Photo of Alan Lehmann

Alan Lehmann
Research Professor, Molecular Genetics (Genome Damage and Stability)
T: +44 (0)1273 678120

Selected publications


Calmels, Nadege, Botta, Elena, Jia, Nan, Fawcett, Heather, Nardo, Tiziana, Nakazawa, Yuka, Lanzafame, Manuela, Moriwaki, Shinichi, Sugita, Katsuo, Kubota, Masaya, Orbinger, Cathy, Spitz, Marie-Aude, Stefanini, Miria, Laugel, Vincent, Orioli, Donata, Ogi, Tomoo and Lehmann, Alan Robert (2018) Functional and clinical relevance of novel mutations in a large cohort of patients with Cockayne syndrome. Journal of Medical Genetics, 55 (5). pp. 329-343. ISSN 0022-2593

Lehmann, Alan (2017) Xeroderma pigmentosum is a definite cause of Huntington's disease-like syndrome. Annals of Clinical and Translational Neurology, 5 (1). pp. 102-108. ISSN 2328-9503

Bertoletti, Federica, Cea, Valentina, Liang, Chih-Chao, Lanati, Taiba, Maffia, Antonio, Avarello, Mario D M, Cipolla, Lina, Lehmann, Alan R, Cohn, Martin A and Sabbioneda, Simone (2017) Phosphorylation regulates human polη stability and damage bypass throughout the cell cycle. Nucleic Acids Research, 45 (16). pp. 9441-9454. ISSN 1362-4962

Alt, Aaron, Dang, Hung Q, Wells, Owen S, Polo, Luis M, Smith, Matt A, McGregor, Grant A, Welte, Thomas, Lehmann, Alan R, Pearl, Laurence H, Murray, Johanne M and Oliver, Antony W (2017) Specialized interfaces of Smc5/6 control hinge stability and DNA association. Nature Communications, 8. p. 14011. ISSN 2041-1723

van der Crabben, Saskia N, Hennus, Marije P, McGregor, Grant, Ritter, Deborah I, Nagamani, Sandesh C S, Wells, Owen S, Harakalova, Magdalena, Chinn, Ivan K, Alt, Aaron, Vondrova, Lucie, Hochstenbach, Ron, van Montfrans, Joris M, Terheggen-Lagro, Suzanne W, van Lieshout, Stef, van Roosmalen, Markus J, Renkens, Ivo, Duran, Karen, Nijman, Isaac J, Kloosterman, Wigard P, Hennekam, Eric, Orange, Jordan S, van Hasselt, Peter M, Wheeler, David A, Palecek, Jan J, Lehmann, Alan R, Oliver, Antony W, Pearl, Laurence H, Plon, Sharon E, Murray, Johanne M and van Haaften, Gijs (2016) Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease. Journal of Clinical Investigation, 126 (8). pp. 2881-2892. ISSN 0021-9738

Sethi, Mieran, Hague, Shaheen, Fawcett, Heather, Wing, Jonathan F, Chandler, Natalie, Mohammed, Shehla, Frayling, Ian M, Norris, Paul G, McGibbon, David, Young, Antony R, Sarkany, Robert P E, Lehmann, Alan R and Fassihi, Hiva (2016) [Letter] A distinct genotype of XP complementation group A: surprisingly mild phenotype highly prevalent in Northern India/ Pakistan/ Afghanistan. Journal Of Investigative Dermatology, 136 (4). pp. 869-872. ISSN 0022-202X

Zabrady, Katerina, Adamus, Marek, Vondrova, Lucie, Liao, Chunyan, Skoupilova, Hana, Novakova, Marketa, Jurcisinova, Lenka, Alt, Aaron, Oliver, Antony W, Lehmann, Alan R and Palecek, Jan J (2016) Chromatin association of the SMC5/6 complex is dependent on binding of its NSE3 subunit to DNA. Nucleic Acids Research, 44 (3). pp. 1064-1079. ISSN 1362-4962

