Photo of Penny Jeggo

Penny Jeggo
Professorial Fellow (Genome Damage and Stability)
E:
T: +44 (0)1273 678482 or +44 (0)1273 872859


Selected publications

Article

Stiff, Tom, Casar Tena, Teresa, O'Driscoll, Mark, Jeggo, Penny A and Philipp, Melanie (2016) ATR promotes cilia signalling: links to developmental impacts. Human Molecular Genetics, 25 (8). pp. 1574-1587. ISSN 0964-6906

Baldock, Robert A, Day, Matthew, Wilkinson, Oliver J, Cloney, Ross, Jeggo, Penelope A, Oliver, Antony W, Watts, Felicity Z and Pearl, Laurence H (2015) ATM localization and heterochromatin repair depend on Direct Interaction of the 53BP1-BRCT2 domain with γH2AX. Cell Reports, 13 (10). pp. 2081-2089. ISSN 2211-1247

Woodbine, Lisa, Haines, Jackie, Coster, Margaret, Barazzuol, Lara, Ainsbury, Elizabeth, Sienkiewicz, Zenon and Jeggo, Penny (2015) The rate of X-ray-induced DNA double-strand break repair in the embryonic mouse brain is unaff ected by exposure to 50 Hz magnetic fi elds. International Journal of Radiation Biology, 91 (6). pp. 495-499. ISSN 0955-3002

Jeggo, Penny A, Pearl, Laurence H and Carr, Antony M (2015) DNA repair, genome stability and cancer: a historical perspective. Nature Reviews Cancer, 16 (1). pp. 35-42. ISSN 1474-175X

Jeggo, Penny A and Lobrich, Markus (2015) How cancer cells hijack DNA double-strand break repair pathways to gain genomic instability. Biochemical Journal, 471 (1). pp. 1-11. ISSN 0264-6021

Barazzuol, Lara, Rickett, Nicole, Ju, Limei and Jeggo, Penny A (2015) Low levels of endogenous or X-ray-induced DNA double-strand breaks activate apoptosis in adult neural stem cells. Journal of Cell Science, 128 (19). pp. 3597-3606. ISSN 0021-9533

Alagoz, Meryem, Katsuki, Yoko, Ogiwara, Hideaki, Ogi, Tomoo, Shibata, Atsushi, Kakarougkas, Andreas and Jeggo, Penny (2015) SETDB1, HP1 and SUV39 promote repositioning of 53BP1 to extend resection during homologous recombination in G2 cells. Nucleic Acids Research, 43 (16). pp. 7931-7944. ISSN 0305-1048

Guo, Chaowan, Nakazawa, Yuka, Woodbine, Lisa, Björkman, Andrea, Shimada, Mayuko, Fawcett, Heather, Jia, Nan, Ohyama, Kaname, Li, Tao-Sheng, Nagayama, Yuji, Mitsutake, Norisato, Pan-Hammarström, Qiang, Gennery, Andrew R, Lehmann, Alan R, Jeggo, Penny A and Ogi, Tomoo (2015) XRCC4 deficiency in human subjects causes a marked neurological phenotype but no overt immunodeficiency. Journal of Allergy and Clinical Immunology, 136 (4). pp. 1007-1017. ISSN 0091-6749

Saha, Shreya, Woodbine, Lisa, Haines, Jacqueline, Coster, Margaret, Ricket, Nicole, Barazzuol, Lara, Ainsbury, Elizabeth, Sienkiewicz, Zenon and Jeggo, Penny (2014) Increased apoptosis and DNA double-strand breaks in the embryonic mouse brain in response to very low-dose X-rays but not 50 Hz magnetic fields. Journal of the Royal Society Interface, 11 (100). p. 20140783. ISSN 1742-5689

Kakarougkas, Andreas, Ismail, Amani, Chambers, Anna, Riballo, Queti, Herbert, Alex, Kunzel, Julia, Lobrich, Markus, Jeggo, Penny and Downs, Jessica (2014) Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin. Molecular Cell, 55 (5). pp. 723-732. ISSN 1097-2765

Woodbine, Lisa, Gennery, Andrew R and Jeggo, Penny A (2014) Reprint of “The clinical impact of deficiency in DNA non-homologousend-joining”. DNA Repair, 17. pp. 9-20. ISSN 1568-7864

Kakarougkas, A and Jeggo, P A (2014) DNA DSB repair pathway choice: an orchestrated handover mechanism. British Journal of Radiology, 87 (1035). p. 20130685. ISSN 0007-1285

