsymmetrical SCN pincer palladacycle. Royal Society Open Science, 3 (4). p. 150656. ISSN 2054-5703

Ansell, Melvyn B, Spencer, John and Navarro Fernandez, Oscar (2016) (N-heterocyclic carbene)2-Pd(0) catalyzed silaboration of internal and terminal alkynes: scope and mechanistic studies. ACS Catalysis, 6 (4). pp. 2192-2196. ISSN 2155-5435

Griffiths, Kieran, Dokorou, Vassiliki N, Spencer, John, Abdul-Sada, Alaa, Vargas, Alfredo and Kostakis, George E (2016) Isoskeletal Schiff base polynuclear coordination clusters: synthetic and theoretical aspects. CrystEngComm, 18 (5). pp. 704-713. ISSN 1466-8033

Khan, Raysa, Felix, Robert, Kemmitt, Paul D, Coles, Simon J, Day, Iain J, Tizzard, Graham J and Spencer, John (2016) Late stage C―H activation of a privileged scaffold; synthesis of a library of benzodiazepines. Advanced Synthesis and Catalysis, 358 (1). pp. 98-109. ISSN 1615-4150

Sansook, Supojjanee, Tuo, Wei, Lemaire, Lucas, Tourteau, Aurélien, Barczyk, Amélie, Dezitter, Xavier, Klupsch, Frédérique, Leleu-Chavain, Natascha, Tizzard, Graham J, Coles, Simon J, Millet, Régis and Spencer, John (2016) Synthesis of bioorganometallic nanomolar-potent CB2agonists containing a ferrocene unit. Organometallics, 35 (19). pp. 3361-3368. ISSN 0276-7333

Ansell, Melvyn B, Menezes da Silva, Vitor H, Heerdt, Gabriel, Braga, Ataualpa A C, Spencer, John and Navarro, Oscar (2016) An experimental and theoretical study into the facile, homogenous (N-Heterocyclic Carbene)2-Pd(0) catalyzed diboration of internal and terminal alkynes. Catalysis Science and Technology, 6. pp. 7461-7467. ISSN 2044-4753

Cox, Oakley B, Krojer, Tobias, Collins, Patrick, Monteiro, Octovia, Talon, Romain, Bradley, Anthony, Fedorov, Oleg, Amin, Jahangir, Marsden, Brian D, Spencer, John, von Delft, Frank and Brennan, Paul E (2016) A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain. Chemical Science, 7 (3). pp. 2322-2330. ISSN 2041-6520

Sgarlata, Carmelo, Oliveri, Valentina and Spencer, John (2015) A 8-hydroxyquinoline-cyclodextrin conjugate as an efficient chelating agent for cobalt(II) and nickel(II) in neutral aqueous solution. European Journal of Inorganic Chemistry, 2015 (36). pp. 5886-5891. ISSN 1434-1948

Owusu-Ware, Samuel K, Cherry, Anthony J, Baltus, Christine B, Spencer, John and Antonijevic, Milan D (2015) Thermal analysis of novel biphenylamide derivative. Journal of Thermal Analysis and Calorimetry, 121 (1). pp. 437-452. ISSN 1388-6150

Longo, Alessandra, Librizzi, Mariangela, Chuckowree, Irina S, Baltus, Christine B, Spencer, John and Luparello, Claudio (2015) Cytotoxicity of the urokinase-plasminogen activator inhibitor carbamimidothioic acid (4-boronophenyl) methyl ester hydrobromide (BC-11) on triple-negative MDA-MB231 breast cancer cells. Molecules, 20 (6). pp. 9879-9889. ISSN 1420-3049

Ansell, Melvyn B, Roberts, Debbie E, Cloke, F Geoffrey N, Navarro, Oscar and Spencer, John (2015) Synthesis of an (NHC)2Pd(SiMe3)2 (NHC = N-Heterocyclic Carbene) Complex. Catalytic, cis-Bis-Silylations of Internal Alkynes with Unactivated Disilanes. Angewandte Chemie International Edition, 54 (19). pp. 5578-5582. ISSN 1433-7851