Fassihi, Hiva, Sethi, Mieran, Fawcett, Heather, Wing, Jonathan, Chandler, Natalie, Mohammed, Shehla, Craythorne, Emma, Morley, Ana M S, Lim, Rongxuan, Turner, Sally, Henshaw, Tanya, Garrood, Isabel, Giunti, Paola, Hedderly, Tammy, Abiona, Adesoji, Naik, Harsha, Harrop, Gemma, McGibbon, David, Jaspers, Nicolaas G J, Botta, Elena, Nardo, Tiziana, Stefanini, Miria, Young, Antony R, Sarkany, Robert P E and Lehmann, Alan R (2016) Deep phenotyping of 89 xeroderma pigmentosum patients reveals unexpected heterogeneity dependent on the precise molecular defect. Proceedings of the National Academy of Sciences, 113 (9). E1236-E1245. ISSN 1091-6490

Kozakova, Lucie, Vondrova, Lucie, Stejskal, Karel, Charalabous, Panagoula, Kolesar, Peter, Lehmann, Alan R, Uldrijan, Stjepan, Sanderson, Christopher M, Zdrahal, Zbynek and Palecek, Jan J (2015) The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex. Cell Cycle, 14 (6). pp. 920-930. ISSN 1538-4101

Arseni, Lavinia, Lanzafame, Manuela, Compe, Emmanuel, Fortugno, Paola, Afonso-Barroso, Antonio, Peverali, Fiorenzo A, Lehmann, Alan R, Zambruno, Giovanna, Egly, Jean-Marc, Stefanini, Miria and Orioli, Donata (2015) TFIIH-dependent MMP-1 overexpression in trichothiodystrophy leads to extracellular matrix alterations in patient skin. Proceedings of the National Academy of Sciences, 112 (5). pp. 1499-1504. ISSN 1091-6490

Guo, Chaowan, Nakazawa, Yuka, Woodbine, Lisa, Björkman, Andrea, Shimada, Mayuko, Fawcett, Heather, Jia, Nan, Ohyama, Kaname, Li, Tao-Sheng, Nagayama, Yuji, Mitsutake, Norisato, Pan-Hammarström, Qiang, Gennery, Andrew R, Lehmann, Alan R, Jeggo, Penny A and Ogi, Tomoo (2015) XRCC4 deficiency in human subjects causes a marked neurological phenotype but no overt immunodeficiency. Journal of Allergy and Clinical Immunology, 136 (4). pp. 1007-1017. ISSN 0091-6749

Zheng, Christina L, Wang, Nicholas J, Chung, Jongsuk, Moslehi, Homayoun, Sanborn, J Zachary, Hur, Joseph S, Collison, Eric A, Vemula, Swapna S, Naujokas, Agne, Chiotti, Kami E, Cheng, Jeffrey B, Fassihi, Hiva, Blumberg, Andrew J, Bailey, Celeste V, Fudem, Gary M, Mihm, Frederick G, Cunningham, Bati B, Neuhaus, Isaac M, Liao, Wilson, Oh, Dennis H, Cleaver, James E, LeBoit, Philip E, Costello, Joseph F, Lehmann, Alan, Gray, Joe W, Spellman, Paul T, Aaron, Sarah T, Huh, Nam, Purdom, Elizabeth and Cho, Raymond J (2014) Transcription restores DNA repair to heterochromatin, determining regional mutation rates in cancer genomes. Cell Reports, 9 (4). pp. 1228-1234. ISSN 2211-1247

Baple, Emma L, Chambers, Helen, Cross, Harold E, Fawcett, Heather, Nakazawa, Yuka, Chioza, Barry A, Harlalka, Gaurav V, Mansour, Sahar, Sreekantan-Nair, Ajith, Patton, Michael A, Muggenthaler, Martina, Rich, Phillip, Wagner, Karin, Coblentz, Roselyn, Stein, Constance K, Last, James I, Taylor, A Malcolm R, Jackson, Andrew P, Ogi, Tomoo, Lehmann, Alan R, Green, Catherine M and Crosby, Andrew H (2014) Hypomorphic PCNA mutation underlies a novel human DNA repair disorder. Journal of Clinical Investigation, 124 (7). pp. 3137-3146. ISSN 0021-9738

Sethi, Mieran, Lehmann, Alan R and Fassih, Hiva (2013) Xeroderma pigmentosum: a multidisciplinary approach. European Medical Journal Dermatol. pp. 54-63. ISSN 1472-0213

Niimi, Atsuko, Chambers, Anna L, Downs, Jessica A and Lehmann, Alan R (2012) A role for chromatin remodellers in replication of damaged DNA. Nucleic Acids Research, 40 (15). pp. 7393-7403. ISSN 0305-1048

