Photo of Guy Richardson

Guy Richardson
Professor of Neuroscience 'Royal Society Wolfson Research Merit Award holder' (Neuroscience)
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T: +44 (0)1273 678717 or +44 (0)1273 678397


Selected publications

Article

Kenyon, Emma J, Kirkwood, Nerissa K, Kitcher, Siân R, O'Reilly, Molly, Derudas, Marco, Cantillon, Daire M, Goodyear, Richard J, Secker, Abigail, Baxendale, Sarah, Bull, James C, Waddell, Simon J, Whitfield, Tanya T, Ward, Simon E, Kros, Corné J and Richardson, Guy P (2017) Identification of ion-channel modulators that protect against aminoglycoside-induced hair cell death. Journal of Clinical Investigation Insight, 2 (24). ISSN 2379-3708

Kenyon, Emma J, Kirkwood, Nerissa K, Kitcher, Siân R, O'Reilly, Molly, Derudas, Marco, Cantillon, Daire M, Goodyear, Richard J, Secker, Abigail, Baxendale, Sarah, Bulley, James C, Waddell, Simon J, Whitfield, Tanya T, Ward, Simon E, Kros, Corné J and Richardson, Guy P (2017) Identification of ion-channel modulators that protect against aminoglycoside-induced hair-cell death. Journal of Clinical Investigation Insight, 2 (24). ISSN 2379-3708

Corns, Laura F, Jeng, Jing-Yi, Richardson, Guy P, Kros, Corné J and Marcotti, Walter (2017) TMC2 modifies permeation properties of the mechanoelectrical transducer channel in early postnatal mouse cochlear outer hair cells. Frontiers in Molecular Neuroscience, 10. ISSN 1662-5099

Chavez, Gabriela G, Taylor, Gabriella, Garaliene, Jekaterina, Richardson, Guy P and Korneev, Sergei A (2017) The temporal expression profile of a Nos3-related natural antisense RNA in the brain suggests a possible role in neurogenesis. Nitric Oxide, 71. pp. 27-31. ISSN 1089-8603

Goodyear, Richard J, Lu, Xiaowei, Deans, Michael R and Richardson, Guy P (2017) A tectorin-based matrix and planar-cell-polarity genes are required for normal collagen-fibril orientation in the developing tectorial membrane. Development, 144. pp. 3978-3989. ISSN 0950-1991

Kirkwood, Nerissa K, O'Reilly, Molly, Derudas, Marco, Kenyon, Emma J, Huckvale, Rosemary, van Netten, Sietse M, Ward, Simon E, Richardson, Guy P and Kros, Corné Kros (2017) d-Tubocurarine and berbamine: alkaloids that are permeant blockers of the hair cell's mechano-electrical transducer channel and protect from aminoglycoside toxicity. Frontiers in Cellular Neuroscience, 11. ISSN 1662-5102

Quadros, Rolen M, Miura, Hiromi, Harms, Donald W, Akatsuka, Hisako, Sato, Takehito, Aida, Tomomi, Redder, Ronald, Richardson, Guy P, Inagaki, Yutaka, Sakai, Daisuke, Buckley, Shannon, Seshacharyulu, Parthasarathy, Batra, Surinder K, Behlke, Mark A, Zeiner, Sarah A, Jacobi, Ashley M, Izu, Yayoi, Thorenson, Wallace B, Urness, Lisa D, Mansour, Suzanne L, Ohtsuka, Masato and Gurumurthy, Channabasavaiah B (2017) Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins. Genome Biology, 18 (92). ISSN 1474-760X

Majumder, Paromita, Moore, Paulette A, Richardson, Guy P and Gale, Jonathan E (2017) Protecting mammalian hair cells from aminoglycoside-toxicity: assessing phenoxybenzamine’s potential. Frontiers in Cellular Neuroscience, 11 (94). pp. 1-11. ISSN 1662-5102

Shaya, Oren, Binshtok, Udi, Hersh, Micha, Rivken, Dmitri, Weinreb, Sheila, Amir-Siberstein, Liat, Khamaisi, Bassma, Oppenheim, Olya, Desai, Ravi A, Goodyear, Richard J, Richardson, Guy P, Cheng, Christopher S and Sprinzak, David (2017) Cell-cell contact area affects Notch signaling and Notch-dependent patterning. Developmental Cell, 40 (5). pp. 505-511. ISSN 1534-5807

Marcotti, Walter, Corns, Laura F, Goodyear, Richard J, Rzadzinska, Agnieszka K, Avraham, Karen B, Steel, Karen P, Richardson, Guy P and Kros, Corné J (2016) The acquisition of mechano-electrical transducer current adaptation in auditory hair cells requires myosin VI. Journal of Physiology, 594 (13). pp. 3667-3681. ISSN 0022-3751

Korneev, Sergei A, Maconochie, Mark, Naskar, Souvik, Korneeva, Elena I, Richardson, Guy P and O'Shea, Michael (2015) A novel long non-coding natural antisense RNA is a negative regulator of Nos1 gene expression. Scientific Reports, 5. p. 11815. ISSN 2045-2322

Marcotti, Walter, Corns, Laura F, Desmonds, Terri, Kirkwood, Nerissa K, Richardson, Guy P and Kros, Corné J (2014) Transduction without tip links in cochlear hair cells is mediated by ion channels with permeation properties distinct from those of the mechano-electrical transducer channel. Journal of Neuroscience, 34 (16). pp. 5505-5514. ISSN 0270-6474

