Photo of Jon Baxter

Jon Baxter
Research Fellow (Genome Damage and Stability)
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T: +44 (0)1273 876637

Research

Research in the Baxter lab focuses on the process of chromosome resolution. During chromosome replication the sister chromatids become entangled. All such entanglements need to be resolved before the chromosomes can be faithfully segregated to the daughter cells during mitosis. In particular we study the series of events that initially generates double stranded intertwines or catenanes during the termination phase of DNA replication and the processes that ensure all the catenanes generated during termination are resolved during G2 and mitosis.

Failure to resolve chromosomes leads to the daughter cells not having the normal complement of genetic information. This leads to either cell death or widespread genomic instability – a potential pathway to cancer.

We principally tackle these issues in the budding yeast system. The sophisticated genetics available in this model organism allows careful dissection of the pathways involved in chromosome resolution. This produces detailed and coherent mechanisms for the action of these pathways that can then be tested in more intractable mammalian cells