Nakazawa, Yuka, Sasaki, Kensaku, Mitsutake, Norisato, Matsuse, Michiko, Shimada, Mayuko, Nardo, Tiziana, Takahashi, Yoshito, Ohyama, Kaname Ohyama, Ito, Kosei, Mishima, Hiroyuki, Nomura, Masayo, Kinoshita, Akira, Ono, Shinji, Takenaka, Katsuya, Masuyama, Ritsuko, Kudo, Takashi, Slor, Hanoch, Utani, Atsushi, Tateishi, Satoshi, Yamashita, Shunichi, Stefanini, Miria, Lehmann, Alan R, Yoshiura, Koh-ichiro and Ogi, Tomoo (2012) Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair. Nature Genetics, 44 (5). pp. 586-592. ISSN 1061-4036

Lehmann, Alan R (2012) DNA repair, DNA replication and human disorders: A personal journey. DNA Repair, 11 (4). pp. 328-334. ISSN 1568-7864

Sale, Julian E, Lehmann, Alan R and Woodgate, Roger (2012) Y-family DNA polymerases and their role in tolerance of cellular DNA damage. Nature Reviews Molecular Cell Biology, 13. pp. 141-152. ISSN 1471-0072

Lehmann, Alan R (2011) Ubiquitin-family modifications in the replication of DNA damage. FEBS Letters, 585 (18). pp. 2772-2779. ISSN 0014-5793

Göhler, Thomas, Sabbioneda, Simone, Green, Catherine M and Lehmann, Alan R (2011) ATR-mediated phosphorylation of DNA polymerase η is needed for efficient recovery from UV damage. Journal of Cell Biology, 192 (2). pp. 219-227. ISSN 0021-9525

Lehmann, Alan R, McGibbon, David and Stefanini, Miria (2011) Xeroderma Pigmentosum. Orphanet Journal of Rare Diseases, 6. ISSN 1750-1172

Mari, Pierre-Olivier, Verbiest, Vincent, Sabbioneda, Simone, Gourdin, Audrey M, Wijgers, Nils, Dinant, Christoffel, Lehmann, Alan R, Vermeulen, Wim and Giglia-Mari, Guiseppina (2010) Influence of the live cell DNA marker DRAQ5 on chromatin-associated processes. DNA Repair, 9 (7). pp. 848-855. ISSN 1568-7864

Coulon, Stéphane, Ramasubramanyan, Sharada, Alies, Carole, Philippin, Gaëlle, Lehmann, Alan and Fuchs, Robert P (2010) Rad8Rad5/Mms2–Ubc13 ubiquitin ligase complex controls translesion synthesis in fission yeast. EMBO Journal, 29 (12). pp. 2048-2058. ISSN 0261-4189

Nakazawa, Yuka, Yamashita, Shunichi, Lehmann, Alan R and Ogi, Tomoo (2010) A semi-automated non-radiactive system for measuring recovery of RNA synthesis and unscheduled DNA synthesis using ethynyluracil derivatives. DNA Repair, 9 (5). pp. 506-516. ISSN 1568-7864

Ogi, Tomoo, Limsirichaikul, Siripan, Overmeer, René M, Volker, Marcel, Takenaka, Katsuya, Cloney, Ross, Nakazawa, Yuka, Niimi, Atsuko, Miki, Yoshio, Japers, Nicolaas G, Mullenders., Leon H F, Yamashita, Shunichi, Fousteri, Maria I and Lehmann, Alan R (2010) Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells. Molecular Cell, 37 (5). pp. 714-727. ISSN 1097-2765

Laugel, V, Dalloz, C, Durand, M, Sauvanaud, F, Kristensen, U, Vincent, M C, Pasquier, L, Odent, S, Cormier-Daire, V, Gener, B, Tobias, E S, Tolmie, J L, Martin-Coignard, D, Drouin-Garraud, V, Heron, D, Journel, H, Raffo, E, Vigneron, J, Lyonnet, S, Murday, V, Gubser-Mercati, D, Funalot, B, Brueton, L, Sanchez del Polo, J, Muñoz, E, Gennery, A R, Salih, M, Noruzina, M, Prescott, K, Ramos, L, Stark, Z, Fieggen, K, Chabrol, B, Sarda, P, Edery, P, Bloch-Zupan, A, Fawcett, F, Pham, D, Egly, J M, Lehmann, A R, Sarasin, A and Dollfus, H (2010) Mutation Update for the CSB/ERCC6 and CSA/ERCC8 Genes Involved in Cockayne Syndrome. Human Mutation, 31 (2). pp. 113-126. ISSN 1059-7794