Shibata, Atsushi, Moiani, Davide, Arvai, Andrew S, Perry, Jefferson, Harding, Shane M, Genois, Marie-Michelle, Maity, Ranjan, van Rossum-Fikkert, Sari, Kertokalio, Aryandi, Romoli, Filipo, Ismail, Amani, Ismalaj, Ermal, Petricci, Elena, Neale, Matthew J, Bristow, Robert G, Masson, Jean-Yves, Wyman, Claire, Jeggo, Penny and Tainer, John A (2014) DNA double-strand break repair pathway shoice is directed by distinct MRE11 nuclease activities. Molecular Cell, 53 (1). pp. 7-18. ISSN 1097-2765

Barton, Olivia, Naumann, Steffen C, Diemer-Biehs, Ronja, Kunzel, Julia, Steinlage, Monika, Conrad, Sandro, Makharashvili, Nodar, Wang, Jiadong, Feng, Lin, Lopez, Bernard S, Paull, Tanya T, Chen, Junji, Jeggo, Penny A and Löbrich, Markus (2014) Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1. Journal of Cell Biology, 206 (7). pp. 877-894. ISSN 0021-9525

Shibata, Atsushi, Moiani, Davide, Arvai, Andrew S, Perry, Jefferson, Harding, Shane M, Genoise, Marie-Michelle, Maity, Ranjan, van Rossum-Fikkert, Sari, Kertokalio, Aryandi, Romoli, Filippo, Ismail, Amani, Ismalaj, Ermal, Neale, Matthew J, Bristow, Robert G, Masson, Jean-Yves, Wyman, Claire, Jeggo, Penny A, Tainer, John A and Petricci, Elena (2013) DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Molecular Cell, 53 (1). pp. 7-18. ISSN 1097-2765

Lee, Pamela P, Woodbine, Lisa, Gilmour, Kimberly C, Bibi, Shahnaz, Cale, Catherine M, Amrolia, Persios J, Veys, Paul A, Davies, E Graham, Jeggo, Penny A and Jones, Alison (2013) The many faces of Artemis-deficient combined immunodeficiency — two patients with DCLRE1C mutations and a systematic literature review of genotype–phenotype correlation. Clinical Immunology, 149 (3B). pp. 464-474. ISSN 1521-6616

Woodbine, Lisa, Neal, Jessica A, Sasi, Nanda-Kumar, Shimada, Mayuko, Deem, Karen, Coleman, Helen, Dobyns, William B, Ogi, Tomoo, Meek, Katheryn, Davies, E Graham and Jeggo, Penny A (2013) PRKDC mutations in a SCID patient with profound neurological abnormalities. Journal of Clinical Investigation, 123 (7). pp. 2969-2980. ISSN 0021-9738

Stiff, Tom, Alagoz, Meryem, Alcantara, Diana, Outwin, Emily, Brunner, Han G, Bongers, Ernie M H F, O'Driscoll, Mark and Jeggo, Penny A (2013) Deficiency in origin licensing proteins impairs cilia formation: implications for the aetiology of meier-gorlin syndrome. PLoS genetics, 9 (3). e1003360. ISSN 1553-7404

Kakarougkas, Andreas, Ismail, Amani, Katsuki, Yoko, Freire, Raimundo, Shibata, Atsushi and Jeggo, Penny A (2013) Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 to resection. Nucleic Acids Research, 41 (22). pp. 10298-10311. ISSN 0305-1048

Kakarougkas, Andreas, Ismail, Amani, Klement, Karolin, Goodarzi, Aaron A, Conrad, Sandro, Freire, Raimundo, Shibata, Atsushi, Lobrich, Markus and Jeggo, Penny A (2013) Opposing roles for 53BP1 during homologous recombination. Nucleic Acids Research, 41 (21). pp. 9719-9731. ISSN 0305-1048

Pernot, Eileen, Hall, Janet, Baatout, Sarah, Benotmane, Mohammed Abderrafi, Blanchardon, Eric, Bouffler, Simon, El Saghire, Houssein, Gomolka, Maria, Guertler, Anne, Harms-Ringdahl, Mats, Jeggo, Penny and et al., (2012) Ionizing radiation biomarkers for potential use in epidemiological studies. Mutation Research/Reviews in Mutation Research, 751 (2). pp. 258-286. ISSN 1383-5742

Murray, Johanne M, Stiff, Tom and Jeggo, Penny A (2012) DNA double-strand break repair within heterochromatic regions. Biochemical Society Transactions, 40 (1). pp. 173-178. ISSN 0300-5127

