Photo of Guy Richardson

Guy Richardson
Professor of Neuroscience 'Royal Society Wolfson Research Merit Award holder' (Neuroscience)
E:
T: +44 (0)1273 678717 or +44 (0)1273 678397


Research

 The Richardson lab is currently working on (i) the tectorial membrane, an extracellular matrix unique to the inner ear, (ii) receptor-like proteins that are associated with the mechanosensory hair bundles of the inner ear and (iii) the development of methods for protecting sensory hair cells from the ototoxic effects of aminoglycoside antibiotics. The work currently includes (a) developing a novel in vitro model system to discover how deafness causing mutations in Tecta, one major non-collagneous glycoproteins of the tectorial membrane, influence its targeting, secretion and self assembly, (b) investigating whether the hair-bundle membrane proteins Ptprq (a receptor-like inositol lipid phosphatase) and Vlgr1 (a G-protein coupled receptor) are mechanically activated, and (c) elucidating the cellular pathways that allow hair cells to repair repair the damage caused by short-term exposure to aminoglycoside antibiotics. Please see the Richardson lab home page for more detail (http://www.sussex.ac.uk/lifesci/richardsonlab/).