Barbosa, Cintya, Corrêa, José R., Medeiros, Gisele A, Barreto, Gabrielle, Magalhães, Kelly G, de Oliveira, Aline L, Spencer, John, Rodrigues, Marcelo O and Neto, Brenno A D (2015) Carbon dots (C-dots) from cow manure with impressive subcellular selectivity tuned by simple chemical modification. Chemistry - A European Journal, 21 (13). 5055 -5060. ISSN 0947-6539

Boonseng, Sarote, Roffe, Gavin W, Spencer, John and Cox, Hazel (2015) The nature of the bonding in symmetrical pincer palladacycles. Dalton Transactions, 44. pp. 7570-7577. ISSN 1477-9226

Chang, Pishan, Zuckermann, Alexandra M E, Williams, Sophie, Close, Adam J, Cano-Jaimez, Marife, McEvoy, James P, Spencer, John, Walker, Matthew C and Williams, Robin S B (2015) Seizure control by derivatives of medium chain fatty acids associated with the ketogenic diet show novel branching-point structure for enhanced potency. Journal of Pharmacology and Experimental Therapeutics, 352 (1). pp. 43-52. ISSN 0022-3565

Burrows, Andrew D, Jurcic, Monika, Mahon, Mary F, Pierrat, Sandrine, Roffe, Gavin W, Windle, Henry J and Spencer, John (2015) Bismuth coordination networks containing deferiprone: synthesis, characterisation, stability and antibacterial activity. Dalton Trans., 44 (31). pp. 13814-13817. ISSN 1477-9226

Joerger, Andreas C, Bauer, Matthias R, Wilcken, Rainer, Baud, Matthias G J, Harbrecht, Hannes, Exner, Thomas E, Boeckler, Frank M, Spencer, John and Fersht, Alan R (2015) Exploiting transient protein states for the design of small-molecule stabilizers of mutant p53. Structure, 23 (12). pp. 2246-2255. ISSN 0969-2126

Spencer, John and Coaker, Hannah (2015) Highlights from SelectBio 2015: Academic Drug Discovery Conference, Cambridge, UK, 19–20 May 2015. Future Medicinal Chemistry, 7 (14). pp. 1839-1842. ISSN 1756-8919

Librizzi, Mariangela, Chiarelli, Roberto, Bosco, Liana, Sansook, Supojjanee, Gascon, Jose M, Spencer, John, Caradonna, Fabio and Luparello, Claudio (2015) The histone deacetylase inhibitor JAHA down-regulates pERK and global DNA methylation in MDA-MB231 breast cancer cells. Materials, 8 (10). pp. 7041-7047. ISSN 1996-1944

Lemaire, Lucas, Leleu-Chavain, Natascha, Tourteau, Aurélien, Abdul-Sada, Alaa, Spencer, John and Millet, Régis (2015) A rapid route for the preparation of pyrimido[5,4-d]- and pyrido[3,2-d]oxazole. Tetrahedron Letters, 56 (19). pp. 2448-2450. ISSN 0040-4039

Close, Adam J, Kemmitt, Paul, Emmerson, Matthew K and Spencer, John (2014) Microwave-mediated synthesis of N-methyliminodiacetic acid (MIDA) boronates. Tetrahedron, 70 (47). pp. 9125-9131. ISSN 0040-4020

Oliveri, Valentina, Attanasio, Francesco, Puglisi, Attanasio, Spencer, John, Sgarlata, Carmelo and Vecchio, Graziella (2014) Multifunctional 8-hydroxyquinoline-appended cyclodextrins as new inhibitors of metal-induced protein aggregation. Chemistry - A European Journal, 20 (29). pp. 8954-8964. ISSN 0947-6539

Patel, Hiren, Chuckowree, Irina, Coxhead, Peter, Guille, Matthew, Wang, Minghua, Zuckermann, Alexandra, Williams, Robin S B, Librizzi, Mariangela, Paranal, Ronald M, Bradner, James E and Spencer, John (2014) Synthesis of hybrid anticancer agents based on kinase and histone deacetylase inhibitors. MedChemComm, 5. pp. 1829-1833. ISSN 2040-2503