Laugel, V, Dalloz, C, Durand, M, Sauvanaud, F, Kristensen, U, Vincent, M C, Pasquier, L, Odent, S, Cormier-Daire, V, Gener, B, Tobias, E S, Tolmie, J L, Martin-Coignard, D, Drouin-Garraud, V, Heron, D, Journel, H, Raffo, E, Vigneron, J, Lyonnet, S, Murday, V, Gubser-Mercati, D, Funalot, B, Sanchez del Pozo, J, Muñoz, E, Gennery, A R, Salih, M, Noruzinia, M, Prescott, K, Ramos, L, Stark, Z, Fieggen, K, Chabrol, B, Sarda, P, Edery, P, Bloch-Zupan, A, Fawcett, H, Pham, D, Egly, J M, Lehmann, A R, Sarasin, A and Dollfus, H (2010) Mutation update for the CSB/ERCC6 and CSA/ERCC8 genes involved in Cockayne syndrome. Human Mutation, 31 (2). pp. 113-126. ISSN 1059-7794

Forsythe, Elizabeth, Wild, Ruth, Sellick, Gabrielle, Houlston, Richard S., Lehmann, Alan R. and Wakeling, Emma (2009) A novel DNA repair disorder with thrombocytopenia, nephrosis and features overlapping Cockayne syndrome. American Journal of Medical Genetics Part A, 149A (10). pp. 2075-2079. ISSN 1552-4825

Limsirichaikul, Siripan, Niimi, Atsuko, Fawcett, Heather, Lehmann, Alan, Yamashita, Shunichi and Ogi, Tomoo (2009) A rapid non-radioactive technique for measurement of repair synthesis in primary human fibroblasts by incorporation of Ethynyl deoxyuridine (EdU). Nucleic Acids Research, 37 (4). ISSN 0305-1048

Sabbioneda, Simone, Gourdin, Audrey M, Green, Catherine M, Zotter, Angelika, Giglia-Mari, Giuseppina, Houtsmuller, Adriaan, Vermeulen, Wim and Lehmann, Alan R (2008) Effect of proliferating cell nuclear antigen ubiquitination and chromatin structure on the dynamic properties of the Y-family DNA polymerases. Molecular Biology of the Cell, 19 (12). pp. 5193-5202. ISSN 1939-4586

Lehmann, Alan R. (2008) XPD structure reveals its secrets. DNA Repair, 7 (11). pp. 1912-1915. ISSN 1568-7864

Niimi, Atsuko, Brown, Stephanie, Sabbioneda, Simone, Kannouche, Patricia L., Scott, Andrew, Yasui, Akira, Green, Catherine M. and Lehmann, Alan R. (2008) Regulation of proliferating cell nuclear antigen ubiquitination in mammalian cells. Proceedings of the National Academy of Sciences, 105 (42). pp. 16125-16130. ISSN 0027-8424

Anttinen, Anu, Koulu, Leena, Nikoskelainen, Eeva, Portin,, Raija, Kurki, Timo, Erkinjuntti,, Matti, Jaspers, Nicolaas G J, Raams, Anja, Green, Michael H L, Lehmann, Alan R, Wing, Jonathan F, Arlett, Colin F and Marttila, Reijo J (2008) Neurological symptoms and natural course of xeroderma pigmentosum. Brain, 131 (8). pp. 1979-1989. ISSN 0006-8950

Taylor, Elaine M, Copsey, Alice C, Hudson, Jessica J, Vidot, Susanne and Lehmann, Alan R (2008) Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex. Molecular and Cellular Biology, 28 (4). pp. 1197-1206. ISSN 0270-7306

Botta, Elena, Offman, Judith Muriel, Nardo, Tiziana, Ricotti, Roberta, Zambruno, Giovanna, Sansone, Daniela, Balestri, Paolo, Raams, Anja, Kleijer, Wim J., Jaspers, Nicolaas G.J., Sarasin, Alain, Lehmann, Alan R. and Stefanini, Miria (2007) Mutations in the C7orf11 (TTDN1) gene in six nonphotosensitive Trichothiodystrophy patients: no obvious genotype–phenotype relationships. Human Mutation, 28 (1). pp. 92-96. ISSN 1059-7794

