Mark began his research career at the University of Nottingham, obtaining his EPSRC/GlaxoSmithKline funded PhD under the supervision of Professor Christopher J. Moody. After being awarded a JSPS Postdoctoral Fellowship for Foreign Researchers, Mark moved to the University of Tokyo to work on the development of organosuperbase catalysed reactions within the group of Professor Shu Kobayashi. Upon returning to the UK, he joined the group of Professor Julian Blagg at the Institute of Cancer Research, working towards the development of novel cancer therapeutics. In September 2015 Mark joined the group of Professor Simon Ward in the Sussex Drug Discovery Centre as a Research Fellow in Medicinal Chemistry.