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Brian Cox
Professor of Pharmaceutical Chemistry (Chemistry)
E:
T: +44 (0)1273 678329

Selected publications

Article

Porter, David W, Bradley, Michelle, Brown, Zarin, Charlton, Steven J, Cox, Brian, Hunt, Peter, Janus, Diana, Lewis, Sarah, Oakley, Paul, O'Connor, Des, Reilly, John, Smith, Nichola and Press, Neil J (2014) The discovery of potent, orally bioavailable pyrimidine-5-carbonitrile-6-alkyl CXCR2 receptor antagonists. Bioorganic & Medicinal Chemistry Letters, 24 (15). pp. 3285-3290. ISSN 0960-894X

McKeown, Stephen C, Charlton, Steven J, Cox, Brian, Fitch, Helen, Howson, Christopher D, Leblanc, Catherine, Meyer, Arndt, Rosethorne, Elizabeth M and Stanley, Emily (2014) Identification of novel IP receptor agonists using historical ligand biased chemical arrays. Bioorganic & Medicinal Chemistry Letters, 24 (10). pp. 2247-2250. ISSN 0960-894X

Porter, David W, Bradley, Michelle, Brown, Zarin, Canova, Riccardo, Charlton, Steven, Cox, Brian, Hunt, Peter, Kolarik, David, Lewis, Sarah, O'Connor, Des, Reilly, John, Spanka, Carsten, Tedaldia, Lauren, Watson, Simon J, Wermuth, Roland and Press, Neil J (2014) The discovery of potent, orally bioavailable pyrazolo and triazolopyrimidine CXCR2 receptor antagonists. Bioorganic & Medicinal Chemistry Letters, 24 (1). pp. 72-76. ISSN 0960-894X

Sandham, David A, Arnold, Nicola, Aschauer, Heinrich, Bala, Kamlesh, Barker, Lucy, Brown, Lyndon, Brown, Zarin, Budd, David, Cox, Brian, Docx, Cerys, Dubois, Gerald, Duggan, Nicholas, England, Karen, Everatt, Brian, Furegati, Marcus, Hall, Edward, Kalthoff, Frank, King, Anna, Leblanc, Catherine J, Manini, Jodie, Meingassner, Josef, Profit, Rachael, Schmidt, Alfred, Simmons, Jennifer, Sohal, Bindi, Stringer, Rowan, Thomas, Matthew, Turner, Katharine L, Walker, Christoph, Watson, Simon J, Westwick, John, Willis, Jennifer, Williams, Gareth and Wilson, Caroline (2013) Discovery and characterization of NVP-QAV680, a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases. Bioorganic & Medicinal Chemistry, 21 (21). pp. 6582-6591. ISSN 0968-0896

Bruce, Ian, Akhlaq, Mohammed, Bloomfield, Graham C, Budd, Emma, Cox, Brian, Cuenoud, Bernard, Finan, Peter, Gedeck, Peter, Hatto, Julia, Hayler, Judy F, Head, Denise, Keller, Thomas, Kirman, Louise, Leblanc, Catherine, Le Grand, Darren, McCarthy, Clive, O'Connor, Desmond, Owen, Charles, Oza, Mrinalini S, Pilgrim, Gaynor, Press, Nicola E, Sviridenko, Lilya and Whitehead, Lewis (2012) Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway. Bioorganic and Medicinal Chemistry Letters, 22 (17). pp. 5445-5450. ISSN 0960-894X

Hunt, Thomas, Atherton-Watson, Hazel C, Axford, Jake, Collingwood, Stephen P, Coote, Kevin J, Cox, Brian, Czarnecki, Sarah, Danahay, Henry, Devereux, Nick, Howsham, Catherine, Hunt, Peter, Paddock, Victoria, Paisley, Derek and Young, Alice (2012) Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 1: Quaternary amines. Bioorganic and Medicinal Chemistry Letters, 22 (2). pp. 929-932. ISSN 0960-894X

Wrigglesworth, Joe W, Cox, Brian, Lloyd-Jones, Guy C and Booker-Milburn, Kevin I (2011) New heteroannulation reactions of n-alkoxybenzamides by Pd(II) catalyzed C–H activation. Organic Letters, 13 (19). pp. 5326-5329. ISSN 1523-7060