Lehmann, Alan R. and Fuchs, Robert P. (2006) Gaps and forks in DNA replication: Rediscovering old models. DNA Repair, 5 (12). pp. 1495-1498. ISSN 1568-7864

Oh, Kyu-Seon, Khan, Sikandar G., Jaspers, N.G.J., Raams, Anja, Ueda, Takahiro, Lehmann, Alan, Friedmann, Peter S., Emmert, Steffen, Gratchev, Alexi, Lachlan, Katherine, Lucassan, Anneke, Baker, Carl C. and Kraemer, Kenneth H. (2006) Phenotypic Heterogeneity in the XPB DNA Helicase Gene (ERCC3): Xeroderma Pigmentosum Without and With Cockayne Syndrome. Human Mutation, 27 (11). pp. 1092-1103. ISSN 1059-7794

Lehmann, Alan R. (2006) Translesion synthesis in mammalian cells. Experimental Cell Research, 312 (14). pp. 2673-2676. ISSN 0014-4827

Friedberg, Errol C., Aguilera, Andres, Gellert, Martin, Hanawalt, Phillip C., Hays, John B., Lehmann, Alan, Lindahl, Thomas, Lowndes, Noel, Sarasin, Alain and Wood, Richard D. (2006) DNA repair: from molecular mechanism to human disease. DNA Repair, 5 (8). pp. 986-996. ISSN 1568-7864

Frampton, Jonathan, Irmisch, Anja, Green, Catherine M, Neiss, Andrea, Trickey, Michelle, Ulrich, Helle D, Furuya, Kanji, Watts, Felicity, Carr, Antony M and Lehmann, Alan R (2006) Postreplication Repair and PCNA Modification in Schizosaccharomyces pombe. Molecular Biology of the Cell, 17 (7). pp. 2976-2985. ISSN 1059-1524

Arlett, C. F., Plowman, P. N., Rogers, P. B., Parris, C. N., Abbaszadeh, F., Green, M. H. L., McMillan, T.J., Bush, C., Foray, N. and Lehmann, A. R. (2006) Clinical and cellular ionizing radiation sensitivity in a patient with xeroderma pigmentosum. British Journal of Radiology, 79 (942). pp. 510-517. ISSN 0007-1285

Lehmann, Alan (2006) Ecallantide (Dyax/Genzyme). Current Opinion in Investigational Drugs, 7 (3). pp. 282-90. ISSN 1472-4472

Palecek, J., Vidot, Susanne, Feng, M., Doherty, A. J. and Lehmann, A. R. (2006) The SMC5-6 DNA repair complex: bridging of the SMC5-6 heads by the Kleisin, NSE4, and non-Kleisin subunits. Journal of Biological Chemistry, 2006 D (48). pp. 36952-36959. ISSN 0021-9258

Theron, Therina, Fousteri, Maria I., Volker, Marcel, Harries, Lorna W., Botta, Elena, Stefanini, Miria, Fujimoto, Mitsuo, Andressoo, Jaan-Olle, Mitchell, Jay, Jaspers, Nicolaas G. J., McDaniel, Lisa D., Mullenders, Leon H. and Lehmann, Alan R. (2005) Transcription-associated breaks in Xeroderma Pigmentosum group D cells from patients with combined features of Xeroderma Pigmentosum and Cockayne Syndrome. Molecular and Cellular Biology, 25 (18). pp. 8368-8378. ISSN 0270-7306

Lehmann, Alan R. (2005) The role of SMC proteins in the responses to DNA damage. DNA Repair, 4 (3). pp. 309-314. ISSN 1568-7864

Sergeant, John, Taylor, Elaine, Palecek, Jan, Fousteri, Maria, Andrews, Emily, Sweeney, Sara, Shinagawa, Hideo, Watts, Felicity and Lehmann, Alan (2005) Composition and Architecture of the Schizosaccharomyces pombe Rad18 (Smc5-6) Complex. Molecular and Cellular Biology, 25 (1). pp. 172-184. ISSN 0270-7306

