photo of Timothy Chevassut

Prof Timothy Chevassut

Post:Reader (Honorary Consultant) in Haematology (Clinical and Experimental Medicine)
Location:MEDICAL RESEARCH BUILDING MRB-108
Email:bsms1678@sussex.ac.uk

Telephone numbers
Internal:3232
UK:01273 873232
International:+44 1273 873232

Research expertise:
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Biography

Dr Chevassut is both a clinical haematologist and basic scientist.  He studied medicine and molecular biology at Oxford before spending a research fellowship at Harvard where he conducted research on embryonic stem cells and DNA methylation.  He subsequently completed a PhD at Edinburgh working on RNA interference before returning to medicine and completing specialist training in clinical haematology.  In 2007 he was appointed to the post of Senior Lecturer at Brighton and Sussex Medical School.  He also practices as an honorary Consultant Haematologist at the Royal Sussex County Hospital.

Dr Chevassut’s clinical area of interest is blood cancers with a particular focus on acute myeloid leukaemia (AML) and the myelodysplastic syndromes (MDS).  These are related diseases of the blood for which we now have a remarkable understanding of the molecular basis of disease, yet the treatment options remain very limited, particularly in the elderly where stem cell transplantation is often not possible.  Dr Chevassut’s recent work has focussed on one particular gene mutation that carries a particularly poor prognosis in AML, namely the DNA methyltransferase gene DNMT3A.  His laboratory has shown that mutations in DNMT3A often initiate leukaemia and can be detected rapidly using PCR to improve diagnosis, and more importantly, can be targeted effectively using a novel strategy called a bromodomain inhibition.

 

Posts: Senior Lecturer in Haematology and Honorary Consultant (BSUH NHS Trust)

             Director of Clinical Academic Training (Brighton and Sussex Medical School)

 

Qualifications: BMBCh MA – Oxford University, 1993

                          MPH – Harvard University, 1998

                          PhD – Edinburgh University, 2006

 

Fellowships: Royal College of Pathologists (2010)

                       Royal College of Physicians (2011)

 

Memberships: British Society of Haematology

                          NCRI Myelodysplasia Subgroup

 

Location: BSMS Medical Research Building (UoS)

Email: t.chevassut@bsms.ac.uk

Telephone: 1273-873232 (extension 3232)

 

Research expertise: clinical haematology, acute myeloid leukaemia, myelodysplastic syndromes, stem cells, DNA methylation, epigenetics, targeted therapies, cancer trials