Elliott, Luke D, Wrigglesworth, Joe W, Cox, Brian, Lloyd-Jones, Guy C and Booker-Milburn, Kevin I (2011) 2,2-Difunctionalization of alkenes via Pd(II)-catalyzed Aza-Wacker reactions. Organic Letters, 13 (4). pp. 728-731. ISSN 1523-7060

Reilly, John, Etheridge, Donnya, Everatt, Brian, Jiang, Zhengjin, Aldcroft, Clive, Wright, Penny, Clemens, Ian, Cox, Brian, Press, Neil J, Watson, Simon, Porter, David, Springer, Clayton and Fairhurst, Robin A (2011) Studies in drug albumin binding using HSA and RSA affinity methods. Journal of Liquid Chromatography and Related Technologies, 34 (4). pp. 317-327. ISSN 1082-6076

Beattie, David, Brearley, Andrew, Brown, Zarin, Charlton, Steven J, Cox, Brian, Fairhurst, Robin A, Fozard, John R, Gedeck, Peter, Kirkham, Paul, Meja, Koremu, Nanson, Lana, Neef, James, Oakman, Helen, Spooner, Gillian, Taylor, Roger J, Turner, Robert J, West, Ryan and Woodward, Hannah (2010) Synthesis and evaluation of two series of 4′-aza-carbocyclic nucleosides as adenosine A2A receptor agonists. Bioorganic and Medicinal Chemistry Letters, 20 (3). pp. 1219-1224. ISSN 0960-894X

Sandham, David A, Adcock, Claire, Bala, Kamlesh, Barker, Lucy, Brown, Zarin, Dubois, Gerald, Budd, David, Cox, Brian, Fairhurst, Robin A, Furegati, Markus, Leblanc, Catherine, Manini, Jodie, Profit, Rachael, Reilly, John, Stringer, Rowan, Schmidt, Alfred, Turner, Katharine L, Watson, Simon J, Willis, Jennifer, Williams, Gareth and Wilson, Caroline (2009) 7-Azaindole-3-acetic acid derivatives: potent and selective CRTh2 receptor antagonists. Bioorganic and Medicinal Chemistry Letters, 19 (16). pp. 4794-4798. ISSN 0960-894X

Stansfeld, Phillip J, Grottesi, Alessandro, Sands, Zara A, Sansom, Mark S P, Gedeck, Peter, Gosling, Martin, Cox, Brian, Stanfield, Peter R, Mitcheson, John S and Sutcliffe, Michael J (2008) Insight into the mechanism of inactivation and pH sensitivity in potassium channels from molecular dynamics simulations. Biochemistry, 47 (28). pp. 7414-7422. ISSN 0006-2960

Sandham, David A, Aldcroft, Clive, Baettig, Urs, Barker, Lucy, Beer, David, Bhalay, Gurdip, Brown, Zarin, Dubois, Gerald, Budd, David, Bidlake, Louise, Campbell, Emma, Cox, Brian, Everatt, Brian, Harrison, David, Leblanc, Catherine J, Manini, Jodie, Profit, Rachael, Stringer, Rowan, Thompson, Katy S, Turner, Katharine L, Tweed, Morris F, Walker, Christopher, Watson, Simon J, Whitebread, Steven, Willis, Jennifer, Williams, Gareth and Wilson, Caroline (2007) 2-Cycloalkyl phenoxyacetic acid CRTh2 receptor antagonists. Bioorganic and Medicinal Chemistry Letters, 17 (15). pp. 4347-4350. ISSN 0960-894X

Stansfeld, Phillip J, Gedeck, Peter, Gosling, Martin, Cox, Brian, Mitcheson, John S and Sutcliffe, Michael J (2007) Drug block of the hERG potassium channel: insight from modeling. Proteins: Structure, Function, and Bioinformatics, 68 (2). pp. 568-580. ISSN 0887-3585