Andrews, Emily A, Palecek, Jan, Sergeant, John, Taylor, Elaine, Lehmann, Alan R and Watts, Felicity Z (2005) Nse2, a component of the Smc5-6 complex, is a SUMO ligase required for the response to DNA damage. Molecular and Cellular Biology, 25 (1). pp. 185-196. ISSN 0270-7306

Ogi, Tomoo, Kannouche, Patricia and Lehmann, Alan (2005) Localisation of human Y-family DNA polymerase κ: relationship to PCNA foci. Journal of Cell Science, 118 (1). pp. 129-136. ISSN 0021-9533

Albertella, Mark R., Green, Catherine M., Lehmann, Alan R. and O'Connor, Mark J. (2005) A Role for Polymerase η in the Cellular Tolerance to Cisplatin-Induced Damage. Cancer Research, 65 (21). pp. 9799-806. ISSN 0008-5472

Fujimoto, Mitsuo, Leech, Suzanne N., Theron, Therina, Mori, Masato, Fawcett, Heather, Botta, Elena, Nozaki, Yasuyuki, Yamagata, Takanori, Moriwaki, Shin-Ichi, Stefanini, Miria, Momoi, Mariko Y., Nakagawa, Hidemi, Shuster, Sam, Moss, Celia and Lehmann, Alan R. (2005) Two New XPD Patients Compound Heterozygous for the Same Mutation Demonstrate Diverse Clinical Features. Journal of Investigative Dermatology, 125 (1). pp. 86-92. ISSN 0022-202x

Bienko, M., Green, C. M., Crosetto, N., Rudolf, F., Zapart, G., Coull, B., Kannouche, P., Wider, G., Peter, M., Lehmann, Alan, Hofmann, K. and Dikic, I. (2005) Ubiquitin-binding domains in translesion synthesis polymerases. Science, 310. ISSN 1095-9203

Kannouche, Patricia L, Wing, Jonathan and Lehmann, Alan R (2004) Interaction of Human DNA Polymerase η with Monoubiquitinated PCNA: A Possible Mechanism for the Polymerase Switch in Response to DNA Damage. Molecular Cell, 14 (4). pp. 491-500. ISSN 1097-2765

Tissier, A., Kannouche, P., Reck, M.- P., Lehmann, Alan, Fuchs, R. P. P. and Cordonnier, A. (2004) Co-localization in replication foci and interaction of human Y-family members, DNA polymerase polh and Rev1 protein. DNA Repair, 4 (3). pp. 1503-1514. ISSN 1568-7864

Kannouche, P. L., Wing, J. and Lehmann, Alan (2004) Interaction of Human DNA polymerase h with monoubiquitinated PCNA; a possible mechanism for the polymerase switch in response to DNA damage. Molecular Cell, 14 (4). pp. 491-500. ISSN 1097-2765

Taylor, Ewan R., Dornan, Edward S., Bonar, Winifred, Connolly, Julie A., McNair, Shona, Kannouche, Patricia, Lehmann, Alan and Morgan, Iain M. (2003) The fidelity of HPV16 E1/E2-mediated DNA replication. Journal of Biological Chemistry, 278 (52). pp. 52223-52230. ISSN 0021-9258

Lehmann, Alan (2003) Watson and DNA: Making a Scientific Revolution: Victor McElheny, Perseus Publishing, Cambridge, MA, ISBN 0-7382-0341-6. DNA Repair, 2 (9). pp. 1073-1074. ISSN 1568-7864

Lehmann, Alan R. (2003) Replication of Damaged DNA. Cell Cycle, 2 (4). pp. 300-302. ISSN 1538-4101

Broughton, Bernard C, Cordonnier, Agnes, Kleijer, Wim J, Jaspers, Nicolaas G J, Fawcett, Heather, Raams, Heather, Garritsen, Victor H., Stary, Anne, Avril, Marie-Francoise, Boudsocq, Francois, Masutani, Chikahide, Hanaoka, Fumio, Fuchs, Robert P, Sarasin, Alain and Lehmann, Alan R (2002) Molecular analysis of mutations in DNA polymerase η in xeroderma pigmentosum-variant patients. Proceedings of the National Academy of Sciences of the United States of America, 99 (2). pp. 815-820. ISSN 1091-6490

Kannouche, P., Fernandez De Henestrosa, A. R., Coull, B., Vidal, A. E., Gray, C., Zicha, D., Woodgate, R. and Lehmann, Alan (2002) Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells. EMBO Journal, 21 (22). pp. 6246-6256. ISSN 0261-4189