Ogi, Tomoo, Walker, Sarah, Stiff, Tom, Hobson, Emma, Limsirichaikul, Siripan, Carpenter, Gillian, Prescott, Katrina, Suri, Mohnish, Byrd, Philip J, Matsuse, Michiko, Mitsutake, Norisato, Nakazawa, Yuka, Vasudevan, Pradeep, Barrow, Margaret, Stewart, Grant S, Taylor, A Malcolm R, O'Driscoll, Mark and Jeggo, Penny A (2012) Identification of the first ATRIP-deficient patient and novel mutations in ATR define a clinical spectrum for ATR-ATRIP Seckel Syndrome. PLoS Genetics, 8 (11). e1002945. ISSN 1553-7390

Goodarzi, Aaron A, Kurka, Thomas and Jeggo, Penelope A (2011) KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response. Nature Structural and Molecular Biology, 18 (7). pp. 831-839. ISSN 1545-9993

Bicknell, Louise S, Walker, Sarah, Klingseisen, Anna, Stiff, Tom, Leitch, Andrea, Kerzendorfer, Claudia, Martin, Carol-Anne, Yeyati, Patricia, Al Sanna, Nouriya, Bober, Michael, Johnson, Diana, Wise, Carol, Jackson, Andrew P, O'Driscoll, Mark and Jeggo, Penny A (2011) Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome. Nature Genetics, 43 (4). pp. 350-355. ISSN 1061-4036

Shibata, A, Conrad, S, Birraux, J, Geuting, V, Barton, O, Ismail, A, Kakarougkas, A, Meek, K, Taucher-Scholz, G, Lobrich, M and Jeggo, P (2011) Factors determining DNA double-strand break repair pathway choice in G2 phase. EMBO Journal, 30 (6). pp. 1079-1092. ISSN 0261-4189

Jeggo, Penny (2010) The role of the DNA damage response mechanisms after low-dose radiation exposure and a consideration of potentially sensitive individuals. Radiation Research, 174 (6b). pp. 825-832. ISSN 0033-7587

Deckbar, Dorothee, Stiff, Thomas, Kock, Barbara, Reis, Caroline, Löbrich, Markus and Jeggo, Penny (2010) The limitations of the G1-S checkpoint. Cancer Research, 70 (11). pp. 4412-4421. ISSN 0008-5472

Lobrich, Markus, Shibata, Atsushi, Beucher, Andrea, Fisher, Anna, Esminger, Michael, Goodarzi, Aaron A, Barton, Olivia and Jeggo, Penny A (2010) γH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization. Cell Cycle, 9 (4). pp. 662-669. ISSN 1538-4101

Noon, Angela T, Shibata, Atsushi, Rief, Nicole, Lobrich, Markus, Stewart, Grant S, Jeggo, Penelope A and Goodarzi, Aaaron A (2010) 53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair. Nature Cell Biology, 12 (2). pp. 177-184. ISSN 1465-7392

Jeggo, Penny and Lavin, Martin F (2009) Cellular Radiosensitivity: How much better do we understand it? International Journal of Radiation Biology, 85 (12). pp. 1061-1081. ISSN 0955-3002

Jeggo, Peggy A. (2009) Risks from low dose/dose rate radiation: what an understanding of DNA damage response mechanisms can tell us. Health Physics, 97 (5). pp. 416-425. ISSN 0017-9078

Covo, Shay, de Villartay, Jean-Pierre, Jeggo, Penny A and Livneh, Zvi (2009) Translesion DNA synthesis-assisted non-homologous end-joining of complex double-strand breaks prevents loss of DNA sequences in mammalian cells. Nucleic Acids Research, 37 (20). pp. 6737-6745. ISSN 0305-1048

Nijnik, Anastasia, Dawson, Sara, Woodbine, Lisa, Visetnoi, Supawan, Bennett, Sophia, Jones, Margaret, Turner, Gareth D, Jeggo, Penelope A, Goodnow, Christopher C and Cornall, Richard J (2009) Impaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome. Journal of Clinical Investigation, 119 (6). pp. 1696-1705. ISSN 00219738

Goodarzi, Aaron A, Noon, Angela T and Jeggo, Penny A (2009) The impact of heterochromatin on DSB repair. Biochemical Society Transactions, 37 (3). pp. 569-576. ISSN 03005127

Goodarzi, Aaron A, Noon, Angela T and Jeggo, Penny A (2009) The impact of heterochromatin on DSB repair. Biochemical Society Transactions, 37 (3). pp. 569-576. ISSN 0300-5127

Riballo, Enriqueta, Woodbine, Lisa, Stiff, Thomas, Walker, Sarah A., Goodarzi, Aaron A. and Jeggo, Penny A. (2009) XLF-Cernunnos promotes DNA ligase IV-XRCC4 re-adenylation following ligation. Nucleic Acids Research, 37 (2). pp. 482-492. ISSN 0305-1048