Wall, Michael D, Oshin, Michael, Chung, Gavin A C, Parkhouse, Tony, Gore, Andrea, Herreros, Esperanza, Cox, Brian, Duncan, Ken, Evans, Brian, Everett, Martin and Mendoza, Alfonso (2007) Evaluation of N-(phenylmethyl)-4-[5-(phenylmethyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-4-yl]benzamide inhibitors of Mycobacterium tuberculosis growth. Bioorganic and Medicinal Chemistry Letters, 17 (10). pp. 2740-2744. ISSN 0960-894X

Al-Hiari, Yusuf M, Bennett, Stephen J, Davies, Robert J, Khalaf, Abedawn I, Waigh, Roger D, Worsley, Alan J and Cox, Brian (2005) Steps towards a practical synthesis of macrocyclic bisbenzylisoquinolines. Journal of Heterocyclic Chemistry, 42 (4). pp. 647-659. ISSN 0022-152X

Li, Su, Gosling, Martin, Poll, Chris T, Westwick, John and Cox, Brian (2005) Therapeutic scope of modulation of non-voltage-gated cation channels. Drug Discovery Today, 10 (2). pp. 129-137. ISSN 1359-6446

Booker-Milburn, Kevin I, Guly, Dominic J, Cox, Brian and Procopiou, Panayiotis A (2003) Ritter type reactions of N-Chlorosaccharin: a method for the electrophilic diamination of alkenes. Organic Letters, 5 (18). pp. 3313-3315. ISSN 1523-7060

Stratton, Sharon C, Large, Charles H, Cox, Brian, Davies, Gary and Hagan, Russell M (2003) Effects of lamotrigine and levetiracetam on seizure development in a rat amygdala kindling model. Epilepsy Research, 53 (1-2). pp. 95-106. ISSN 0920-1211

Cox, Brian (2000) Calcium channel blockers and pain therapy. Current Review of Pain, 4 (6). pp. 488-498. ISSN 1069-5850

Cox, Brian, Morley, Nicolas, Procopiou, Panayiotis A, Sharratt, Peter J, Watson, Nigel S and Wild, Deborah (2000) The squalestatins: tricyclic 3,4-β-lactone and 3,4-oxetane systems. Tetrahedron Letters, 41 (39). pp. 7547-7550. ISSN 0040-4039

Main, Martin J, Cryan, Jennifer E, Cox, Brian, Dupere, Joe R B, Clare, Jeffrey J and Burbidge, Stephen A (2000) Modulation of KCNQ 2/3 potassium channels by the novel anticonvulsant retigabine. Molecular Pharmacology, 58 (2). pp. 253-262. ISSN 0026-895X

Booker-Milburn, Kevin I, Cox, Brian, Grady, Mick, Halley, Frank and Marrison, Shaun (2000) Fe(III)/Cu(II) mediated 5- and 6-exo oxidative ring expansion/cyclisation of cyclopropyl ethers: studies towards dictyol C and α-eudesmol. Tetrahedron Letters, 41 (23). pp. 4651-4655. ISSN 0040-4039

Cox, Brian, Merritt, Andy T, Binnie, Alastair, Donnelly, Mary C, Mander, Tom H, Denyer, Jane C, Evans, Brian, Green, Darren V S, Lewis, Jane A, Valler, Martin J and Watson, Stephen P (2000) Application of high-throughput screening techniques to drug discovery. Progress in Medicinal Chemistry, 37. pp. 83-133. ISSN 0079-6468

Booker-Milburn, Kevin I, Barker, Andy, Brailsford, Wayne, Cox, Brian and Mansley, Tamsin E (1998) Fe(III) mediated oxidative radical cyclisation of cyclopropanone acetals. Tetrahedron, 54 (50). pp. 15321-15344. ISSN 0040-4020

Cox, Brian and Denyer, Jane C (1998) N-type calcium channel blockers in pain and stroke. Expert Opinion on Therapeutic Patents, 8 (10). pp. 1237-1250. ISSN 1354-3776

Mahmoudian, Mahmoud, Rudd, Brian A M, Cox, Brian, Drake, Chris S, Hall, Richard M, Stead, Paul, Dawson, Michael J, Chandler, Malcolm, Livermore, David G, Turner, Nicholas J and Jenkins, Gareth (1998) A versatile procedure for the generation of nucleoside 5'-carboxylic acids using nucleoside oxidase. Tetrahedron, 54 (28). pp. 8171-8182. ISSN 0040-4020