Botta, Elena, Nardo, Tiziana, Lehmann, Alan R., Egly, Jean-Marc, Pedrini, Antonia M. and Stefanini, Miria (2002) Reduced level of the repair/transcription factor TFIIH in trichothiodystrophy. Human Molecular Genetics, 11 (23). pp. 2919-2928. ISSN 0964-6906

Lehmann, Alan R (2001) Research note: xeroderma pigmentosum in the United Kingdom. Photochemistry and Photobiology, 91 (2). pp. 484-485. ISSN 0031-8655

Kannouche, Patricia, Broughton, Bernard C, Volker, Marcel, Hanaoka, Fumio, Mullenders, Leon H F and Lehmann, Alan R (2001) Domain structure, localization, and function of DNA polymerase η, defective in xeroderma pigmentosum variant cells. Genes and Development, 15 (2). pp. 158-172. ISSN 0890-9369

Viprakasit, V., Gibbons, R. J., Broughton, B. C., Tolmie, J. L., Brown, D., Lunt, P., Winter, R. M., Marinoni, S., Stefanini, M., Brueton, L., Lehmann, A. R. and Higgs, D. R. (2001) Mutations in the general transcription factor TFIIH result in beta-thalassaemia in individuals with trichothiodystrophy. Human Molecular Genetics, 10 (24). pp. 2797-2802. ISSN 0964-6906

Broughton, Bernard C., Berneburg, Mark, Fawcett, Heather, Taylor, Elaine M., Arlett, Colin F., Nardo, Tiziana, Stefanini, Miria, Menefee, Emory, Price, Vera H., Queille, Sophie, Sarasin, Alain, Bohnert, Elisabeth, Krutmann, Jean, Davidson, Rosemarie, Kraemer, Kenneth H. and Lehmann, Alan R. (2001) Two individuals with features of both xeroderma pigmentosum and trichothiodystrophy highlight the complexity of the clinical outcomes of mutations in the XPD gene. Human Molecular Genetics, 10 (22). pp. 2539-2547. ISSN 0964-6906

Broughton, Bernard C, Berneburg, Mark, Fawcett, Heather, Taylor, Elaine M, Arlett, Colin F, Nardo, Tiziana, Stefanini, Miria, Menefee, Emory, Price, Vera H, Queille, Sophie, Sarasin, Alain, Bohnert, Elisabeth, Krutmann, Jean, Davidson, Rosemarie, Kraemer, Kenneth H and Lehmann, Alan R (2001) Two individuals with features of both xeroderma pigmentosum and trichothiodystrophy highlight the complexity of the clinical outcomes of mutations in the XPD gene. Human Molecular Genetics, 10 (22). pp. 2539-2547. ISSN 0964-6906

Riballo, E, Critchlow, S E, Teo, S-H, Doherty, A J, Priestley, A, Broughton, B, Kysela, B, Beamish, H, Plowman, N, Arlett, C F, Lehmann, A R, Jackson, S P and Jeggo, P A (1999) Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient. Current Biology, 9 (13). 699 - 702. ISSN 0960-9822

Blunt, Tracy, Gell, David, Fox, Margaret, Taccioli, Guillermo E, Lehmann, Alan R, Jackson, Stephen P and Jeggo, Penny A (1996) Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the i scid mouse. Proceedings of the National Academy of Sciences of the United States of America, 93. 10285 - 10290. ISSN 0027-8424

Book Section

Lehmann, Alan R (2009) DNA damage tolerance and translesions synthesis. In: Khanna, Kum Kum and Shiloh, Yosef (eds.) The DNA damage response: implications on cancer formation and treatment. Springer, Dordrecht, pp. 209-234. ISBN 9789048125609

Lehmann, A.R. (2006) PCNA and DNA replication (II): the replication of damaged DNA. In: Lee, Hoyun (ed.) Proliferating Cell Nuclear Antigen (PCNA). Research Signpost, Trivandrum, Kerala, India, pp. 71-82. ISBN 81-308-0096-9

Lehmann, Alan (2002) Nucleotide excision repair (NER). In: Inc, John Wiley & Sons (ed.) Wiley Encyclopedia of Molecular Medicine. John Wiley & Sons Inc, Chichester, UK, pp. 2306-2309. ISBN 0471203068