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Mark Roe
X-Ray Crystallography Collaborative Research Facility Manager (Biochemistry)
E:
T: +44 (0)1273 678863

Selected publications

Article

Inman, Christopher J, Frey, Alistair S P, Kilpatrick, Alexander F R, Cloke, F Geoffrey and Roe, S Mark (2017) Carbon dioxide activation by a uranium(III) complex derived from a chelating bis(aryloxide) ligand. Organometallics. ISSN 0276-7333

Blundell, Katie L I M, Pal, Mohinder, Roe, S Mark, Pearl, Laurence H and Prodromou, Chrisostomos (2017) The structure of FKBP38 in complex with the MEEVD tetratricopeptide binding-motif of Hsp90. PLoS ONE, 12 (3). e0173543. ISSN 1932-6203

Saunders, Amy J, Crossley, Ian R and Roe, S Mark (2016) Aroylphosphanes: base-free synthesis and their coordination chemistry with platinum-group metals. European Journal of Inorganic Chemistry, 2016 (25). pp. 4076-4082. ISSN 1434-1948

Morgan, Rhodri M L, Pal, Mohinder, Roe, S Mark, Pearl, Laurence H and Prodromou, Chrisostomos (2015) Tah1 helix-swap dimerization prevents mixed Hsp90 co-chaperone complexes. Acta Crystallographica Section D: Biological Crystallography, D71. pp. 1197-1206. ISSN 1399-0047

Guest, Daniel, Menezes da Silva, Victor H, de Lima Batista, Anna P, Roe, S Mark, Braga, Ataualpa A C and Navarro, Oscar (2015) (N-heterocyclic carbene)-palladate complexes in anionic Mizoroki-Heck coupling cycles: a combined experimental and computational study. Organometallics, 34 (11). pp. 2463-2470. ISSN 0276-7333

Higgins Frey, Jessica A, Cloke, F Geoffrey N and Roe, S Mark (2015) Synthesis and reactivity of a mixed-sandwich uranium(IV) primary amido complex. Organometallics, 34 (11). pp. 2102-2105. ISSN 0276-7333

Button, Zoë E, Higgins, Jessica A, Suvova, Markéta, Cloke, F Geoffrey N and Roe, S Mark (2015) Mixed sandwich thorium complexes incorporating bis(tri-isopropylsilyl)cyclooctatetraenyl and pentamethylcyclopentadienyl ligands: synthesis, structure and reactivity. Dalton Transactions, 44. pp. 2588-2596. ISSN 1477-9226

Maluenda, Irene, Chen, Ming-Tsz, Guest, Daniel, Roe, Mark, Turner, Michael L and Navarro, Oscar (2015) Room temperature, solventless telomerization of isoprene with alcohols using (N-heterocyclic carbene)–palladium catalysts. Catalysis Science and Technology, 5. pp. 1447-1451. ISSN 2044-4753

Greenacre, Victoria, Ansell, Melvyn, Roe, Mark and Crossley, Ian (2014) Synthesis, structures and coordination chemistry of singly bridged phosphane-boranes with coordinately unsaturated platinum group metals. European Journal of Inorganic Chemistry, 2014 (29). pp. 5053-5062. ISSN 1434-1948

Pal, Mohinder, Morgan, Marc, Phelps, Sarah E L, Roe, S Mark, Parry-Morris, Sarah, Downs, Jessica, Polier, Sigrun, Pearl, Laurence and Prodromou, Chrisostomos (2014) Structural basis for phosphorylation-dependent recruitment of tel2 to hsp90 by pih1. Structure, 22 (6). pp. 805-818. ISSN 1878-4186

Kefalidis, Christos E, Frey, Alistair S P, Roe, S Mark, Cloke, F Geoffrey N and Maron, Laurent (2014) Formation of cyanates in low-valent uranium chemistry: a synergistic experimental/theoretical study. Dalton Transactions, 2014 (43). pp. 11202-11208. ISSN 1477-9226

Dutton, Bridie L, Kitson, Russell R A, Parry-Morris, Sarah, Roe, S Mark, Prodromou, Chrisostomos and Moody, Chrisostomos (2014) Synthesis of macrolactam analogues of radicicol and their binding to heat shock protein Hsp90. Organic and Biomolecular Chemistry, 12 (8). pp. 1328-1340. ISSN 1477-0520