Denyer, Jane, Worley, Jennings, Cox, Brian, Allenby, Gary and Banks, Martyn (1998) HTS approaches to voltage-gated ion channel drug discovery. Drug Discovery Today, 3 (7). pp. 323-332. ISSN 1359-6446

Cagnolini, Cristiano, Ferri, Marina, Jones, Peter R, Murphy, Patrick J, Ayres, Barry and Cox, Brian (1997) Synthesis and epimerisation studies on carbohydrate derived bicyclic tetronate esters: the synthesis of furanofurans related to the cytotoxic metabolite goniofufurone. Tetrahedron, 53 (13). pp. 4815-4820. ISSN 0040-4020

Booker-Milburn, Kevin I, Cox, Brian and Mansley, Tamsin E (1996) Iron(III)-mediated oxidative cyclisations of cyclopropanone acetals. Chemical Communications, 22. pp. 2577-2578. ISSN 1359-7345

Chan, Chuen, Andreotti, Daniele, Cox, Brian, Dymock, Brian W, Hutson, Julie L, Keeling, Suzanne E, McCarthy, Alun D, Procopiou, Panayiotis A, Ross, Barry C, Sareen, Meenu, Scicinski, Jan J, Sharratt, Peter J, Snowden, Michael A and Watson, Nigel S (1996) The squalestatins: decarboxy and 4-deoxy analogues as potent squalene synthase inhibitors. Journal of Medicinal Chemistry, 39 (1). pp. 207-216. ISSN 0022-2623

Procopiou, Panayiotis A, Cox, Brian, Kirk, Barrie E, Lester, Michael G, McCarthy, Alun D, Sareen, Meenu, Sharratt, Peter J, Snowden, Michael A, Spooner, Stephen J, Watson, Nigel S and Widdowson, Julia (1996) The squalestatins: inhibitors of squalene synthase. Enzyme inhibitory activities and in vivo evaluation of C-3 modified analogues. Journal of Medicinal Chemistry, 39 (7). pp. 1413-1422. ISSN 0022-2623

Smith, Paul W, Lai, Justine Y Q, Whittington, Andrew R, Cox, Brian, Houston, John G, Stylli, C Harri, Banks, Martyn N and Tiller, Philip R (1994) Synthesis and biological evaluation of a library containing potentially 1600 amides / esters. A strategy for rapid compound generation and screening. Bioorganic and Medicinal Chemistry Letters, 4 (24). pp. 2821-2824. ISSN 0960-894X

Cox, Brian, Hutson, Julie L, Keeling, Suzanne E, Kirk, Barrie E, Srikantha, Anton R P and Watson, Nigel S (1994) The squalestatins: potent inhibitors of squalene synthase, 3-hydroxymethyl derivatives. Bioorganic and Medicinal Chemistry Letters, 4 (16). pp. 1931-1936. ISSN 0960-894X

Watson, Nigel S, Bell, Richard, Chan, Chuen, Cox, Brian, Hutson, Julie L, Keeling, Suzanne E, Kirk, Barrie E, Procopiou, Panayiotis A, Steeples, Ian P and Widdowson, Julia (1993) The squalestatins: potent inhibitors of squalene synthase. The role of the tricarboxylic acid moiety. Bioorganic and Medicinal Chemistry Letters, 3 (12). pp. 2541-2546. ISSN 0960-894X

McCombie, Stuart W, Cox, Brian, Lin, Sue-Ing, Ganguly, Ashit K and McPhail, Andrew T (1991) Controlling benzylic functionality and stereochemistry: 1. Synthesis of the secopseudopterosin aglycone. Tetrahedron Letters, 32 (19). pp. 2083-2086. ISSN 0040-4039

McCombie, Stuart W, Cox, Brian and Ganguly, Ashit K (1991) Controlling benzylic functionality and stereochemistry: 2. Synthesis of the pseudopterosin aglycone. Tetrahedron Letters, 32 (19). pp. 2087-2090. ISSN 0040-4039