Legan, Kevin, Goodyear, Richard, Morin, Matias, Mencia, Angeles, Pollard, Hilary, Olavarrieta, Leticia, Korchagina, Julia Jurievna, Modiamo-Hoybjor, Silvia, Mayo, Fernando, Moreno, Felipe, Moreno-Pelayo, Miguel-Angel and Richardson, Guy (2013) Three deaf mice: mouse models for TECTA-based human hereditary deafness reveal domain-specific structural phenotypes in the tectorial membrane. Human Molecular Genetics, 23 (10). pp. 2551-2568. ISSN 0964-6906

Goodyear, Richard J, Jones, Sherri M, Sharifi, Louise, Forge, Andy and Richardson, Guy P (2012) Hair bundle defects and loss of function in the vestibular end organs of mice lacking the receptor-like inositol lipid phosphatase PTPRQ. Journal of Neuroscience, 32 (8). pp. 2762-72. ISSN 0270-6474

Lukashkin, Andrei N, Legan, P Kevin, Weddell, Thomas D, Lukashkina, Victoria A, Goodyear, Richard J, Welstead, Lindsey J, Petit, Christine, Russell, Ian J and Richardson, Guy P (2012) A mouse model for human deafness DFNB22 reveals that hearing impairment is due to a loss of inner hair cell stimulation. Proceedings of the National Academy of Sciences of the United States of America, 109 (47). pp. 19351-19356. ISSN 1091-6490

Ghaffari, Roozbeh, Aranyosi, Alexander J, Richardson, Guy P and Freeman, Dennis M (2010) Tectorial membrane travelling waves underlie abnormal hearing in Tectb mutant mice. Nature Communications, 1 (7). p. 96. ISSN 2041-1723

Michalski, Nicolas, Michel, Vincent, Caberlotto, Elisa, Lefèvre, Gaelle M, Van Aken, Alexander F J, Tinevez, Jean-Yves, Bizard, Emilie, Houbron, Christophe, Weil, Dominique, Hardelin, Jean-Pierre, Richardson, Guy P, Kros, Corné J, Martin, Pascal and Petit, Christine (2009) Harmonin-b, an actin-binding scaffold protein, is involved in the adaptation of mechanoelectrical transduction by sensory hair cells. Pflügers Archiv European Journal of Physiology, 459 (1). pp. 115-130. ISSN 0031-6768

Van Aken, Alexander F J, Atiba-Davies, Margaret, Marcotti, Walter, Goodyear, Richard J, Bryant, Jane E, Richardson, Guy P, Noben-Trauth, Konrad and Kros, Corné J (2008) TRPML3 mutations cause impaired mechano-electrical transduction and depolarization by an inward-rectifier cation current in auditory hair cells of varitint-waddler mice. Journal of Physiology, 586 (22). pp. 5403-5418. ISSN 0022-3751

Verpy, Elisabeth, Weil, Dominique, Leibovici, Michel, Goodyear, Richard J, Hamard, Ghislaine, Houdon, Carine, Lefèvre, Gaelle M, Hardelin, Jean-Pierre, Richardson, Guy P, Avan, Paul and Petit, Christine (2008) Stereocilin-deficient mice reveal the origin of cochlear waveform distortions. Nature, 456 (7219). pp. 255-258. ISSN 0028-0836

Nie, Liping, Zhu, Jun, Gratton, Michael Anne, Liao, Amy, Mu, Karen J, Nonner, Wolfgang, Richardson, Guy P and Yamoah, Ebenezer N (2008) Molecular identity and functional properties of a novel T-type Ca2+ channel cloned from the sensory epithelia of the mouse inner ear. Journal of Neurophysiology, 100 (4). pp. 2287-2299. ISSN 0022-3077

Moreno-Pelayo, Miguel Ángel, Goodyear, Richard J, Mencía, Ángeles, Modamio-Høybjør, Silvia, Legan, P Kevin, Olavarrieta, Leticia, Moreno, Felipe and Richardson, Guy P (2008) Characterization of a spontaneous, recessive, missense mutation arising in the Tecta gene. Journal of the Association for Research in Otolaryngology, 9 (2). pp. 202-214. ISSN 1525-3961

Leibovici, Michel, Verpy, Elisabeth, Goodyear, Richard J, Zwaenepoel, Ingrid, Blanchard, Stéphane, Lainé, Sophie, Richardson, Guy P and Petit, Christine (2005) Initial characterization of kinocilin, a protein of the hair cell kinocilium. Hearing Research, 203 (1-2). pp. 144-153. ISSN 0378-5955

Boëda, Batiste, El-Amraoui, Aziz, Bahloul, Amel, Goodyear, Richard, Daviet, Laurent, Blanchard, Stéphane, Perfettini, Isabelle, Fath, Karl R, Shorte, Spencer, Reiners, Jan, Houdusse, Anne, Legrain, Pierre, Wolfrum, Uwe, Richardson, Guy and Petit, Christine (2002) Myosin VIIa, harmonin and cadherin23, three Usher I gene products cooperate to shape the sensory hair bundle. EMBO Journal, 21 (24). 6689 - 6699. ISSN 0261-4189

Legan, P Kevin, Lukashkina, Victoria A, Kössl, Manfred, Goodyear, Richard J, Russell, Ian J and Richardson, Guy P (2000) A targeted deletion in alpha-tectorin reveals that the tectorial membrane is required for the gain and timing of cochlear feedback. Neuron, 28 (1). pp. 273-285. ISSN 08966273