Research

The role of Wnt/β-catenin signalling in normal haematopoiesis and acute myeloid leukaemia (AML)

  • The molecular events leading to aberrant stabilisation and activitation of β-catenin in AML
  • The mechanisms regulating nuclear localisation of β-catenin in normal and malignant haematopoietic cells
  • The role of Wnt/β-catenin in normal myeloid development
  • The characterisation β-catenin protein interactions in blood cells
  • The development of novel therapeutic strategies which target aberrant Wnt/β-catenin signalling in haematological malignancies

Dr Morgan is keen to hear from enthusiastic, self-funded, students keen to pursue postgraduate studies within this field. Please consult university webpages for funded postgraduate opportunities.

Other research interests: Colorectal tumour cell survival mechanisms and chemoprevention

  • The mechanisms regulating expression of the stem cell marker LGR5
  • The function of LGR5 in normal colonic development and tumourigenesis
  • The pathological role of Wnt/β-catenin and EGF signalling in colorectal cancer

Collaborators

  • Prof Richard Darley, Dr Alex Tonks, Dr Neil Rodrigues - Cardiff University
  • Dr Steven Coles - University of Worcester
  • Dr Robert Ewing - University of Southampton
  • Prof Ann Williams, Dr Allison Blair - University of Bristol
  • Dr Alexander Greenhough - University of the West of England (UWE)
  • Dr Marian Waterman - University of California, Irvine
  • Dr Erika Mancini - University of Sussex
  • Dr Maria Teresa Esposito - University of Roehampton

Current Funding

  • Kay Kendall Leukaemia Fund (KKLF) Junior Fellowship
  • British Society for Haematology (BSH) Early Stage Research Start Up Grant
  • The Royal Society Research Grant

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Extracurricular

Dr Morgan is an advocate of stem cell donation and continues to work with Anthony Nolan and Marrow to promote awareness and registration onto the bone marrow register. Read more about his recent stem cell donation which reached national news: 

http://www.mirror.co.uk/news/uk-news/leukaemia-researcher-who-lost-brother-7940707

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