Ganguly, A K, McCombie, S W, Cox, B, Lin, S and McPhail, A I (1990) Stereospecific synthesis of the aglycone of pseudopterosin E. Pure and Applied Chemistry, 62 (7). pp. 1289-1291. ISSN 0033-4545

Cox, Brian and Waigh, Roger D (1989) A modified synthesis of 4-chromanones. Synthesis, 1989 (9). pp. 709-710. ISSN 0039-7881

Cox, Brian and Robinson, Brian (1988) The reduction of 6-methoxy-9-methyl-11-oxoechiboline using lithium aluminium hydride. Journal of Heterocyclic Chemistry, 25 (1). pp. 271-272. ISSN 0022-152X

Cox, B and Waugh, R D (1987) The octanol-water partition coefficient of Mannich's base. Journal of Pharmacy and Pharmacology, 39. 117P. ISSN 0022-3573

Cox, B and Waigh, R D (1986) The activity of 2-(2-pyridyl)acetophenones against Candida albicans. Journal of Pharmacy and Pharmacology, 38 (S12). 46P. ISSN 0022-3573

Cox, B, Gilbert, P and Waigh, R D (1983) The activity of the alkaloid O-methyl pleurospermine against cultures of Candida albicans. Journal of Pharmacy and Pharmacology, 35. 49P. ISSN 0022-3573

Book Section

Cox, Brian (2014) Ion channel drug discovery: a historical perspective. In: Cox, Brian and Gosling, Martin (eds.) Ion channel drug discovery. RSC drug discovery . Royal Society of Chemistry. ISBN 9781849731867

Li, Su, Westwick, John, Cox, Brian and Poll, Chris T (2004) TRP channels as drug targets. In: Mammalian TRP channels as molecular targets. Novartis Foundation Symposium, 258 . Wiley-Blackwell. ISBN 9780470862544

Buss, A D, Cox, B and Waigh, R D (2003) Natural products as leads for new pharmaceuticals. In: Abraham, Donald J (ed.) Burger's medicinal chemistry and drug discovery. Wiley-Blackwell. ISBN 9780471266945

Cox, B (2002) An introduction to ion channels. In: King, F D (ed.) Medicinal chemistry: principles and practice. Royal Society of Chemistry, pp. 25-41. ISBN 9780854046317

Edited Book

Cox, Brian and Gosling, Martin, eds. (2014) Ion channel drug discovery. RSC drug discovery . Royal Society of Chemistry. ISBN 9781849731867

Conference or Workshop Item

Cox, Brian (2014) Session chair: Hot topics in ion channels. In: XXIII International Symposium on Medicinal Chemistry, September 7-11, 2014, Lisbon, Portugal.

Cox, Brian, Clemens, Ian, Eberle, Martin, Edwards, Lee, Koch, Guido, Pascoe, David, Robinson, Richard, Booker-Milburn, Kevin and Elliot, Luke (2013) Considerations in scaling flow photochemical processes; utilisation of a simple flow reactor setup. In: 2nd SCI/RSC Symposium on Continuous Processing and Flow Chemistry, 24-25 September 2013, Novartis, Horsham, UK.

Danahay, H, Coote, K, Paisley, D, Czarnecki, S, Atherton, H, Young, A, Gosling, M, Abraham, W, Sabater, J, Lock, R, Smith, N, Stanley, E, Butler, R, Bloomfield, G, Baettig, U, Cox, B and Collingwood, S P (2010) Novel dimeric amiloride derivatives: airway efficacy & reduced renal-based side effects. In: The 24th Annual North American Cystic Fibrosis Conference, October 21-23, 2010, Baltimore, Maryland, USA.

Baettig, Urs, Butler, Rebecca, Smith, Nichola, Stanley, Emily, Oakley, Paul, Danahay, Henry, Coote, Kevin, Atherton, Hazel, Paisley, Derek, Lock, Ruth, Cox, Brian and Collingwood, Steve (2010) Dimeric modulators of ENaC for the treatment of cystic fibrosis. In: ACS Fall 2010 National Meeting, August 22-26, 2010, Boston, MA.

