Work in the Adesakin Lab is aimed at understanding the molecular mechanisms that underline Alzheimer’s disease using our favourite model, the fruit fly, Drosophila. Although we have gained significant advances, and identified key molecules that play a role in Alzheimer’s disease, there still remains no cure for the disease.  Moreover, we still have a limited idea of the mechanism that ultimately results in neuronal cell death in AD. Our goal is to uncover potential pathways/proteins involved in disease progression in order to identify potential therapeutic targets. We do this by utilizing Drosophila models of Alzheimer’s disease to identify genetic interactions, which also encompasses using several molecular tools and several behavioural readouts to assess neuronal function.