Trathen, Nicola, Greenacre, Victoria K, Crossley, Ian R and Roe, S Mark (2013) Ambiphilic reactivity of a ruthenaphosphaalkenyl: synthesis of P‑pyrazolylphosphaalkene complexes of ruthenium(0). Organometallics, 32 (9). pp. 2501-2504. ISSN 0276-7333

Newcombe, Sonya, Bobin, Mariusz, Shrikhande, Amruta, Gallop, Chris, Pace, Yannick, Yong, Helen, Gates, Rebecca, Chaudhuri, Shuvashri, Roe, Mark, Hoffmann, Eva and Viseux, Eddy M E (2013) Gold amides as anticancer drugs: synthesis and activity studies. Organic and Biomolecular Chemistry, 19 (11). pp. 3255-3260. ISSN 1477-0520

Trathen, Nicola, Greenacre, Victoria K, Crossley, Ian and Roe, Mark (2013) Ambiphilic reactivity of a ruthenaphosphaalkenyl: synthesis of P-pyrazolylphosphaalkene complexes of ruthenium(0). Organometallics, 32 (9). pp. 2501-2504. ISSN 0276-7333

Gallop, Chris W D, Bobin, Mariusz, Hourani, Petra, Dwyer, Jessica, Roe, S Mark and Viseux, Eddy (2013) Investigation of the reductive cleavage of BINAP and application to the rapid synthesis of phospholes. Journal of Organic Chemistry, 78 (13). pp. 6522-6528. ISSN 0022-3263

Saunders, Amy J, Crossley, Ian R, Coles, Martyn P and Roe, S Mark (2012) Facile self-assembly of the first diphosphametacyclophane. Chemical Communications, 48. pp. 5766-5768. ISSN 1359-7345

Day, James E H, Sharp, Swee Y, Rowlands, Martin G, Aherne, Wynne, Lewis, William, Roe, S Mark, Prodromou, Chrisostomos, Pearl, Laurence H, Workman, Paul and Moody, Christopher J (2010) Inhibition of Hsp90 with resorcylic acid macrolactones: synthesis and binding studies. Chemistry - A European Journal, 16 (34). pp. 10366-10372. ISSN 0947-6539

Roe, Mark, Alaoui, Hicham, Barford, David, Diogon, Marie, Kong, Eric and Zhang, Ziguo (2010) Molecular structure of the N-terminal domain of the APC/C subunit Cdc27 reveals a homo-dimeric tetratricopeptide repeat architecture. Journal of Molecular Biology, 397 (5). pp. 1316-1328. ISSN 0022-2836

Roe, M, Bayliss, R, Chen, J, Leung, J, Li, K and Richards, M (2010) A pocket on the surface of the N-terminal BRCT domain of Mcph1 is required to prevent abnormal chromosome condensation. Journal of Molecular Biology, 395 (5). pp. 908-915. ISSN 0022-2836

Roe, Mark, Barford, D, Marshall, C, Yang, J and Zhang, Z (2009) Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor. Science, 325 (5946). pp. 1398-1402. ISSN 0036-8075

Bunney, Tom D, Opaleye, Olanivi, Roe, S Mark, Vatter, Petra, Baxendale, Rhona W, Walliser, Claudia, Everett, Katy L, Josephs, Michelle B, Christow, Carolin, Rodrigues-Lima, Fernando, Gierschik, Peter, Pearl, Laurence H and Katan, Matilda (2009) Structural Insights into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2. Molecular Cell, 34 (2). pp. 223-233. ISSN 1097-2765

Roe, M, Barford, D, Parizotto, E, Parker, J and Wang, M (2009) Enhancement of the seed-target recognition step in RNA silencing by a PIWI/MID domain protein. Molecular Cell, 33 (2). pp. 204-214. ISSN 1097-2765

Roe, Mark, Odho, Zain, Southall, Stacey, Wilson, Jon and Wong, Poon-Sheng (2009) Structural basis for the requirement of additional factors for MLL1 SET domain activity and recognition of epigenetic marks. Molecular Cell, 33 (2). pp. 181-191. ISSN 1097-2765

Kilkenny, Mairi L, Doré, Andrew S, Roe, S Mark, Nestoras, Konstantinos, Ho, Jenny C Y, Watts, Felicity Z and Pearl, Laurence H (2008) Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signalling. Genes and Development, 22 (15). pp. 2034-47. ISSN 0890-9369

Kilkenney, M L, Dore, A, Roe, S M, Nestoras, K, Ho, J, Watts, F Z and Pearl, L (2008) Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair. Genes and Development, 22 (15). pp. 2034-2047. ISSN 0890-9369