Griffith, Elen, Walker, Sarah, Martin, Carol-Anne, Vagnarelli, Paola, Stiff, Tom, Vernay, Bertrand, Al Sanna, Nouriya, Saggar, Anand, Hamel, Ben, Earnshaw, William C, Jeggo, Penny A, Jackson, Andrew P and O'Driscoll, Mark (2008) Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling. Nature Genetics, 40 (2). pp. 232-235. ISSN 1061-4036

Griffith, E, Walker, Sarah, Stiff, Thomas, Martin, C-A, Vagnarelli, P, Vernay, B, Sanna, N.A, Saggar, A, Hamel, B, Earnshaw, W.C, Jeggo, Penny, Jackson, A.P and O'Driscoll, Mark (2008) Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling. Nature Genetics, 40 (2). pp. 232-236. ISSN 10614036

O'Driscoll, Mark, Dobyns, William B, van Hagen, Johanna M and Jeggo, Penny A (2007) Cellular and clinical impact of Haploinsufficiency for genes involved in ATR signaling. American Journal of Human Genetics, 81 (1). pp. 77-86. ISSN 0002-9297

Nijnik, Anastasia, Woodbine, Lisa, Marchetti, Caterina, Dawson, Sara, Lambe, Teresa, Liu, Cong, Rodrigues, Neil P, Crockford, Tanya L, Cabuy, Erik, Vindigni, Alessandro, Enver, Tariq, Bell, John I, Slijepcevic, Predrag, Goodnow, Christopher C, Jeggo, Penny A and Cornall, Richard J (2007) DNA repair is limiting for haematopoietic stem cells during ageing. Nature, 447, 686-690. Nature, 447. pp. 686-690. ISSN 0028-0836

Stiff, Thomas, Walker, Sarah, Cerosaletti, Karen, Goodarzi, Aaron, Petermann, Mylene Pamela, Concannon, Pat, O'Driscoll, Mark and Jeggo, Penny (2006) ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling. EMBO Journal, 25 (24). pp. 5775-5782. ISSN 0261-4189

Jeggo, Penny and Löbrich, Markus (2006) Radiation induced DNA damage responses. Radiation Protection Dosimetry, 122 (1-4). pp. 124-127. ISSN 1742-3406

O'Driscoll, Mark and Jeggo, Penny (2006) The role of DSB repair-insights from human genetics. Nature Reviews Genetics, 7 (1). pp. 45-54. ISSN 1471-0056

Stiff, Thomas, Reis, Caroline, Alderton, Gemma K, Woodbine, Lisa, O'Driscoll, Mark and Jeggo, Penny A (2005) Nbs1 is required for ATR-dependent phosphorylation events. EMBO Journal, 24 (1). pp. 199-208. ISSN 0261-4189

Cabuy, E, Newton, C, Joksic, G, Woodbine, L, Koller, B, Jeggo, P A and Slijepcevic, P (2005) Accelerated telomere shortening and telomere abnormalities in radiosensitive cell lines. Radiation Research, 164 (1). pp. 53-62. ISSN 0033-7587

Gennery, A.R, Slatter, M.A., Bhattacharya, A, Barge, D, Haigh, S, O'Driscoll, Mark, Coleman, R, Abinun, M, Flood, T.J, Cant, A.J and Jeggo, Penny (2004) The clinical and biological overlap between Nijmegen Breakage syndrome and Fanconi Anemia. Clinical Immunology, 113 (2). pp. 214-219. ISSN 1521-6616

O'Driscoll, Mark, Gennery, AR, Seidel, J, Concammon, P and Jeggo, Penny (2004) An Overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome. DNA Repair, 3 (8-9). pp. 1227-1235. ISSN 15687864

Girard, Pierre-Marie, Kysela, Boris, Härer, Christine J, Doherty, Aidan J and Jeggo, Penny A (2004) Analysis of DNA ligase IV mutations found in LIG4 syndrome patients: the impact of two linked polymorphisms. Human Molecular Genetics, 13 (20). pp. 2369-2376. ISSN 0964-6906

Izsvák, Zsuzsanna, Stüwe, Eva E, Fiedler, Dora, Katzer, Andrea, Jeggo, Penny A and Ivics, Zoltán (2004) Healing the wounds inflicted by Sleeping Beauty transposition by double-strand break repair in mammalian somatic cells. Molecular Cell, 13(2). pp. 279-290. ISSN 1097-2765