Cox, Brian (2009) Co-organiser and session chair: Ion channels as therapeutic targets. In: Ion Channels as Therapeutic Targets, 2009, Novartis, Horsham, UK.

Baettig, U, Collingwood, S, Janus, D, Devereux, N, Stanley, E, Cox, B, McCarthy, C, Charlton, S, Leighton-Davis, J, Fozard, J R, Baur, F, Farr, D, Mazzoni, L and Patel, V (2007) Discovery of long acting inhaled muscarinic M3 receptor antagonists. In: 233rd American Chemical Society National Meeting, March 25-29, 2007, Chicago, IL USA.

Cox, Brian (2004) Co-organiser and presenter: Ion channels: a wealth of opportunity. In: RSC Biological and Medicinal Chemistry Sector, 2004, GSK, Harlow.

Cox, Brian (2003) Ion channels – where next? In: RSC Biological and Medicinal Chemistry Sector and the RSC Molecular Modelling Group, 2003, SCI, London.

Ley, S V, Healy, M P and Cox, B (2001) Studies toward the total synthesis of the potent antimitotic agent: Spongistatin. In: 222nd American Chemical Society National Meeting, August 26 - 30, 2001, Chicago, IL USA.

Cox, Brian (2001) The structure activity relationships of sodium channel blockers. In: The role of sodium channel blockers in disease, 2003, Society for Medicines Research, London.

Burbidge, S, Main, M, Cryan, J, Cox, B and Clare, J (2000) Modulation of KCNQ potassium channels by retigabine. In: Potassium Channels: Structure, Function and Therapeutic Utilities, 2000, Keystone Symposium, Tahoe City.

Cox, B, Edney, D, Healy, M, Loft, M, Nobbs, M S, Rider, P, Shah, G P, Squires, B and Wild, D (1999) GW273293X: a potential broad spectrum anticonvulsant. In: 217th American Chemical Society National Meeting, 21-25 March 1999, Anaheim, CA, USA.

Wild, D, Cox, B, Edney, D, Healy, M, Loft, M, Nobbs, M S, Rider, P, Shah, G and Squires, B (1998) Sodium channel inhibitors 3: GW273293X as a potential broad spectrum anticonvulsant. In: 15th European Federation of Medicinal Chemistry International Symposium on Medicinal Chemistry, 1998, Edinburgh.

Mansley, T E, Booker-Milburn, K I and Cox, B (1996) Iron (III)-mediated free radical transformations of cyclopropanone acetals. In: 212th American Chemical Society national meeting, August 25-29, 1996, Orlando, FL, USA.

Cox, B, Adams, H S, Bell, R, Cooper, A W J, Gore, P M, Pritchard, J M, Saez, V and Ward, P (1995) Analogues of GR159897 a highly potent, non-peptide neurokinin-A NK2 receptor antagonist. In: 209th American Chemical Society National Meeting, 2-6 April 1995, Anaheim, California.

Davies, R J, Cox, B and Waigh, R D (1994) Synthesis of Bisbenzyl isoquinolines with potential anti viral activity. In: 2nd Bath International Symposium on Medicinal Chemistry, September 1994, Bath, UK.

Chan, C, Andreotti, D, Cox, B, Dymock, B W, Inglis, G G A, Keeling, S E, McCarthy, A D, Procopiou, P A, Ross, B C, Sareen, M, Scicinski, J J, Sharratt, P J, Srikantha, A R P and Watson, N S (1994) The Squalestatins: decarboxy and 4-Deoxy analogues as potent squalene synthase inhibitors. In: 207th American Chemical Society National Meeting, March 13-17, 1994, San Diego, CA, USA.

Ross, B C, Chan, C, Cox, B, Evans, G L, Giblin, G M P, Lester, M G, McCarthy, A D, Procopiou, P A, Sareen, M, Sharratt, P J and Watson, N S (1993) The squalestatins: potent inhibitors of squalene synthase. In: 206th American Chemical Society National Meeting, August 22-27, 1993, Chicago, Illinois, USA.