Palmer, Rex A, Spencer, John, Mendham, Andrew P, Chowdhry, Babur Z, Lisgarten, David R, Trost, Barry M, Cramer, Nico, Male, Louise and Coles, Simon J (2014) X-ray crystallographic structure of 3-(Propan-2-ylidene) benzofuran-2(3H)-one. Journal of Pharmaceutical Chemistry, 1 (3). p. 43. ISSN 2349-5731

Tizzard, Graham J, Coles, Simon J, Edwards, Mark, Oforbike Onyeabo, Romanus, Allen, Mark and Spencer, John (2013) Synthesis and solid-state characterisation of 4-substituted methylidene oxindoles. Chemistry Central Journal, 7. pp. 182-191. ISSN 1752-153X

Oliveri, Valentina, Puglisi, Antonino, Viale, Maurizio, Aiello, Cinzia, Sgarlata, Carmelo, Vecchio, Graziella, Clarke, James, Milton, John and Spencer, John (2013) New cyclodextrin-bearing 8-hydroxyquinoline ligands as multifunctional molecules. Chemistry - A European Journal, 19 (41). pp. 13946-13955. ISSN 0947-6539

Liu, Xiangrui, Wilcken, Rainer, Joerger, Andreas C, Chuckowree, Irina S, Amin, Jahangir, Spencer, John and Fersht, Alan R (2013) Small molecule induced reactivation of mutant p53 in cancer cells. Nucleic Acids Research, 41 (12). pp. 6034-6044. ISSN 0305-1048

Amin, Jahangir, Puglisi, Antonio, Clarke, James, Milton, John, Wang, Minghua, Paranal, Ronald M, Bradner, James E and Spencer, John (2013) A cyclodextrin-capped histone deacetylase inhibitor. Bioorganic and Medicinal Chemistry Letters, 23 (11). pp. 3346-3348. ISSN 0960-894X

Baltus, Christine B, Chuckowree, Irina S, Press, Neil J, Day, Iain J, Coles, Simon J, Tizzard, Graham J and Spencer, John (2013) Olefin cross-metathesis/Suzuki–Miyaura reactions on vinylphenylboronic acid pinacol esters. Tetrahedron Letters, 54 (10). pp. 1211-1217. ISSN 0040-4039

Burrows, Andrew D, Jurcic, Monika, Keenan, Luke L, Lane, Rebecca A, Mahon, Mary F, Warren, Mark R, Nowell, Harriot, Paradowski, Michael and Spencer, John (2013) Incorporation by coordination and release of the iron chelator drug deferiprone from zinc-based metal–organic frameworks. Chemical Communications, 49. pp. 11260-11262. ISSN 1359-7345

Amin, Jahangir, Chuckowree, Irina, Wang, Minghua, Tizzard, Graham J, Coles, Simon J and Spencer, John (2013) Synthesis of oxindole-based bioorganometallic kinase inhibitors incorporating one or more ferrocene groups. Organometallics, 32 (20). pp. 5818-5825. ISSN 0276-7333

Amin, Jahangir, Chuckowree, Irina, Tizzard, Graham J, Coles, Simon J, Wang, Minghua, Bingham, John P, Hartley, John A and Spencer, John (2013) Targeting epidermal growth factor receptor with ferrocene-based kinase inhibitors. Organometallics, 32 (2). pp. 509-513. ISSN 0276-7333

Baltus, Christine B, Press, Neil J, Antonijevic, Milan D, Tizzard, Graham J, Coles, Simon J and Spencer, John (2012) Synthesis of a biphenyl library for studies of hydrogen bonding in the solid state. Tetrahedron, 68 (45). pp. 9272-9277. ISSN 0040-4020

Clark, Rachel L, Clements, Carol J, Barrett, Michael P, Mackay, Simon P, Rathnam, Rajendra P, Owusu-Dapaah, George, Spencer, John and Huggan, Judith K (2012) Identification and development of the 1,4-benzodiazepin-2-one and quinazoline-2,4-dione scaffolds as submicromolar inhibitors of hat. Bioorganic & Medicinal Chemistry, 20 (20). pp. 6019-6033. ISSN 0968-0896