Gennery, A R, Slatter, M A, Bhattacharya, A, Barge, D, Haigh, S, O'Driscoll, M, Coleman, R, Abinun, M, Flood, T J, Cant, A J and Jeggo, P A (2004) The clinical and biological overlap between nijmegen breakage syndrome and fanconi anaemia. Clinical Immunology, 113(2). pp. 214-219. ISSN 1521-6616

Smith, Julianne, Riballo, Enriqueta, Kysela, B, Baldeyron, Celine, Manolis, Kostas, Masson, Christel, Lieber, Michael R, Papadopoulo, Dora and Jeggo, Penny (2003) Impact of DNA ligase IV on the fidelity of end joining in human cells. Nucleic Acids Research, 31(8). pp. 2157-2167. ISSN 0305-1048

Dai, Y, Kysela, B, Hanakahi, L A, Manolis, K, Riballo, E, Stumm, M, Harville, T O, West, S C, Oettinger, M A and Jeggo, P A (2003) Non-homologous end joining and V(D)J recombination require an additional factor. Proceedings of the National Academy of Sciences, 100 (5). pp. 2462-2467. ISSN 1091-6490

Foray, Nicolas, Marot, Didier, Gabriel, Anastasia, Randrianarison, Voahangy, Carr, Antony M, Perricaudet, Michel, Ashworth, Alan and Jeggo, Penny (2003) A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein. EMBO Journal, 22 (11). pp. 2860-2871. ISSN 0261-4189

Hirao, Atsushi, Cheung, Alison, Duncan, Gordon, Girard, Pierre-Marie, Elia, Andrew J, Wakeham, Andrew, Okada, Hitoshi, Sarkissian, Talin, Wong, Jorge A, Sakai, Takashi, de Stanchina, Elisa, Bristow, Robert G, Suda, Toshio, Lowe, Scott W, Jeggo, Penny A, Elledge, Stephen J and Mak, Tak W (2002) Chk2 is a tumour suppressor that regulates apoptosis in both an ataxia telangiectasia mutad (ATM)-dependent and an ATM-independent manner. Molecular and Cellular Biology, 22(18). pp. 6521-6532. ISSN 0270-7306

Foray, Nicolas, Marot, Didier, Randrianarison, Voahangy, Venezia, Nicole Dalla, Picard, Didier, Perricaudet, Michel, Favaudon, Vincent and Jeggo, Penny (2002) Constitutive association of BRCA1 and c-Abl and its ATM-dependent disruption after irradiation. Molecular and Cellular Biology, 22(12). 4020-4032.. ISSN 0270-7306

O'Driscoll, Mark, Cerosaletti, Karen M, Girard, Pierre-M, Dai, Yan, Stumm, Markus, Kysela, Boris, Hirsch, Betsy, Gennery, Andrew, Palmer, Susan E, Seidel, Jörg, Gatti, Richard A, Varon, Raymonda, Oettinger, Marjorie A, Neitzel, Heidemarie, Jeggo, Penny A and Concannon, Patrick (2001) DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency. Molecular Cell, 8 (6). pp. 1175-1185. ISSN 1097-2765

O'Driscoll, Mark, Cerosaletti, Karen M, Girard, Pierre-M, Dai, Yan, Stumm, Markus, Kysela, Boris, Hirsch, Betsy, Gennery, Andrew, Palmer, Susan E, Seidel, Jörg, Gatti, Richard A, Varon, Raymonda, Oettinger, Marjorie A, Neitzel, Heidemarie, Jeggo, Penny A and Concannon, Patrick (2001) DNA Ligase IV mutations identified in patients exhibiting development delay and immunodeficiency. Molecular Cell, 8. pp. 1175-1185.

Girard, P M, Foray, N, Stumm, M, Waugh, A, Riballo, E, Maser, R S, Phillips, W P, Petrini, J, Arlett, C F and Jeggo, P A (2000) Radiosensitivity in Nijmegen Breakage Syndrome cells is attributable to a repair defect and not cell cycle checkpoint defects. Cancer Research, 60. 4881 - 4888. ISSN 0008-5472

Riballo, E, Critchlow, S E, Teo, S-H, Doherty, A J, Priestley, A, Broughton, B, Kysela, B, Beamish, H, Plowman, N, Arlett, C F, Lehmann, A R, Jackson, S P and Jeggo, P A (1999) Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient. Current Biology, 9 (13). 699 - 702. ISSN 0960-9822

Conference or Workshop Item

Jeggo, Penny (2009) Mechanisms conferring sensitivity to low dose radiation exposure and consideration of potentially sensitivie individuals. In: Late health effects of ionizing radiation: bridging the experimental and epidemiological divide, 4-6 May 2009, Georgetown University, Washington D.C..