Adams, H S, Ball, D, Bell, R, Beresford, I J M, Coleman, R A, Cooper, A W J, Cox, B, Deal, M J, Gore, P M, Hagan, R M, McElroy, A B, Pendry, Y, Pritchard, J M, Saez, V, Sheldrick, R L G, Smith, P W, Stratton, S, Walsh, D M and Ward, P (1993) GR159897; a potent and selective non-peptide NK2 antagonist. In: 7th RSC-SCI Med.Chem. Symposium, 1993, Cambridge.

McCombie, S W, Cox, B and Ganguly, A K (1989) Synthetic studies on pseudopterosins: controlling stereo chemistry at benzylic centres. In: Gordon Conference, 1989.

Patent

Novartis AG, Cox, B et al (2007) 5-phenylthiazol-2-ylureas as phosphatidylinositol 3-kinase (PI3 kinase) inhibitors. WO2007134827.

Novartis AG, Cox, B et al (2007) Preparation of pyrazolo[3,4-d]pyrimidine derivatives for treating respiratory disorders. WO2007134828.

Novartis AG, Cox, B et al (2007) Purine derivatives for use as adenosin A2A receptor agonists. WO2007121920.

Novartis AG, Cox, B et al (2006) Organic compounds. WO/2006/125593.

Novartis AG, Bala, K J, Cox, B et al (2006) Organic compounds for the treatment of imflammatory or alleric conditions. WO2006125596.

Novartis AG, Cox, B et al (2006) Quinuclidine derivatives and their use as muscarinic M3 receptor antagonists. WO/2006/048225.

Novartis AG, Bala, K, Cox, B et al (2005) Pyrrolopyridine derivatives and their use as CRTh2 antagonists. WO/2005/123731.

Glaxo Group Ltd., Cox, B et al (2005) Phenethanolamine derivatives for treatment of respiratory diseases. WO/2005/058299.

Novartis AG, Cox, B et al (2004) Quinuclidine derivatives binding to mucarinic M3 receptors. WO/2004/096800.

Glaxo Group Ltd., Cox, B et al (2002) Use of bicyclic esters or amides for the treatment of diseases responsive to enhanced potassium channel activity. WO/2002/062745.

Glaxo Group Limited, Cox, B et al (2001) New uses potassium channel openers, such as the treatment of epilepsy. WO/2001/001970.

Glaxo Group Limited, Cox, B et al (2000) Pyrazine compounds. WO/2000/012488.

Glaxo Group Limited, Cox, B et al (1999) 2-(Purin-9-yl)-tetrahydrofuran-3,4-diol derivatives. WO/1999/067263.

Glaxo Group Limited, Cox, B et al (1999) 2-(Purin-9-yl)-tetrahydrofuran-3,4-diol derivatives. WO/1999/067264.

Glaxo Group Limited, Cox, B et al (1999) 2-(Purin-9-yl)-tetrahydrofuran-3,4-diol derivatives. WO/1999/067265.

Glaxo Group Limited, Cox, B et al (1999) 2-(Purin-9-yl)-tetrahydrofuran-3,4-diol derivatives. WO/1999/067266.

Glaxo Group Limited, Cox, B et al (1999) 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives. WO/1999/041267.

Glaxo Group Limited, Cox, B et al (1999) 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives. WO/1999/038877.

Glaxo Group Limited, Cox, B et al (1999) Triazine compounds for treatment of CNS disorders. WO/1999/032462.

Glaxo Group Limited, Cox, B et al (1999) Adenosine A1 receptor agonists. WO/1999/024449.

Glaxo Group Limited, Cox, B et al (1998) Pyrazine compounds. WO/1998/038174.

Glaxo Group Limited, Cox, B et al (1998) 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives. WO/1998/028319.

Glaxo Group Limited, Cox, B et al (1997) Adenosine derivatives. WO/1997/043300.

Glaxo Group Limited, Cox, B et al (1993) Cyclic ketal derivatives. WO/1993/007151.

Glaxo Group Limited, Cox, B et al (1992) Bridged cyclic ketal derivatives. WO/1992/012160.

The Victoria University of Manchester, B Cox et al (1988) New organic compounds having opioid properties. WO/1988/000193.