Martin, Christine J, Gaisser, Sabine, Challis, Iain R, Carletti, Isabelle, Wilkinson, Barrie, Gregory, Matthew, Prodromou, Chrisostomos, Roe, S Mark, Pearl, Laurence H, Boyd, Susan M and Zhang, Ming-Qiang (2008) Molecular characterization of macbecin as an Hsp90 inhibitor. Journal of Medicinal Chemistry, 51 (9). pp. 2853-2857. ISSN 0022-2623

Roe, Mark, Hassler, Markus, Pearl, Laurence, Thompson-Vale, Vivienne and Yue, Wyatt (2007) Insights into histone code syntax from structural and biochemical studies of CARM1 methyltransferase. EMBO Journal, 26 (20). pp. 4402-4412. ISSN 0261-4189

Roe, M, Barford, D, Brautigan, D, Prickett, T and Yang, J (2007) The structure of Tap42/alpha4 reveals a tetratricopeptide repeat-like fold and provides insights into PP2A regulation. Biochemistry, 46 (30). pp. 8807-8815. ISSN 0006-2960

Roe, Mark (2007) Reversible oxidation of the membrane distal domain of receptor PTPalpha is mediated by a cyclic sulfenamide. Biochemistry, 46. pp. 709-719.

Sharp, Swee Y, Boxall, Kathy, Rowlands, Martin, Prodromou, Chrisostomos, Roe, S Mark, Maloney, Alison, Powers, Marissa, Clarke, Paul A, Box, Gary, Sanderson, Sharon, Patterson, Lisa, Matthews, Thomas P, Cheung, Kwai-Ming J, Ball, Karen, Hayes, Angela, Raynaud, Florence, Marais, Richard, Pearl, Laurence, Eccles, Sue, Aherne, Wynne, McDonald, Edward and Workman, Paul (2007) In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors. Cancer Research, 67 (5). pp. 2206-2216. ISSN 0008-5472

Proisy, Nicolas, Sharp, Swee Y, Boxall, Kathy, Connelly, Stephen, Roe, S Mark, Prodromou, Chrisostomos, Slawin, Alexandra M Z, Pearl, Laurence H, Workman, Paul and Moody, Christopher J (2006) Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol. Chemistry and Biology, 13 (11). pp. 1203-1215. ISSN 1074-5521

Roe, Mark, Bell, Stephen, Doré, Andrew, Sarah, Jones, Kilkenny, Mairi, Pearl, Laurence and Oliver, Antony (2006) Structure of an archaeal PCNA1-PCNA2-FEN1 complex: elucidating PCNA subunit and client enzyme specificity. Nucleic Acids Research, 34 (16). pp. 4515-4526. ISSN 0305-1048

Roe, Mark, Ish-Horowicz, David, Jennings, Barbara, Pearl, Laurence, Pickles, Laura and Wainwright, S Mark (2006) Molecular recognition of transcriptional repressor motifs by the WD domain of the Groucho/TLE corepressor. Molecular Cell, 22 (5). pp. 645-655. ISSN 1097-2765

Ali, Maruf M U, Roe, S Mark, Vaughan, Cara K, Meyer, Phillipe, Panaretou, Barry, Piper, Peter W, Prodromou, Chrisostomos and Pearl, Laurence H (2006) Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex. Nature, 440. pp. 1013-1017. ISSN 0028-0836

Roe, Mark, Barford, D and Parker, J (2006) Molecular mechanism of target RNA transcript recognition by Argonaute-guide complexes. Cold Spring Harbour Symposium on Quantitative Biology, 71. pp. 45-50.

Roe, Mark, Bunney, Tom, Driscoll, Paul, Esposito, Diego, Gierschik, Peter, Harris, Richard, Josephs, Michelle, Katan, Matilda, Lamuño Gandarillas, Natalia, Paterson, Hugh, Pearl, Laurence, Ponting, Chris, Rodrigues-Lima, Fernando and Sorli, S Caroline (2006) Structural and mechanistic insights into ras association domains of phospholipase C epsilon. Molecular Cell, 21 (4). pp. 495-507. ISSN 1097-2765

Zhang, Minghao, Windheim, Mark, Roe, S Mark, Peggie, Mark, Cohen, Philip, Prodromou, Chrisostomos and Pearl, Laurence H (2005) Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex. Molecular Cell, 20 (4). pp. 525-538. ISSN 1097-2765

Roe, Mark, Goodwin, G, Jones, S, Matthews, S, Pearl, L and Roe, S (2005) Crystal structure of the proximal BAH domain of the polybromo protein. Biochemistry, 389 (3). pp. 657-664.