Chuckowree, Irina, Syed, Murtaza Ali, Getti, Giulia, Patel, Asha Parbhu, Garner, Hannah, Tizzard, Graham J, Coles, Simon J and Spencer, John (2012) Synthesis of a 1,3,5-benzotriazepine-2,4-dione based library. Tetrahedron Letters, 53 (28). pp. 3607-3611. ISSN 0040-4039

Librizzi, Mariangela, Longo, Alessandra, Chiarelli, Roberto, Amin, Jahanghir, Spencer, John and Luparello, Claudio (2012) Cytotoxic effects of Jay Amin hydroxamic acid (JAHA), a ferrocene-based class I histone deacetylase inhibitor, on triple-negative MDA-MB231 breast cancer cells. Chemical Research in Toxicology, 25 (11). pp. 2608-2611. ISSN 0893-228X

Puglisi, Antonino, Spencer, John, Oliveri, Valentina, Vecchio, Graziella, Kong, Xiaole, Clarke, James and Milton, John (2012) Synthesis, physicochemical properties and antioxidant activity of deferiprone-cyclodextrin conjugates and their iron(III) complexes. Dalton Transactions, 41 (10). pp. 2877-2883. ISSN 1477-9234

Spencer, John, Patel, Hiren, Deadman, John J, Palmer, Rex A, Male, Louise, Coles, Simon J, Uzoh, Oquaqa G and Price, Sarah L (2012) The unexpected but predictable tetrazole packing in flexible 1-benzyl-1H-tetrazole. CrystEngComm, 14. pp. 6441-6446. ISSN 1466-8033

Spencer, John, Amin, Jahangir, Coxhead, Peter, McGeehan, John, Richards, Christopher, Tizzard, Graham, Coles, Simon, Bingham, John, Hartley, John, Feng, Li, Meggers, Eric and Guille, Matthew (2011) Size does matter. Sterically demanding metallocene-substituted 3-methylidene-oxindoles exhibit poor kinase inhibitory action. Organometallics, 30 (11). pp. 3177-3181. ISSN 0276-7333

Spencer, John, Casini, Angela, Zava, Olivier, Rathnam, Rajendra P, Velhanda, Santosh K, Pfeffer, Michel, Callear, Samantha K, Hursthouse, Michael B and Dyson, Paul J (2009) Excellent correlation between cathepsin B inhibition and cytotoxicity for a series of palladacycles. Dalton transactions (48). pp. 10731-10735. ISSN 1477-9234

Spencer, John, Mendham, Andrew P, Kotha, Arun K, Richardson, Simon C W, Hillard, Elizabeth A, Jaouen, Gérard, Male, Louise and Hursthouse, Michael B (2009) Structural and biological investigation of ferrocene-substituted 3-methylidene-1,3-dihydro-2H-indol-2-ones. Dalton Transactions, 38 (6). pp. 918-921. ISSN 1477-9226

Spencer, John, Rathnam, Rajendra P, Motukuri, Mahesh, Kotha, Arun K, Richardson, Simon C W, Hazrati, Ali, Hartley, John A, Male, Louise and Hursthouse, Michael B (2009) Synthesis of a 1,4-benzodiazepine containing palladacycle with in vitro anticancer and cathepsin B activity. Dalton Transactions, 38 (22). pp. 4299-4303. ISSN 1477-9226

Dupont, Jairton, Consorti, Crestina S and Spencer, John (2005) The potential of palladacycles: more than just precatalysts. Chemical Reviews, 105 (6). pp. 2527-2572. ISSN 0009-2665

Book Section

Roffe, Gavin, Boonseng, Sarote, Cox, Hazel and Spencer, John (2017) Unsymmetrical Pincer palladacycles: synthesis and reactivity. In: Morales-Morales, David (ed.) Pincer compounds: chemistry and applications. Elsevier. (Accepted)