Cheung, Kwai-Ming J, Matthews, Thomas P, James, Karen, Rowlands, Martin G, Boxall, Katherine J, Sharp, Swee Y, Maloney, Alison, Roe, S Mark, Prodromou, Chrisostomos, Pearl, Laurence H, Aherne, G Wynne, McDonald, Edward and Workman, Paul (2005) The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors. Bioorganic and Medicinal Chemistry Letters, 15 (14). pp. 3338-3343. ISSN 0960-894X

Roe, Mark, Barford, David and Parker, James (2005) Structural insights into mRNA recognition from a PIWI domain-siRNA guide complex. Nature, 434 (7033). pp. 663-666. ISSN 0028-0836

Roe, Mark (2005) Molecular basis for TPR domain-mediated regulation of protein phosphatase 5. EMBO Journal, 24 (1). pp. 1-10. ISSN 0261-4189

Meyer, Philippe, Prodromou, Chrisostomos, Liao, Chunyan, Hu, Bin, Roe, S Mark, Vaughan, Cara K, Vlasic, Ignacija, Panaretou, Barry, Piper, Peter W and Pearl, Laurence H (2004) Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery. EMBO Journal, 23 (6). pp. 1402-1410. ISSN 0261-4189

Oliver, A W, Amé, J C, Roe, S M, Good, V, de Murcia, G and Pearl, L H (2004) Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2. Nucleic Acids Research, 32 (2). pp. 456-464. ISSN 0305-1048

Roe, S Mark, Ali, Maruf M U, Meyer, Philippe, Vaughan, Cara K, Panaretou, Barry, Piper, Peter W, Prodromou, Chrisostomos and Pearl, Laurence H (2004) The mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37). Cell, 116 (1). pp. 87-98. ISSN 0092-8674

Meyer, Philipe, Prodromou, Chrisostomos, Hu, Bin, Vaughan, Cara, Roe, S Mark, Panaretou, Barry, Piper, Peter W and Pearl, Laurence H (2003) Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions. Molecular Cell, 11 (3). pp. 647-658. ISSN 1097-2765

Hinks, J, Roe, Mark, Ho, J C, Watts, Felicity, Phelan, J, McAllister, M and Pearl, Laurence (2003) Expression, purification and preliminary X-ray analysis of the BRCT domain from Rhp9/Crb2. Acta Crystallographica Section D: Biological Crystallography, 59 (Pt 7). 1230-1233.. ISSN 0907-4449

Prodromou, Chrisostomos, Panaretou, Barry, Chohan, Shahzad, Siligardi, Giuliano, O'Brien, Ronan, Ladbury, John E, Roe, S Mark, Piper, Peter W and Pearl, Laurence H (2000) The ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the N-terminal domains. EMBO Journal, 19 (16). pp. 4383-92. ISSN 0261-4189

Roe, S Mark, Prodromou, Chrisostomos, O'Brien, Ronan, Ladbury, John E, Piper, Peter W and Pearl, Laurence H (1999) Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin. Journal of Medicinal Chemistry, 42 (2). pp. 260-266. ISSN 0022-2623

Panaretou, Barry, Prodromou, Chrisostomos, Roe, S Mark, O'Brien, Ronan, Ladbury, John E, Piper, Peter W and Pearl, Laurence H (1998) ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo. EMBO Journal, 17 (16). pp. 4829-4836. ISSN 0261-4189

Prodromou, Chrisostomos, Roe, S Mark, O'Brien, Ronan, Ladbury, John E, Piper, Peter W and Pearl, Laurence H (1997) Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone. Cell, 90 (1). pp. 65-75. ISSN 0092-8674

Prodromou, Chrisostomos, Roe, S Mark, Piper, Peter W and Pearl, Laurence H (1997) A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone. Nature Structural Biology, 4 (6). pp. 477-482. ISSN 1072-8368

Conference or Workshop Item

Walliser, C, Retlich, M, Wollny, C, Harris, R, Everett, K L, Josephs, M B, Roe, S M, Vatter, P, Christow, C, Rodrigues-Lima, F, Pearl, L H, Driscoll, P C, Katan, M, Gierschik, P and Bunney, T D (2008) Rac2 regulates its effector phospholipase C-gamma 2 through interaction with a split PH domain. In: 49th Annual Meeting German-Society-for-Experimental-and-Clinical-Pharmacology-and-Toxicology, Mainz, GERMANY.